Role of sortilin 1 (SORT1) on lipid metabolism in bovine liver

Yang, Wei; Wang, Shuang; Loor, Juan J.; Jiang, Qianming; Gao, Changhong; Yang, Mingmao; Tian, Yan; Fan, Wenwen; Zhao, Yingying; Zhang, Bingbing; Xu, Chuang

doi:10.3168/jds.2021-21607

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Among the studies, general issues related to the consideration of the participation of the autonomic nervous system on these indicators under different conditions or the use of different feed additives are considered (Yu et al, 2021;Yang et al, 2022b). These papers do not consider the individual characteristics of the animal when describing the autonomic nervous system as an indicator that is important in the development of stable homeostasis of the animal's body.…”

Section: Resultsmentioning

confidence: 99%

Influence of autonomic nervous system tone on the content of cholesterol and lipoproteins of different density in the blood of cows

Króliczewska,

Hryshchuk,

Karpovskyi

et al. 2023

Ukrainian journal of veterinary sciences

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The relevance of the study lies in the investigation of the influence of the autonomic nervous system tone on the content of lipids in the body of cows, which is important to consider in order to ensure the high productivity of the dairy herd and balance diets in animal feeding. The purpose of the study was to determine the effect of the tone of the ganglion nervous system on the content of cholesterol and lipoproteins of various densities in the blood of dairy cows of the Ukrainian Black-and-White breed. To determine heart rate variability, an electrocardiograph was used with subsequent measurement of the main indicators according to the Baevsky stress index, which included determining the mode, its amplitude, variation range, autonomous equilibrium index, autonomous rhythm indicator, and stress index. Three experimental groups were formed from experimental cows: normotonics, vagotonics, and sympathotonics. The content of lipoproteins in blood plasma was determined using a Sinnova BS-3000 biochemical analyser (China). According to the results of biochemical analysis, differences in the obtained indicators were established among experimental groups of cows with different tones of the autonomic nervous system. This is due to the fact that activation of the sympathetic nerve branch leads to changes in liver function, which affects the production of glucose in the body. This can lead to increased cholesterol production. In addition, an increased tone of the sympathetic branch can stimulate the activity of enzymes responsible for the synthesis of cholesterol, and lead to a decrease in the level of hormones that regulate its synthesis and transport in the body. In particular, vagotonic animals had the highest blood content of total cholesterol and high-density lipoproteins. Sympathotonics showed the lowest blood values for total cholesterol and high-density lipoproteins. Normotonics occupied an intermediate place among the experimental groups of cows. A detailed study of this issue reveals the features of the influence of the autonomic nervous system tone on the indicators of lipid metabolism in the blood of cows, which is important to consider in production to effectively solve issues related to maintaining their productivity and improving the quality of milk

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Section: Resultsmentioning

confidence: 99%

Influence of autonomic nervous system tone on the content of cholesterol and lipoproteins of different density in the blood of cows

Króliczewska,

Hryshchuk,

Karpovskyi

et al. 2023

Ukrainian journal of veterinary sciences

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Section: Normotonic Sympathotonic Vagotonicmentioning

confidence: 99%

Untitled

2023

Ukrainian journal of veterinary sciences

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In the production of broiler poultry products, market operators use intensive technologies that involve the use of various, environmentally friendly nutraceuticals, in particular, probiotic preparations. In the technology of raising broiler chickens, probiotic preparations are necessary as a means for the prevention and treatment of gastrointestinal diseases, stimulating the growth and increasing the productivity of poultry. The purpose of the study is to investigate the effect of probiotic biologics on haematological parameters when it is fed to broiler chickens. The experiment used 20 broiler chickens, which were given a probiotic from 28 to 42 days in the following amounts: 0.5 g/10 dm 3 , 2.0 and 4.0 g/10 dm 3 of water. It was found that the morpho-biochemical parameters of poultry blood corresponded to the physiological standards for broiler chickens of the established age and confirmed the absence of pathophysiological changes in their body. On days 35 and 42 of rearing, an increase in the number of leukocytes from 4.4 to 17.2% and the haemoglobin content by 3.9 and 6.2%, respectively, was observed in the blood of broiler chickens fed the probiotic at a dose of 4.0 g/10 dm 3 compared to the control group. On day 35 of the study, a 1.2-fold increase in total serum protein was observed when drinking a probiotic in poultry, respectively, at doses of 2.0 and 4.0 g/10 dm 3 of water, and on day 42 -1.0 times for its drinking at a dose of 4.0 g/10 dm 3 of water. It was found that the content of inorganic calcium and phosphorus in the poultry blood serum corresponded to physiological limits, which indicates a sufficient level of mineral nutrition in the body of broiler chickens. The absence of changes in the activity of alanine aminotransferase and aspartate aminotransferase, the content of total lipids, cholesterol, and creatinine in the blood serum of broiler chickens of the experimental groups indicates the hepato-and nephronethoxicity of the probiotic. Based on the results obtained, the drug under study can be recommended to increase the resistance of the poultry body and regulate metabolism

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