Role of Signaling Pathways in the Viral Life Cycle 2.0

Abstract

Viral infections can lead to the generation of new virus particles, whereas other viruses behave as chameleons by camouflaging themselves to evade or mislead the immune system of the host, thereby establishing a latent infection [...]

Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans

“…Viruses and associated host responses are known to manipulate and alter cellular signal transduction pathways. 32 Additionally, many viruses have been shown to recruit and/or directly bind to eIF3—a protein complex important to translation initiation—that include Ebola, rabies and hepatitis C viruses. 33 , 34 , 35 , 36 From the host response side, interferon-induced protein with tetratricopeptide repeats (IFIT) has been shown to inhibit HCV replication via eIF3 targeting.…”