Role of somatostatin in the regulation of vasopressin secretion

Brown, Marvin R.; Mortrud, Marty; Crum, Ralph; Sawchenko, Paul E.

doi:10.1016/0006-8993(88)90025-x

Cited by 21 publications

(8 citation statements)

References 27 publications

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“…For example, we detected specific enrichment for relaxin-1 ( Rln1 ; 3.7-fold), a neuropeptide that stimulates water intake (Thornton and Fitzsimons, 1995) and activates vasopressin and oxytocin neurons (Sunn et al, 2002) but that had not been characterized in the hypothalamus due to its low expression level. Other enriched neuropeptides include urocortin 3 ( Ucn3 ; 5.4-fold), which is related to Crh and is expressed in a small population of neurons in the perifornical region, and somatostatin ( Sst ; 3.4-fold), which is known to promote vasopressin release (Brown et al, 1988). …”

Section: Resultsmentioning

confidence: 99%

Molecular Profiling of Activated Neurons by Phosphorylated Ribosome Capture

Knight

Tan

Birsoy

et al. 2012

Cell

296

342

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SUMMARY The mammalian brain is composed of thousands of interacting neural cell types. Systematic approaches to establish the molecular identity of functional populations of neurons would advance our understanding of neural mechanisms controlling behavior. Here, we show that ribosomal protein S6, a structural component of the ribosome, becomes phosphorylated in neurons activated by a wide range of stimuli. We show that these phosphorylated ribosomes can be captured from mouse brain homogenates, thereby enriching directly for the mRNAs expressed in discrete subpopulations of activated cells. We use this approach to identify neurons in the hypothalamus regulated by changes in salt balance or food availability. We show that galanin neurons are activated by fasting and that prodynorphin neurons restrain food intake during scheduled feeding. These studies identify elements of the neural circuit that controls food intake and illustrate how the activity-dependent capture of cell-type-specific transcripts can elucidate the functional organization of a complex tissue.

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Section: Resultsmentioning

confidence: 99%

Molecular Profiling of Activated Neurons by Phosphorylated Ribosome Capture

Knight

Tan

Birsoy

et al. 2012

Cell

296

342

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“…Intracerebroventricular injection of Oct also regularly elicited prompt drinking (1). Previous reports indicate that intracerebroventricularly injected somatostatin induces vasopressin secretion and blood pressure increase in the rat (4,5,35). Drinking, vasopressin release, and blood pressure increase are well-documented responses to intracerebroventricularly administered ANG II and cholinergic agonists, e.g., carbachol (6, 11, 14-16, 29, 30).…”

mentioning

confidence: 90%

Octreotide-induced drinking, vasopressin, and pressure responses: role of central angiotensin and ACh

Hajdu

Obál²,

Gardi

et al. 2000

American Journal of Physiology-Regulatory, Integrative and Comp

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The involvement of central angiotensinergic and cholinergic mechanisms in the effects of the intracerebroventricularly injected somatostatin analog octreotide (Oct) on drinking, blood pressure, and vasopressin secretion in the rat was investigated. Intracerebroventricular Oct elicited prompt drinking lasting for 10 min. Water consumption depended on the dose of Oct (0.01, 0.1, and 0. 4 microgram). The drinking response to Oct was inhibited by pretreatments with the intracerebroventricularly injected angiotensin-converting enzyme inhibitor captopril, the AT(1)/AT(2) angiotensin receptor antagonist saralasin, the selective AT(1) receptor antagonist losartan, or the muscarinic cholinergic receptor antagonist atropine. The dipsogenic effect of Oct was not altered by prior subcutaneous injection of naloxone. Oct stimulated vasopressin secretion and enhanced blood pressure. These responses were also blocked by pretreatments with captopril or atropine. Previous reports indicate that the central angiotensinergic and cholinergic mechanisms stimulate drinking and vasopressin secretion independently. We suggest that somatostatin acting on sst2 or sst5 receptors modulates central angiotensinergic and cholinergic mechanisms involved in the regulation of fluid balance.

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“…Somatostatin has been implicated in behavioural changes during rat pregnancy and post‐partum, because somatostatin binding in the frontoparietal cortex significantly decreases at day 17 of pregnancy and increases again on the expected day of delivery (10). Given centrally, somatostatin and analogues elicit vasopressin release, changes in blood pressure and behavioural effects, including drinking (2, 3, 11–14).…”

mentioning

confidence: 99%

Somatostatin Actions on Rat Supraoptic Nucleus Oxytocin and Vasopressin Neurones

Meddle

Bull

Leng

et al. 2010

J Neuroendocrinology

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Magnocellular neurones in the supraoptic nucleus (SON) receive major afferent inputs from the brainstem that have been implicated in the regulation of oxytocin and vasopressin secretion from the posterior pituitary. Notably, at parturition, some neurones that project from the nucleus tractus solitarii (NTS) in the brainstem directly to the SON are activated. Many of these are noradrenergic and regulate oxytocin secretion during parturition, whereas others contain somatostatin and their role is unclear. In the present study, we report that, at parturition, somatostatin mRNA expression in the NTS is significantly increased compared to pregnancy, suggesting an active role for these neurones at that time. Intracerebroventricular somatostatin infusion significantly increased plasma oxytocin secretion in both virgin female and pregnant rats. Intracerebroventricular somatostatin increased SON oxytocin and vasopressin neurone firing-rates, and increased Fos expression in the SON and paraventricular nucleus and in the subfornical organ. Retrodialysis of somatostatin onto the ventrally exposed SON also increased vasopressin neurone firing rate but, unexpectedly, decreased oxytocin neurone firing rate. The experiments indicate that somatostatin neurones in the NTS are activated during parturition but, because the direct effects of somatostatin on oxytocin neurones are inhibitory, this direct pathway does not appear to contribute to enhanced oxytocin release at this time, although indirect somatostatin effects may do so.

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Role of somatostatin in the regulation of vasopressin secretion

Cited by 21 publications

References 27 publications

Molecular Profiling of Activated Neurons by Phosphorylated Ribosome Capture

Molecular Profiling of Activated Neurons by Phosphorylated Ribosome Capture

Octreotide-induced drinking, vasopressin, and pressure responses: role of central angiotensin and ACh

Somatostatin Actions on Rat Supraoptic Nucleus Oxytocin and Vasopressin Neurones

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