2006
DOI: 10.1001/archderm.142.2.175
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Role of Skin Biopsy to Confirm Suspected Acute Graft-vs-Host Disease

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Cited by 65 publications
(43 citation statements)
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“…The diagnosis of GVHD can be made on clinical indications and biopsy (17) but is facilitated by demonstrating donor lymphoid chimerism. A value greater than 20% more than 1-week posttransplant is highly specific (2).…”
Section: Discussionmentioning
confidence: 99%
“…The diagnosis of GVHD can be made on clinical indications and biopsy (17) but is facilitated by demonstrating donor lymphoid chimerism. A value greater than 20% more than 1-week posttransplant is highly specific (2).…”
Section: Discussionmentioning
confidence: 99%
“…Firoz et al [13] weighted the benefitrisk ratio of appropriate vs inappropriate treatment of GVHD, demonstrating in a hypothetical cohort of patients with suspected acute cutaneous GVHD after HSCT, that if the prevalence of GVHD is 30% or greater, the best outcome is obtained when patients are treated immediately without performing a skin biopsy. Otherwise, if prevalence is less than 30%, the best outcome is provided by a skin biopsy analysis before treatment [13]. In addition, failure to obtain prior histologic confirmation of cGvHD resulted in 7% of the referral patients being incorrectly diagnosed and treated for GvHD before their arrival [28].…”
Section: Discussionmentioning
confidence: 99%
“…The cutaneous manifestations of cGvHD are protean and have been recently revised by an expert panel at the NIH Consensus Conference in 2005 [6]. Criteria for the histopathologic diagnosis of GvHD have been modified over time [7][8][9][10][11], and the clinical value of biopsies for GvHD management is controversial [7,[12][13][14], especially within the first 3 weeks following bone marrow transplantation [15], a time during which histopathologic features are virtually indistinguishable from those due to non-GvHD-related conditions, like viral infections, drug reactions, engraftment syndrome associated with lymphocyte recovery, and toxicity from the pretransplant cytoreductive conditioning.…”
Section: Introductionmentioning
confidence: 99%
“…Aufgrund der Variabilität des histopathologischen Bildes ist weniger die Spezifität dieser Untersuchung als vielmehr die Sensitivität in Zusammenschau aller Befunde für eine Diagnosefindung von entscheidender Bedeutung [14].…”
Section: Bedeutung Der Hautbiopsie Bei Verdacht Auf Akute Gvhdunclassified