Role of signal transduction pathways in IL‐1β‐induced apoptosis: Pathological and therapeutic aspects

Abstract

Background: Interleukin-1β (IL-1β) is a pro-inflammatory cytokine mainly produced by monocytes and macrophages with a wide range of biological effects. Evidence has shown that IL-1β plays a vital role in the process of apoptosis; however, the specific mechanisms, by which IL-1β induces apoptosis, vary due to different cellular and experimental conditions. Therefore, this present reviewstudy aimed to systematically review the association between the molecular mechanisms of IL-1β-induced apoptosis in pathological processes and the role of signaling pathways. This article also sought to briefly investigate the potential of signaling pathway-targeted therapy in the prevention and treatment of disease. Methods: This is a literature review article. The present discourse aim is first to scrutinize and assess the available literature on IL-1β and apoptosis. The relevant studies using the keywords of "IL-1β-induced apoptosis" and "signaling pathways" were searched in the databases of PubMed, Scopus, Google Scholar, and Web of Science. Gathered relevant material, and extracted information was then assessed. Results: IL-1β can induce apoptosis in various types of cells under different external stimuli via the mitochondrial pathway, death receptor pathway and endoplasmic reticulum pathway, and that the different pathways are often interconnected. The NF-KB signaling pathway, p38MAPK, and JNK signaling pathways mainly play a proapoptotic part, and the ERK1/2 pathway has a bidirectional role in regulating apoptosis, while activation of the PI3K-Akt signaling pathway can inhibit apoptosis. Conclusion: This review indicates that IL-1β-induced apoptosis plays an important role in pathogenesis and development of pathology of many inflammatory diseases. Elucidating the role of the signaling pathways will aid the development of targeted therapeutic treatments.

Interleukin 1β receptor blocker (Anakinra) and regenerative stem cell therapy: two novel approaches effectively ameliorating diabetic cardiomyopathy

“…A positive feedback loop develops between TNFα, NF-κB, and IL1β, accentuating leukocyte formation with further activation of inflammation and apoptosis (Kaur et al 2021). Supporting this, the predominance of M1 macrophages in DM and its role in promoting DCM has been previously reported (Lehrke et al 2004;Wang et al 2023;Coggins and Rosenzweig 2012).…”

Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation

“…The inhibition of NLRP3 inflammasome can lead to the decreased expression of IL-1β (30). Consequently, the IL-1βinduced apoptosis can be alleviated through NF-κB, MAPKs and PI3K/Akt signaling pathway (31). In our previous study (16), we also found melatonin inhibited NLRP3 inflammasome to relieve apoptosis in DCD hearts.…”

Inflammatory responses in esophageal mucosa before and after laparoscopic antireflux surgery

“…Overactivity of these pathways results in NFκB activation and subsequently increased levels of pro-inflammatory cytokines, especially IL1β and IFNγ. In our study, the elevated IL1β levels may have been regulated by these two pathways and NFκB[ 14 , 15 ].…”