Role of statins for neuroprotection

Exploring effects of Simvastatin on coagulation mediators to alleviate the advancement of high cholesterol diet triggered neurodegeneration

“…[22] A number of preclinical and early phase trials support potential neuroprotective effect of statins after acute neurological injury and intracerebral hemorrhage (ICH). [23,24] Still there exists a large void in understanding the mechanisms of statininduced neuroprotection. [25,26] Since, there is no existing therapy for obesity linked neurodegeneration, and also because both of these disorders are associated with hypercoagulation, we sought to elucidate the effects of Simvastatin on coagulation mediators and on neuropathology associated with obesity.…”