Role of sound stimulation in reprogramming brain connectivity

Chaudhury, Sraboni; Nag, Tapas Chandra; Jain, Suman; Wadhwa, Shashi

doi:10.1007/s12038-013-9341-8

Cited by 29 publications

(26 citation statements)

References 110 publications

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“…Although initial formation of auditory cortex is normal in Fmr1 KO mice, mutants fail to undergo experience-dependent reorganization, suggesting an altered auditory critical period that is mGluR-dependent, as MPEP suppressed the sound-induced reorganization phenotype (Kim et al, 2013a). Sensory-dependent reorganization of auditory cortex has been explored at length, with A-D changes in hippocampus including neurogenesis, learning and memory, and neural connectivity (Chaudhury et al, 2013). …”

Section: Part 2: Activity-dependent Mechanisms In Asd Disease Statesmentioning

confidence: 99%

Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models

Doll

Broadie

2014

Front. Cell. Neurosci.

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Early-use activity during circuit-specific critical periods refines brain circuitry by the coupled processes of eliminating inappropriate synapses and strengthening maintained synapses. We theorize these activity-dependent (A-D) developmental processes are specifically impaired in autism spectrum disorders (ASDs). ASD genetic models in both mouse and Drosophila have pioneered our insights into normal A-D neural circuit assembly and consolidation, and how these developmental mechanisms go awry in specific genetic conditions. The monogenic fragile X syndrome (FXS), a common cause of heritable ASD and intellectual disability, has been particularly well linked to defects in A-D critical period processes. The fragile X mental retardation protein (FMRP) is positively activity-regulated in expression and function, in turn regulates excitability and activity in a negative feedback loop, and appears to be required for the A-D remodeling of synaptic connectivity during early-use critical periods. The Drosophila FXS model has been shown to functionally conserve the roles of human FMRP in synaptogenesis, and has been centrally important in generating our current mechanistic understanding of the FXS disease state. Recent advances in Drosophila optogenetics, transgenic calcium reporters, highly-targeted transgenic drivers for individually-identified neurons, and a vastly improved connectome of the brain are now being combined to provide unparalleled opportunities to both manipulate and monitor A-D processes during critical period brain development in defined neural circuits. The field is now poised to exploit this new Drosophila transgenic toolbox for the systematic dissection of A-D mechanisms in normal versus ASD brain development, particularly utilizing the well-established Drosophila FXS disease model.

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Section: Part 2: Activity-dependent Mechanisms In Asd Disease Statesmentioning

confidence: 99%

Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models

Doll

Broadie

2014

Front. Cell. Neurosci.

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“…Underlying those perceptual and behavioural effects, there is evidence that prenatal acoustic stimulation also alters neural development in the auditory system and associated brain regions, with broader consequences for cognition 17 , 18 . Specifically, pre- and perinatal exposure to species-specific sounds, music or noise has been shown in multiple species—including chickens, rats and humans—to modify neural connectivity and plasticity in several parts of the brain 15 , 18 , 19 , including the hippocampus, and to affect performance in cognitive tasks 17 , 20 . Importantly, the characteristics of the acoustic stimulus are crucial for predicting its effects, with rhythmic sounds, such as music, tending to improve cognitive performance, and arrhythmic sounds, such as noise, having the opposite effect (reviewed by Chaudhury 18 ).…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to incubation calls affects song learning in the zebra finch

Katsis

Davies

Buchanan

et al. 2018

Sci Rep

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Songbirds are important models for understanding the mechanisms and fitness consequences of imitative vocal learning. Although the effects of early-life environmental and social conditions on song learning are well-established, the impact of early sound exposure has received surprisingly little attention. Yet recent evidence hints at auditory sensitivity in songbird embryos, including in the zebra finch (Taeniopygia guttata), a classic model species for song learning. Here, we tested whether prenatal exposure to incubation calls—highly rhythmic parental vocalisations produced on the nest—affected song learning in zebra finches. Embryos were exposed in the egg to either incubation (treatment) or contact (control) calls, and after hatching were reared in a large colony. The playback treatment did not affect song complexity nor the accuracy of song copying from the social father, but instead increased learning of non-paternal song syllables. This, in turn, improved males’ mounting success in mating trials. These effects may be attributable to changes in juvenile social behaviours, as playback also influenced male behaviour during mating trials. Our study provides the first experimental evidence that prenatal acoustic environment affects song learning and courtship behaviour in songbirds, thereby raising interesting questions on the role of innate versus acquired biases for vocal learning.

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“…Research in mice showed that exposure to Mozart's composition during pregnancy can increase the density of dendrites in the cerebrum and cerebellum in offsprings Rattus norvegicus. 10,11,12 The research on the characteristics of the cerebrum and cerebellum that we performed obtained higher dendritic density in group with default sequence of Mozart composition when compared with group receiving reversed Mozart composition and without exposure. Dendrite density in the reversed sequence Mozart group had a higher value than in group without exposure.…”

Section: Analysis Of Results In Cerebellummentioning

confidence: 78%

Default sequence of Mozart’s compositions during pregnancy gave higher dendritic density in the cerebrum and cerebellum of Rattus norvegicus offsprings compared with reversed sequence and control

Panjaitan

Joewono

Widjiati

2019

MOG

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Objectives: This study aim to determine sequence of Mozart songs in the analyzing differences in dendritic density of cerebellum and cerebellum of new born Rattus novergicusMaterials and Methods: Experimental study randomized post test only control group design using Rattus norvegicus. Animal subjects were divided into three groups which were control group, and the treatment group that were given exposure to default sequence and reversed sequence of Mozart's music from gestation day 10. We used a comparison test in the analysis expression of BDNF.Results: In the cerebrum there was a significant difference in the Mozart group in reverse rather than with Mozart standard sequence and in standard Mozart group with no exposure group, with p=0.003 and p=0.000. In the cerebellum there was a significant difference in the group in reverse rather than with standard Mozart and in the standard Mozart group with the control group, with p=0.000 and p=0.000. However, there was no significant difference between control group and Mozart group upside down in cerebrum and cerebellum with p=0.109 and p=0.077Conclusion: The density of dendrites in the cerebrum and cerebellum of Rattus norvegicus newborn exposed to Mozart's music during pregnancy with standard Mozart sequence was higher than that in those receiving reverse order and without exposure. There were no significant differences between the density of the cerebrum and cerebellum dendrites between groups exposed to reversed sequence of Mozart composition and those without exposure.

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Role of sound stimulation in reprogramming brain connectivity

Cited by 29 publications

References 110 publications

Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models

Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models

Prenatal exposure to incubation calls affects song learning in the zebra finch

Default sequence of Mozart’s compositions during pregnancy gave higher dendritic density in the cerebrum and cerebellum of Rattus norvegicus offsprings compared with reversed sequence and control

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