Role of sialyl 6‐sulfo Lewis X in antitumor immunity against oral squamous cell carcinoma

Yoshida, Hisato; Hoshino, Hiroo; Imamura, Yoshiaki; Yoshimura, Hitoshi; Sano, Kazuo; Kobayashi, Motohiro

doi:10.1111/jop.12585

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…We previously demonstrated induction of HEV-like vessels in chronic inflammatory conditions, including chronic Helicobacter pylori gastritis, 15 –17 ulcerative colitis, 18,19 autoimmune pancreatitis, 20 chronic prostatitis associated with benign prostatic hyperplasia, 21 and eosinophilic chronic rhinosinusitis, 22 as well as in malignant tumors including bladder urothelial carcinoma 23 and oral squamous cell carcinoma. 24 In these studies, we detected PNAd on HEV-like vessels using the monoclonal antibody MECA-79, whose epitope is known to be 6-sulfo N -acetyllactosamine attached to extended core 1 O -glycans, 25,26 which overlaps with sialyl 6-sulfo Lewis X, the L-selectin recognition determinant. Here, we performed quantitative immunohistochemical analysis of a total of 36 LP cases (19 OLP and 17 CLP) to assess induction of PNAd-expressing HEV-like vessels.…”

Section: Introductionmentioning

confidence: 99%

Induction of High Endothelial Venule–like Vessels in Oral and Cutaneous Lichen Planus: A Comparative Study

Yoshida

Imamura

Yoshimura

et al. 2020

J Histochem Cytochem.

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Lichen planus (LP) is a chronic inflammatory mucocutaneous disease involving the oral mucosa and skin. Both oral LP (OLP) and cutaneous LP (CLP) are histopathologically characterized by dense subepithelial lymphocyte infiltrates; however, the mechanisms underlying lymphocyte recruitment to sites of LP lesions are not fully understood. Here, we assessed the induction of peripheral lymph node addressin (PNAd)-expressing high endothelial venule (HEV)-like vessels in 19 OLP and 17 CLP cases. To do so, we performed immunohistochemical staining for PNAd and CD34, followed by quantitative analysis. We also conducted triple immunohistochemistry for PNAd and either CD3 and CD20 or CD4 and CD8 to identify the lymphocyte subset preferentially recruited via HEV-like vessels. PNAd-expressing HEV-like vessels were induced in and around lymphocyte aggregates in all cases of OLP and in 10 of 17 CLP cases, and these vessels were more frequently observed in OLP relative to CLP. Although the number of T-cells attached per HEV-like vessel exceeded the number of B-cells in both OLP and CLP, the number of CD4+ T-cells attached was greater than the number of CD8+ T-cells only in OLP. These findings combined suggest that PNAd-expressing HEV-like vessels play a more important role in the pathogenesis of OLP compared with CLP.

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Section: Introductionmentioning

confidence: 99%

Induction of High Endothelial Venule–like Vessels in Oral and Cutaneous Lichen Planus: A Comparative Study

Yoshida

Imamura

Yoshimura

et al. 2020

J Histochem Cytochem.

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“…The presence of HEVs has been reported in oral lesions with malignant potential ( 53 , 54 ), but HEV development at different stages of oral cancer development and progression is not well described. In OSCC, HEVs are more frequently found in early-stage tumors (T1-T2) than advanced tumors (T3-T4) ( 21 , 55 ). Here we showed that the number of HEVs increased significantly during progression of tongue lesions, suggesting that early changes in the tongue mucosa initiates HEV formation that is maintained during tumor initiation and progression.…”

Section: Discussionmentioning

confidence: 99%

4-nitroquinoline 1-oxide-induced oral epithelial lesions exhibit time- and stage-dependent changes in the tumor immune microenvironment

Sellæg,

Schwienbacher,

Kranz

et al. 2024

Front. Oncol.

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Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity and is associated with high morbidity due to local invasion and lymph node metastasis. Tumor infiltrating lymphocytes (TILs) are associated with good prognosis in oral cancer patients and dictate response to treatment. Ectopic sites for immune activation in tumors, known as tertiary lymphoid structures (TLS), and tumor-associated high-endothelial venules (TA-HEVs), which are specialized lymphocyte recruiting vessels, are associated with a favorable prognosis in OSCC. Why only some tumors support the development of TLS and HEVs is poorly understood. In the current study we explored the infiltration of lymphocyte subsets and the development of TLS and HEVs in oral epithelial lesions using the 4-nitroquinoline 1-oxide (4NQO)-induced mouse model of oral carcinogenesis. We found that the immune response to 4NQO-induced oral epithelial lesions was dominated by T cell subsets. The number of T cells (CD4+, FoxP3+, and CD8+), B cells (B220+) and PNAd+ HEVs increased from the earliest to the latest endpoints. All the immune markers increased with the severity of the dysplasia, while the number of HEVs and B cells further increased in SCCs. HEVs were present already in early-stage lesions, while TLS did not develop at any timepoint. This suggests that the 4NQO model is applicable to study the dynamics of the tumor immune microenvironment at early phases of oral cancer development, including the regulation of TA-HEVs in OTSCC.

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Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances

Zhao,

Jin,

Wang

et al. 2024

Sig Transduct Target Ther

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Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs (SLOs), the formation of TLSs relies on the interaction between lymphoid tissue inducer (LTi) cells and lymphoid tissue organizer (LTo) cells, involving multiple cytokines. Heterogeneity is a distinguishing feature of TLSs, which may lead to differences in their functions. Growing evidence suggests that TLSs are associated with various diseases, such as cancers, autoimmune diseases, transplant rejection, chronic inflammation, infection, and even ageing. However, the detailed mechanisms behind these clinical associations are not yet fully understood. The mechanisms by which TLS maturation and localization affect immune function are also unclear. Therefore, it is necessary to enhance the understanding of TLS development and function at the cellular and molecular level, which may allow us to utilize them to improve the immune microenvironment. In this review, we delve into the composition, formation mechanism, associations with diseases, and potential therapeutic applications of TLSs. Furthermore, we discuss the therapeutic implications of TLSs, such as their role as markers of therapeutic response and prognosis. Finally, we summarize various methods for detecting and targeting TLSs. Overall, we provide a comprehensive understanding of TLSs and aim to develop more effective therapeutic strategies.

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Role of sialyl 6‐sulfo Lewis X in antitumor immunity against oral squamous cell carcinoma

Abstract: Sialyl 6-sulfo LeX is displayed not only on HEV-like vessels but also on OSCC cells and may potentially function in antitumor immunity against OSCC.

Cited by 4 publications

References 29 publications

Induction of High Endothelial Venule–like Vessels in Oral and Cutaneous Lichen Planus: A Comparative Study

Induction of High Endothelial Venule–like Vessels in Oral and Cutaneous Lichen Planus: A Comparative Study

4-nitroquinoline 1-oxide-induced oral epithelial lesions exhibit time- and stage-dependent changes in the tumor immune microenvironment

Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances

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