Role of smoking in functional dyspepsia and irritable bowel syndrome: three random population‐based studies

Talley, Nick; Powell, Nicholas; Walker, Marjorie M.; Jones, Michael; Ronkainen, Jukka; Forsberg, Anna; Kjellström, Lars; Hellström, Per M.; Aro, Pertti; Wallner, Bengt; Agréus, Lars; Andréasson, Anna

doi:10.1111/apt.16372

Cited by 26 publications

(21 citation statements)

References 40 publications

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“…Psychological factors, in particular anxiety, have been reported to be associated with future development of FD in several longitudinal follow-up studies. 34 35 121 A pooled analysis of three population-based studies also identified smoking as a risk factor for PDS, 122 but not EPS. Evidence for any contribution of other lifestyle factors is conflicting.…”

Section: Presentation Of Fd Diagnosis and Management In Primary Carementioning

confidence: 99%

British Society of Gastroenterology guidelines on the management of functional dyspepsia

Black

Paine

Agrawal

et al. 2022

Gut

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Functional dyspepsia (FD) is a common disorder of gut–brain interaction, affecting approximately 7% of individuals in the community, with most patients managed in primary care. The last British Society of Gastroenterology (BSG) guideline for the management of dyspepsia was published in 1996. In the interim, substantial advances have been made in understanding the complex pathophysiology of FD, and there has been a considerable amount of new evidence published concerning its diagnosis and classification, with the advent of the Rome IV criteria, and management. The primary aim of this guideline, commissioned by the BSG, is to review and summarise the current evidence to inform and guide clinical practice, by providing a practical framework for evidence-based diagnosis and treatment of patients. The approach to investigating the patient presenting with dyspepsia is discussed, and efficacy of drugs in FD summarised based on evidence derived from a comprehensive search of the medical literature, which was used to inform an update of a series of pairwise and network meta-analyses. Specific recommendations have been made according to the Grading of Recommendations Assessment, Development and Evaluation system. These provide both the strength of the recommendations and the overall quality of evidence. Finally, in this guideline, we consider novel treatments that are in development, as well as highlighting areas of unmet need and priorities for future research.

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Section: Presentation Of Fd Diagnosis and Management In Primary Carementioning

confidence: 99%

British Society of Gastroenterology guidelines on the management of functional dyspepsia

Black

Paine

Agrawal

et al. 2022

Gut

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“…Additionally, smoking was associated with a significantly increased risk of IBS-diarrhea, while this only applied to the highest exposure category (20 or more cigarettes per day), there was a trend for a dose-response relationship. On the other hand, there was no relationship between IBS-C and IBS-M 20 . A systematic review found that the reported prevalence of constipation was 2.6-26.9% 21 .…”

Section: Discussionmentioning

confidence: 73%

“…Hence, the high prevalence of constipation and IBS-C (52.2%) was unexpected, suggesting that symptoms of constipation may be more common in current smokers than in the general population. Still, Talley et al 20 found that heavy smokers had significantly higher odds of diarrhea, flatus, urgency than nonsmokers. Additionally, smoking was associated with a significantly increased risk of IBS-diarrhea, while this only applied to the highest exposure category (20 or more cigarettes per day), there was a trend for a dose-response relationship.…”

Section: Discussionmentioning

confidence: 99%

Frequency and severity of irritable bowel syndrome in cigarette smokers, Turkey 2019

Başpınar¹,

Basat²

2022

Tob. Induc. Dis.

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INTRODUCTION Cigarette smoking has recently been associated with several gastrointestinal symptoms, and smoking cessation has been recommended as a lifestyle change strategy for irritable bowel syndrome (IBS). This study assessed the prevalence of IBS in cigarette smokers based on the Rome IV criteria, the severity of nicotine dependence, and the effect of smoking cessation in smokers with IBS. METHODS This prospective study included 371 smokers who attended smoking cessation treatment at family medicine clinics in a tertiary hospital between January and April 2019, in Turkey. Data on demographic characteristics, IBS status according to the Rome IV criteria, and Fagerström test for nicotine dependence (FTND) scores were collected during face-to-face interviews. RESULTS The mean patient age was 40.7 ± 11.96 years. Out of the total patients, 29.4% were heavy smokers, and 18.1% had IBS. There was a significant difference in age (p=0.03), duration of smoking (p=0.05), FTND score (p=0.02), and sex (p<0.001) between those with and without IBS. Logistic regression analyses identified female sex as a predictor of IBS in smokers (adjusted odds ratio, AOR=1.78; 95% CI: 1.18-2.69; p=0.006). At follow-up at 1 year, IBS(+) smokers who had quit smoking showed decreased gastrointestinal symptoms (p=0.035). CONCLUSIONS FTND score was higher in IBS(+) smokers than in IBS(-) smokers. Smoking cessation ameliorated gastrointestinal symptoms but did not affect IBS status.

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“…Thirdly, we harmonized the respective exposure and outcome datasets using effect allele frequencies, while removing palindromic SNPs with intermediate allele frequencies. Lastly, according to the third assumption of MR that genetic variation cannot be associated with any possible confounding factor, we used PhenoScanner V2 [ 21 ] (a database of human genotype–phenotype associations) to search the SNPs and exclude those associated ( p < 1 × 10 −5 ) with confounding factors such as drinking [ 22 ], smoking [ 23 ], depression, and anxiety [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

The Role of Calcium, 25-Hydroxyvitamin D, and Parathyroid Hormone in Irritable Bowel Syndrome: A Bidirectional Two-Sample Mendelian Randomization Study

Xie

Wang

et al. 2022

Nutrients

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Several observational studies have indicated the potential associations among calcium, vitamin D (Vit-D), and irritable bowel syndrome (IBS). However, the causal relationship deduced from these studies is subject to residual confounding factors and reverse causation. Therefore, we aimed to explore the bidirectional causal effects among serum calcium, Vit-D, PTH, and IBS at the genetic level by a two-sample Mendelian randomization (MR) analysis of the datasets from IEU OpenGWAS database. Sensitivity analyses were performed to evaluate the robustness. The estimates were presented as odds ratios (ORs) with their 95% confidence intervals (CIs). The results of the inverse variance weighted method did not reveal any causal relationship between the genetically predisposed calcium (OR = 0.92, 95% CI: 0.80–1.06, p = 0.25) and Vit-D (OR = 0.99, 95% CI: 0.83–1.19, p = 0.94) level and the risk of IBS. The bidirectional analysis demonstrated that genetic predisposition to IBS was associated with a decreased level of PTH (beta: −0.19, 95%CI: −0.34 to −0.04, p = 0.01). In conclusion, the present study indicates no causal relationship between the serum calcium and Vit-D concentrations and the risk of IBS. The potential mechanisms via which IBS affects serum PTH need to be further investigated.

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Role of smoking in functional dyspepsia and irritable bowel syndrome: three random population‐based studies

Cited by 26 publications

References 40 publications

British Society of Gastroenterology guidelines on the management of functional dyspepsia

British Society of Gastroenterology guidelines on the management of functional dyspepsia

Frequency and severity of irritable bowel syndrome in cigarette smokers, Turkey 2019

The Role of Calcium, 25-Hydroxyvitamin D, and Parathyroid Hormone in Irritable Bowel Syndrome: A Bidirectional Two-Sample Mendelian Randomization Study

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