Abstract:Four strains belonging to the genus Curvularia were tested for their ability to transform progesterone to cortexolone and hydrocortisone. Curvularia lunata RCMB 019002 showed the greatest bioconversion efficiency (29.64%). In a medium containing (g/l); yeast extract 4 and malt extract 20, the substrate was converted after 48h to cortexolone and cortisol. The maximum bioconversion efficiency (37. 72%) was recorded when phosphate buffer was used at pH 7.0. The transformation pattern of progesterone markedly affe… Show more
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