Role of soy isoflavone in preventing aging changes in rat testis: Biochemical and histological studies

Al-Shaikh, Turki M.

doi:10.1016/j.sjbs.2022.103423

Cited by 9 publications

(4 citation statements)

References 24 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, concomitant with our histological findings, we found a significant decrease in gene expression levels of the cell proliferation marker Ki-67 in aged control relative to adult control rats. This finding was in agreement with other researches (26,34,35) that demonstrated a significant decrease in epithelial proliferation and rate of tissue turnover with age. Our results also revealed that aged rats treated with licorice showed significant increase in Ki-67 expression compared to those untreated.…”

Section: Discussionsupporting

confidence: 94%

The potential protective effect of licorice against age-related changes in the circumvallate papillae of albino rats

Farag,

El Moshy

2023

Egyptian Dental Journal

View full text Add to dashboard Cite

Licorice extract has been used effectively to treat various diseases, but research on its anti-aging potential, particularly in the gustatory lingual papilla, is limited. Consequently, this study aimed to assess the potential of licorice extract to ameliorate age-related changes in the circumvallate taste papilla of rats. Thirty adult male Albino rats (6 months old) were randomly divided into three groups; Group I (adult control group) was sacrificed immediately, while Group II (aged control group) and Group III (aged licorice-treated group) were sacrificed at the age of 12 months. The circumvallate papillae in each experimental group from the tongue were analyzed histologically and histomorphometrically. The expressions of Ki-67 and neural cell adhesion molecule (NCAM) were examined using reverse transcriptase polymerase chain reaction. The superoxide dismutase levels (SOD) were determined using a colorimetric SOD activity assay. The circumvallate papillae of group II revealed various structural alterations, and its taste buds appeared shrunken and exhibited an atypical structure. While in group III, the papillae demonstrated better histological features, taste buds displayed cells with distinct boundaries; however, cytoplasmic degradation with irregular nuclei arrangement was evident in a few taste buds. Ki-67, NCAM, and SOD levels were significantly decreased in groups II & III compared to group I. However, group III exhibited a statistically significant increase compared to group II. Thus, it could be concluded that licorice extract might offer great potential as an anti-aging therapeutic compound to preserve function in the gustatory lingual papilla.

show abstract

Section: Discussionsupporting

confidence: 94%

The potential protective effect of licorice against age-related changes in the circumvallate papillae of albino rats

Farag,

El Moshy

2023

Egyptian Dental Journal

View full text Add to dashboard Cite

show abstract

“…While short-term treatment with genistein for 5 days result in a modest increase by less than 10% of plasma testosterone levels in Wistar rats [ 109 ], some have reported that a lifetime exposure to daidzein and genistein increases serum and testicular testosterone levels [ 110 ]. Others have shown that treatments with soy isoflavones daily for 8 weeks partially prevents the decrease in testosterone serum levels associated with aging in male rats [ 111 ]. However, a long-term consumption of daidzein and genistein impairs normal androgen production and reproductive function in male Wistar rats [ 112 ].…”

Section: Natural Antioxidants Contributing To the Optimal Production ...mentioning

confidence: 99%

Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants

Martin,

Touaibia

2024

Nutrients

View full text Add to dashboard Cite

Androgen production primarily occurs in Leydig cells located in the interstitial compartment of the testis. In aging males, testosterone is crucial for maintaining muscle mass and strength, bone density, sexual function, metabolic health, energy levels, cognitive function, as well as overall well-being. As men age, testosterone production by Leydig cells of the testes begins to decline at a rate of approximately 1% per year starting from their 30s. This review highlights recent findings concerning the use of natural polyphenolics compounds, such as flavonoids, resveratrol, and phenolic acids, to enhance testosterone production, thereby preventing age-related degenerative conditions associated with testosterone insufficiency. Interestingly, most of the natural polyphenolic antioxidants having beneficial effects on testosterone production tend to enhance the expression of the steroidogenic acute regulatory protein (Star) gene in Leydig cells. The STAR protein facilitates the entry of the steroid precursor cholesterol inside mitochondria, a rate-limiting step for androgen biosynthesis. Natural polyphenolic compounds can also improve the activities of steroidogenic enzymes, hypothalamus-pituitary gland axis signaling, and testosterone bioavailability. Thus, many polyphenolic compounds such as luteolin, quercetin, resveratrol, ferulic acid phenethyl ester or gigantol may be promising in delaying the initiation of late-onset hypogonadism accompanying aging in males.

