Role of Stem Cells in Augmenting Dental Implant Osseointegration: A Systematic Review

Sayed, Mohammed E.; Mugri, Maryam H.; Almasri, Mazen; Al-Ahmari, Manea Musa; Bhandi, Shilpa; Madapusi, Thodur Balaji; Varadarajan, Saranya; Raj, A. Thirumal; Reda, Rodolfo; Testarelli, Luca; Patil, Shankargouda

doi:10.3390/coatings11091035

Cited by 14 publications

(10 citation statements)

References 45 publications

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“…20 This phenomenon can be correlated with the relationship between LLLT stimulation and the tissue stem cells reacting to it, inducing the new formation and healing of the peri-implant soft tissues and the periimplant bone. 32 Similar results were found in the studies by Torkzaban et al 22 and Bittencourt Lobato et al, 24 even though the observed differences were not statistically significant. The pooled result of all the studies included in the meta-analysis showed a positive effect of the PBM therapy on dental implant stability in contrast to the other systematic review results.…”

Section: Discussionsupporting

confidence: 82%

Effectiveness of the photobiomodulation therapy using low-level laser around dental implants: A systematic review and meta-analysis

Vande¹,

Sanyal²,

Nilesh³

2022

Dent. Med. Probl.

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Background. The photobiomodulation (PBM) therapy has been applied in various fields. Its use in implant dentistry has been proven through various animal, in vitro, and recently also clinical studies. However, the cumulative data of its effect around dental implants in patients is limited.Objectives. The purpose of the present study was to evaluate whether or not the PBM therapy has a positive effect around dental implants and on implant stability. Material and methods.The studies included in the review and meta-analysis were selected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the PICOS criteria. The RoB 2 tool was used for assessing the risk of bias and the RevMan software, v. 5.0, was used for meta-analysis. Quantitative analysis was done considering the implant stability measurement as the outcome. The mean and standard deviation (M ±SD) values for implant stability as well as the sample size were extracted from the articles, and the inverse variance method with random effects was used for meta-analysis. The forest plots for all time intervals were inspected to estimate the heterogeneity by assessing the I 2 statistic.Results. A total of 148 articles were initially retrieved, out of which 81 remained after duplicate removal. Ten articles were included in the review after rejecting 68 on the basis of title and abstract. Seven were eligible for quantitative analysis. The meta-analysis showed non-significant differences in primary stability in control and laser groups at baseline (p = 0.63) and 3 months and above (p = 0.06). At 2 weeks, 1 month and 2 months, the results were statistically significant with p = 0.01, p = 0.02 and p = 0.04, respectively.Conclusions. The PBM therapy showed a positive effect on implant stability during the early stages of healing and can be considered for patients with dental implants.

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Section: Discussionsupporting

confidence: 82%

Effectiveness of the photobiomodulation therapy using low-level laser around dental implants: A systematic review and meta-analysis

Vande¹,

Sanyal²,

Nilesh³

2022

Dent. Med. Probl.

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“…Dental implants are commonly used in dentistry, orthopedic surgery and other specialties that work on human skeleton ( Sayed et al, 2021 ). Biocompatibility properties of these materials have been studied extensively.…”

Section: Introductionmentioning

confidence: 99%

Titanium dioxide dental implants surfaces related oxidative stress in bone remodeling: a systematic review

