Role of Steroid Therapy after Ischemic Stroke by n-Methyl-d-Aspartate Receptor Gene Regulation

Tameh, Abolfazl Azami; Karimian, Mohammad; Zare-Dehghanani, Zahra; Aftabi, Younes; Beyer, Cordian

doi:10.1016/j.jstrokecerebrovasdis.2018.06.041

Cited by 28 publications

(12 citation statements)

References 39 publications

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“…Additionally, in the rat brain frontal cortex, progesterone treatment increases the number of viable mitochondria (Andrabi et al, ). These positive results are in line with recently published data showing a direct interaction between progesterone and NMDA receptor subunits (Tameh et al, ). In rats suffering from middle cerebral artery occlusion, neurosteroid treatment resulted in an upregulation of NMDA receptor subunit 2A in the cortical penumbra region, which is associated with prosurvival effects (Wu and Tymianski, ).…”

Section: Progesterone and Prssupporting

confidence: 93%

“…In this context, the fact that progesterone is also expressed in the male organism is often neglected (Schumacher et al, ). Besides this, progesterone has been shown to promote neuroprotection after neonatal hypoxic brain injury, ischemic stroke, and TBI in animal models (Allitt et al, ; Dong et al, ; Tameh et al, ). Especially, the activation of progesterone receptor (PR) during treatment of the traumatic brain and ischemic stroke appeared to be particularly effective (Wnuk and Kajta, ).…”

Section: Progesterone and Prsmentioning

confidence: 99%

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Progesterone Effects in the Nervous System

Theis

Theiß

2019

The Anatomical Record

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The sex hormone progesterone is mainly known as a key factor in establishing and maintaining pregnancy. In addition, progesterone has been shown to induce morphological changes in the central and peripheral nervous system by increasing dendrito-, spino-, and synaptogenesis in Purkinje cells (Wessel et al.: Cell Mol Life Sci (2014a) 1723-1740 and increasing axonal outgrowth in dorsal root ganglia (Olbrich et al.: Endocrinology (2013) 3784-3795). These effects mediated mainly by the classical progesterone receptors (PRs) A and B seem to be limited to young neurons. It may be assumed that microRNAs (miRNAs), which are potent regulators of nervous system maturation and degeneration, are also involved in the regulation of progesterone-mediated neuronal plasticity by altering the expression patterns of the corresponding PR A/B receptors (Theis and Theiss: Neural Regen Res (2015) 547-549, Pieczora et al.: Cerebellum (2017) 376-387). This review critically discusses current data on the neuroprotective effect of progesterone and its corresponding receptors in the nervous system, with possible regulatory processes by miRNAs. Preclinical studies on stroke and traumatic brain injury revealed neuroprotective and neuroregenerative effects of progesterone in the treatment of severe neurological diseases in animal models, but have so far failed in humans. In this context, the identification of specific miRNAs that regulate the expression of progesterone and PR could help to exploit the neuroprotective potential of progesterone for the treatment of various neurological disorders. The human nervous system is a highly complex tissue composed of neurons and glial cells with a limited ability to regenerate after lesion or degeneration. In particular, the loss of neurons, for example, due to aging processes, stroke, or traumatic brain injury (TBI), is mostly irreversible. The function of the degenerating neurons can be partially compensated by neighboring neurons, but astroglial-fibrotic scar formation minimizes neuronal regeneration .Progesterone, a sexual hormone, is mainly known for its key role in the female reproductive circuit and the maintenance of pregnancy. In this context, the fact that progesterone is also expressed in the male organism is often neglected (Schumacher et al., 2014). Besides this, Abbreviations: BBB = blood brain barrier; CNS = central nervous system; DRG = dorsal root ganglia; GABA = Gamma-amino butyric acid; miRNA = microRNA; NMDAR = N-Methyl-D-aspartate receptor; PC = Purkinje cells; PGRMC1 = progesterone receptor membrane component 1; PNS = peripheral nervous system; PR = progesterone receptor; SCI = spinal cord injury; TBI = traumatic brain injury

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Section: Progesterone and Prssupporting

confidence: 93%

Section: Progesterone and Prsmentioning

confidence: 99%

Progesterone Effects in the Nervous System

Theis

Theiß

2019

The Anatomical Record

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“…Evaluation of these effects by in vitro and in vivo methods is very time and cost consuming (Zamani-Badi et al, 2018;Bafrani et al, 2019). Assessment of the mentioned impacts and other molecular assessments by in silico tools may be too beneficial (Noureddini et al, 2018;Tameh et al, 2018). A study with bioinformatics analysis revealed that both C677T and A1298C genetic variations made significant changes in the secondary structure of MTHFR-mRNA.…”

Section: Discussionmentioning

confidence: 99%

Association Analysis of Methylenetetrahydrofolate Reductase Common Gene Polymorphisms with Breast Cancer Risk in an Iranian Population: A Case-Control Study and a Stratified Analysis

Karimian

Rezazadeh

Khamehchian

2020

Asian Pac J Cancer Prev

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breast diseases, history of breast cancer in the first-degree family, early menstruation, late menopause, nulliparity, and higher socioeconomic status (Kamińska et al., 2015). Genetic factors also play an important role in tumor formation and progression. For example, aneusomy of chromosome 17, deletion of loci at 16q, 11q, 6q, and 3p and polymorphisms in genes involved in the key cellular pathways can be the main risk factors for breast cancer (Newsham, 1998). One of the important cellular pathways is the folate metabolism cycle which includes many genes such as methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR). The role of the MTHFR enzyme is to convert 5,10-methylenetetrahydrofolate (5,10-MTHF) to

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“…But, the missense mutations could alter the structure and function of proteins (Noureddini et al, 2018;Bafrani et al, 2019) what may be true for GSTP1-Ile105Val genetic variation. Evaluation of the impacts of genetic variations by biological experiments is a very difficult process and evaluation of these impacts could be much easier with the in silico tools (Tameh et al, 2018;Zamani-Badi et al, 2018). In this study, also we employed the SNPeffects bioinformatics tool to evaluate the molecular effects of Ile105Val SNP on the GSTP1 gene and we found that this polymorphism decreases the amyloid propensity of GSTP1 protein and therefore, the pathogenic effect of Ile105Val may arise from this issue.…”

Section: Discussionmentioning

confidence: 91%