Role of Stromal Myofibroblasts Infiltrating Colon Cancer in Tumor Invasion

Myofibroblastic stromal reaction and expression of tenascin-C and laminin in prostate adenocarcinoma

“…Myofibroblasts produced lytic enzymes able to degrade the BM surrounding tumour glands, and also participated in the synthesis of the ECM components of the tumour stroma, which subsequently altered the adhesive and migratory properties of the epithelial colon cancer cells. 16 In prostate cancer reactive stroma is mainly composed of myofibroblast and fibroblast what has been clearly shown in some previous investigation. 2,3 Our current study confirmed appearance of myofibroblasts in prostate cancer reactive stroma, especially in Gleason pattern 3 tumours, but not in adjacent peritumourous tissue and stroma in BPH.…”

“…15 Newest concepts which point out the importance of tumourous stroma in tumour development and progression intensified investigation of stroma in many tumours, including prostate adenocarcinoma. 2,3,[16][17][18][19][20] Reactive stroma in breast and colon carcinoma has been described and in these cancers reactive stroma is composed of mixture of myofibroblasts, fibroblasts, endothelial cells and immune cells. Although all of these cells could be potentially involved in cancerogenesis, myofibroblasts were of special interest.…”

“…Although all of these cells could be potentially involved in cancerogenesis, myofibroblasts were of special interest. [16][17][18] Using a coimplantation tumour xenograft model, Orimo et al 18 demonstrated that carcinoma-associated fibroblasts (CAFs) extracted from human breast carcinomas promoted the growth of admixed breast carcinoma cells significantly more than do normal mammary fibroblasts derived from the same patients. The CAFs, which exhibited the traits of myofibroblasts, played a central role in promoting the growth of tumour cells through their ability to secrete stromal cell-derived factor 1 (SDF-1), which stimulated tumour growth directly, acting through the cognate receptor, CXCR4 that is expressed by carcinoma cells.…”

“…The CAFs also promoted angiogenesis by recruiting endothelial progenitor cells into carcinomas. 18 Martin et al 16 showed that myofibroblasts were accumulated at the invasive front of the colorectal carcinomas. Myofibroblasts produced lytic enzymes able to degrade the BM surrounding tumour glands, and also participated in the synthesis of the ECM components of the tumour stroma, which subsequently altered the adhesive and migratory properties of the epithelial colon cancer cells.…”

Tumour-derived TGF-β1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells

“…Accumulation of fibroblast-like cells, including myofibroblasts, is frequently observed associated with the edge of an actively expanding tumour mass (Martin et al, 1996;Emura et al, 2000). Such a phenomenon has been demonstrated, to different extents, in a variety of tumours and there is increasing evidence that tumour stroma may promote tumour progression (Liotta and Kohn, 2001;Pupa et al, 2002).…”