show abstract

“…For example, glutathione depletion is known to result in a reduction in the ability of Leydig cells to generate testosterone levels via mechanisms that can be reversed by the presence of antioxidants ( Chen et al , 2008 ) or the activation of antioxidant pathways mediated by Sirt1 (sirtuin 1) and/or Nrf2 (nuclear factor erythroid 2) ( Chung et al , 2021 ) both of which become down-regulated with age ( Kopalli et al , 2019 ; Zhao et al , 2021 ). Antioxidants, or compounds that enhance endogenous antioxidant activity, such as the co-factor nicotinamide, have also been shown to enhance testosterone production in ageing rats and preserve the structural integrity of the testes ( Hacioglu et al , 2021 ; Al-Shaikh, 2022 ). Other putative antioxidants such as Korean red ginseng ( Kopalli et al , 2017 ), Cordycepin ( Kopalli et al , 2019 ), Gigantol ( Basque et al , 2021 ), and vitamin C ( Heidari et al , 2023 ) have similar effects.…”

Section: Paternal Ageing Testosterone and Oxidative Stressmentioning

confidence: 99%

“…For example, aged roosters supplemented with co-enzyme Q10 ( Sharideh et al , 2020 ), alpha lipoic acid ( Behnamifar et al , 2021 ), or selenium ( Sabzian-Melei et al , 2022 ) demonstrate positive responses in terms of semen quality and reproductive performance. In laboratory rats, taurine or soy isoflavone supplementation has been found to postpone the age-dependent decline in testicular function, elevating the protection afforded by antioxidant enzymes, as well as reducing ROS generation, DNA fragmentation, and lipid peroxidation ( Yang et al , 2015 ; Al-Shaikh, 2022 ). Cerium dioxide nanoparticles, which have powerful antioxidant properties, have also been shown to ameliorate the impact of ageing on the reproductive system of rats, increasing testosterone levels and improving the quality of spermatogenesis ( Kobyliak et al , 2015 ), while an antioxidant preparation from Ganoderma lucidum has a similar impact on mice ( Li et al , 2022 ).…”

Section: Oxidative Stress As the Common Denominatormentioning

confidence: 99%

Male reproductive ageing: a radical road to ruin

Aitken

2023

Human Reproduction

View full text Add to dashboard Cite

In modern post-transition societies, we are reproducing later and living longer. While the impact of age on female reproductive function has been well studied, much less is known about the intersection of age and male reproduction. Our current understanding is that advancing age brings forth a progressive decline in male fertility accompanied by a reduction in circulating testosterone levels and the appearance of age-dependent reproductive pathologies including benign prostatic hypertrophy and erectile dysfunction. Paternal ageing is also associated with a profound increase in sperm DNA damage, the appearance of multiple epigenetic changes in the germ line and an elevated mutational load in the offspring. The net result of such changes is an increase in the disease burden carried by the progeny of ageing males, including dominant genetic diseases such as Apert syndrome and achondroplasia, as well as neuropsychiatric conditions including autism and spontaneous schizophrenia. The genetic basis of these age-related effects appears to involve two fundamental mechanisms. The first is a positive selection mechanism whereby stem cells containing mutations in a mitogen-activated protein kinase pathway gain a selective advantage over their non-mutant counterparts and exhibit significant clonal expansion with the passage of time. The second is dependent on an age-dependent increase in oxidative stress which impairs the steroidogenic capacity of the Leydig cells, disrupts the ability of Sertoli cells to support the normal differentiation of germ cells, and disrupts the functional and genetic integrity of spermatozoa. Given the central importance of oxidative stress in defining the impact of chronological age on male reproduction, there may be a role for antioxidants in the clinical management of this process. While animal studies are supportive of this strategy, carefully designed clinical trials are now needed if we are to realize the therapeutic potential of this approach in a clinical context.

show abstract

Role of soy isoflavone in preventing aging changes in rat testis: Biochemical and histological studies

Cited by 9 publications

References 24 publications

The potential protective effect of licorice against age-related changes in the circumvallate papillae of albino rats

The potential protective effect of licorice against age-related changes in the circumvallate papillae of albino rats

Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants

Male reproductive ageing: a radical road to ruin

Contact Info

Product

Resources

About