Abdulhameed

Al‐Rawi

Omar

et al. 2022

PeerJ

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Background Titanium dioxide dental implants have a controversial effect on reactive oxygen species (ROS) production. ROS is necessary for cellular signal transmission and proper metabolism, but also has the ability to cause cell death as well as DNA, RNA, and proteins damage by excessive oxidative stress. This study aimed to systematically review the effect of titanium dioxide dental implant-induced oxidative stress and its role on the osteogenesis-angiogenesis coupling in bone remodeling. Methods This systematic review was performed conforming to preferred reporting items for systematic review and meta-analysis (PRISMA) model. Four different databases (PubMed, Science Direct, Scopus and Medline databases) as well as manual searching were adopted. Relevant studies from January 2000 till September 2021 were retrieved. Critical Appraisal Skills Programme (CASP) was used to assess the quality of the selected studies. Results Out of 755 articles, only 14 which met the eligibility criteria were included. Six studies found that titanium dioxide nanotube (TNT) reduced oxidative stress and promoted osteoblastic activity through its effect on Wnt, mitogen-activated protein kinase (MAPK) and forkhead box protein O1 (FoxO1) signaling pathways. On the other hand, three studies confirmed that titanium dioxide nanoparticles (TiO2NPs) induce oxidative stress, reduce ostegenesis and impair antioxidant defense system as a significant negative correlation was found between decreased SIR3 protein level and increased superoxide (O2•-). Moreover, five studies proved that titanium implant alloy enhances the generation of ROS and induces cytotoxicity of osteoblast cells via its effect on NOX pathway. Conclusion TiO2NPs stimulate a wide array of oxidative stress related pathways. Scientific evidence are in favor to support the use of TiO2 nanotube-coated titanium implants to reduce oxidative stress and promote osteogenesis in bone remodeling. To validate the cellular and molecular cross talk in bone remodeling of the present review, well-controlled clinical trials with a large sample size are required.

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“…Recently, modern techniques of stem cell stimulation and bone neo-apposition with grafts are progressing; they also offer good opportunities in implant re-osseointegration. [ 8 ] To improve the stability and osseointegrations of implants, the dentistry industry uses a variety of scaffolds and growth factors [ 8 , 9 ]. Bioactive-molecule-loaded scaffolds show a main role in the promotion of stability and osseointegration in implants [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…[ 8 ] To improve the stability and osseointegrations of implants, the dentistry industry uses a variety of scaffolds and growth factors [ 8 , 9 ]. Bioactive-molecule-loaded scaffolds show a main role in the promotion of stability and osseointegration in implants [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Effects of Curcumin Nanocrystals against Porphyromonas gingivalis Isolated from Patients with Implant Failure

Dizaj

Shokrgozar

Yazdani

et al. 2022

Clinics and Practice

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Background. Despite their benefits, dental implants may sometimes fail for a diversity of causes; the most common reasons of failure are infection and bone loss. Porphyromonas gingivalis (P. gingivalis) bacteria show a major role in peri-implantitis infection and dental implant failure. Methods. In this study, the prevalence of P. gingivalis isolated from the gingival crevicular fluid (GCF) of fifteen Iranian patients with implant failure (more than 1/3 of the implant length), who had average oral and dental hygiene and no antibiotic use for at least one month, was determined. Moreover, the antimicrobial effects of curcumin nanocrystals against isolated P. gingivalis were investigated. The collected samples from patients were transferred to a microbiology laboratory to culture. The presence of P. gingivalis in the culture media was confirmed using a trypsin reagent test. An isolate from a patient with the highest colony count was selected to evaluate the antibacterial effects of curcumin nanoparticles. The inhibition zone diameter, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) were determined. Results. Out of fifteen patients, eight (53.33%) were positive for the presence of P. gingivalis. The results of the microbial tests showed that curcumin nanoparticles had an MIC of 6.25 µg/mL and an MBC of 12.5 µg/mL. Conclusions. The use of curcumin nanoparticles may control the bacterial infection around the implant.

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Role of Stem Cells in Augmenting Dental Implant Osseointegration: A Systematic Review

Cited by 14 publications

References 45 publications

Effectiveness of the photobiomodulation therapy using low-level laser around dental implants: A systematic review and meta-analysis

Effectiveness of the photobiomodulation therapy using low-level laser around dental implants: A systematic review and meta-analysis

Titanium dioxide dental implants surfaces related oxidative stress in bone remodeling: a systematic review

Antibacterial Effects of Curcumin Nanocrystals against Porphyromonas gingivalis Isolated from Patients with Implant Failure

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