Role of Single Nucleotide Fibronectin Polymorphisms in Pathogenesis of Bronchopulmonary Dysplasia

Abstract

Background Bronchopulmonary dysplasia (BPD) is a chronic lung disease that mainly affects premature newborns. Many different factors, increasingly genetic, are involved in the pathogenesis of BPD. Fibronectin is a multi-domain glycoprotein present in nearly all vertebrate tissues and organs. Material and methods The study included 108 infants born between 24 and 32 weeks of gestation. BPD was diagnosed based on the National Institutes of Health Consensus definition. The 5 FN1 gene polymorphisms assessed in the study were the following: rs3796123; rs1968510; rs10202709; rs6725958; and rs35343655.Results BPD developed in 30 (38.5%) out of the 108 preterm infants. Incidence of BPD was higher in infants with lower APGAR scores, low gestational age, and low birthweight. Investigation did not confirm any significant prevelance for BPD development in any genotypes and alleles of FN1. Conclusion Further studies should be performed to confirm the role of genetic factors in etiology and pathogenesis of BPD.