Role of STAT6 and SMAD2 in a model of chronic allergen exposure: a mouse strain comparison study

Abstract

The activation of signalling pathways and nuclear translocation of signalling molecules downstream of IL-13 and TGF-beta1 further support the central role of these molecules in the pathology and dysfunction in animal models of asthma. Activation of signalling pathways downstream from IL-13 and TGF-beta1 may be more relevant in disease progression than elevations in airway inflammation alone.

Effects of furosemide on allergic asthmatic responses in mice

“…As described previously [17], BAL cells were classified, based on morphologic criteria, as macrophages, neutrophils, lymphocytes or eosinophils.…”

An Essential Regulatory Role of Downstream of Kinase-1 in the Ovalbumin-Induced Murine Model of Asthma

“…One of the major transcription factors regulating the expression of Th2 cytokine is STAT6 [10], [11], [12]. The STATs have been shown to be important in the regulation of cytokines and growth factor-inducible transcription factors in immune response [13], [14].…”

From Mouse to Man: Translational Value of Animal Models of Allergic Rhinitis

“…Like asthma, AR is a chronic disease marked by episodic rounds of inflammation, yet few rodent AR models have been designed to examine long-term alterations and potential airway remodeling of the nasal mucosa. This limitation might easily have been filled, in part, by examining the nose from mice used in a number of well-designed, chronic experimental asthma models (Hirota et al 2009;Ikeda et al 2003;McMillan and Lloyd 2004;Yu et al 2006). Repeated challenge with allergen for weeks or months produces many features of human asthma, including subepithelial fibrosis, smooth muscle and mucus cell hyperplasia, and epithelial exfoliation.…”