Role of Shape in Particle-Lipid Membrane Interactions: From Surfing to Full Engulfment
Stijn van der Ham,
Jaime Agudo-Canalejo,
Hanumantha Rao Vutukuri
Abstract:Understanding and manipulating the interactions between foreign bodies and cell membranes during endo-and phagocytosis is of paramount importance, not only for the fate of living cells but also for numerous biomedical applications. This study aims to elucidate the role of variables such as anisotropic particle shape, curvature, orientation, membrane tension, and adhesive strength in this essential process using a minimal experimental biomimetic system comprising giant unilamellar vesicles and rod-like particle… Show more
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