Role of stressful life events in induction or exacerbation of psoriasis and chronic urticaria

Malhotra, Sheetal; Mehta, Vivek

doi:10.4103/0378-6323.45100

Cited by 89 publications

(73 citation statements)

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“…There are reports showing stressful life events, such as loss of close family member, financial problems, major personal illness preceded onset or exacerbation of the disease in a considerable subset of patients with chronic spontaneous urticaria [10,11]. Although many patients report stress to exacerbate their disease, there is a lack of well-controlled studies on this subject [3].…”

Section: Introductionmentioning

confidence: 99%

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Urticaria and Angioedema

Engın¹,

Oba²,

Serdaroğlu³

2017

A Comprehensive Review of Urticaria and Angioedema

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Urticaria is a common mast cell-mediated dermatosis presenting with pruritic erythematous superficial plaques also known as hives or wheals. Angioedema is an acute condition manifesting as localized edema affecting the skin and mucous membranes. In contrast with urticaria, itching is often absent, the skin appears normal and the edema occurs in deeper dermal and subcutaneous tissues in angioedema. Spontaneous urticaria can either be acute lasting less than 6 weeks or chronic with a duration of more than 6 weeks. In acute urticaria cases, an underlying cause, mostly medications, foods and infections, may be found in approximately 50% of patients. However, spontaneous urticaria is generally idiopathic. First-line treatment option for both acute and chronic urticaria is non-sedating H 1 antihistamines. Patients with recalcitrant disease are candidates for therapy with corticosteroids, immunosuppressives or omalizumab treatment. There are two different mechanisms causing angioedema. The first is mast cell mediated and is considered to be part of the spectrum of spontaneous or inducible urticarias. Patients present with angioedema alone or angioedema combined with urticaria. The second is bradykinin-induced angioedema, as observed in the hereditary angioedema and angiotensin-converting enzyme (ACE) inhibitor-induced angioedema.

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Section: Introductionmentioning

confidence: 99%

“…Symptomatic relief with suppression of the pruritus and reduction of the number and size of wheals is the main goal of treatment. Loratadine and cetirizine can be used starting from 6 months of age and are also safe during pregnancy [9,10]. Efficacy of antihistamines is often patient specific and none are consistently superior [16].…”

Section: Antihistaminesmentioning

confidence: 99%

Urticaria and Angioedema

Engın¹,

Oba²,

Serdaroğlu³

2017

A Comprehensive Review of Urticaria and Angioedema

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“…12 Stress triggers the symptoms and affects the severity of symptoms in patients with both FM and CU. 13,14 Some pathological changes have been described in the skin biopsies of patients with FM as resembling the cellular and cytokine involvement in the biopsy specimens of patients with CU. [15][16][17][18][19] In addition, it has been suggested that there is an autonomic dysfunction in patients with FM and CU, and sympathomimetic amines may lead to improvement in the symptoms of the two diseases when there is a resistance to conventional therapies.…”

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confidence: 99%

Is There An Association Between Chronic Urticaria and Fibromyalgia Syndrome?

et al. 2014

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Objectives: Chronic urticaria (CU) and fibromyalgia (FM) are different types of diseases with unclear etiopathogeneses but share many clinical and histochemical features. This study aims to make a recognization on these features and examines whether patients with CU are also affected by FM. Patients and methods:Forty patients with CU and 38 healthy controls were enrolled to this study. All of the participants were assessed according to the 1990 American College of Rheumatology (ACR) classification criteria for FM and asked questions regarding the clinical features of FM. The quality of life was assessed by the Nottingham Health Profile (NHP), while the psychological status was evaluated using the Hospital Anxiety and Depression Scale (HADS). Results:The incidence of FM was higher among the patients with CU (32.5%) than the controls (10.5%) (p=0.019). We indicated that the patients with CU suffered restrictions regarding to quality of life as assessed by the NHP. NHP-sleep (p=0.035), NHP-social isolation (p=0.032) and NHP-emotional reaction (p=0.027) scores were significantly higher compared to HCs. The HADS-depression scores were also significantly higher in the patients with CU (p=0.006). The patients with CU and concomitant FM had higher total NHP scores than those without FM (p<0.001). Conclusion:Clinicians must be alerted to the possible coexistence of FM in CU patients. Patients with CU have higher rates of FM than the general population and this results in more restrictions in daily life in these patients than those with CU alone. Therefore, additional treatment protocols may be required to be implicated for the treatment of patients with both CU and FM.

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“…Knowledge of this phenomenon may be useful for professionals who would like to explore psychosocial stressors of chronic skin patients. This is relevant in dermatological care beacuse psychological stress plays an important role in in triggering or exacerbating chronic skin diseases (49). How can attachment styles and attitudes affect patients' consultations with a dermatologist?…”

Section: Discussionmentioning

confidence: 99%

“…Skin diseases can affect patients in their health psychological functioning, e.g. the condition of our skin has an effect on our body image, self-esteem and the way others perceive us (48) Psychological stress plays an important role in in triggering or exacerbating chronic skin diseases (49). In a study arranged by Pärna et al (50) sleep disorder symptoms were the most important form of distress among patients with chronic skin conditions.…”

Section: Psychodermatologymentioning

confidence: 99%

Adherence and psychological attributes in dermatology

Szabó

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Role of stressful life events in induction or exacerbation of psoriasis and chronic urticaria

Cited by 89 publications

References 0 publications

Urticaria and Angioedema

Urticaria and Angioedema

Is There An Association Between Chronic Urticaria and Fibromyalgia Syndrome?

Adherence and psychological attributes in dermatology

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