Role of Serum Vitamin D, Interleukin 13, and microRNA-135a in Hepatocellular Carcinoma and Treatment Failure in Egyptian HCV-Infected Patients Receiving Direct Antiviral Agents

Ali, Marfoua S.; Halby, Hamada Mohamed; Ali, Mamdouh; Hassan, Elham Ahmed; El‐Mokhtar, Mohamed A.; Sayed, Ibrahim M.; Thabet, Marwa M.; Fouad, Magdy; El-Ashmawy, Ahmed; Mahran, Zainab Gaber

doi:10.3390/v13102008

Cited by 4 publications

(2 citation statements)

References 109 publications

(121 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A meta-analysis concluded by Hu et al represent that CHB patients display lower vitamin D levels compared to healthy individuals, with lower vitamin D status being more frequent in patients with high viral load. Other studies suggest vitamin D as a marker for HCC development (18,26).…”

Section: Vitamin D and Viral Loadmentioning

confidence: 99%

Association of viral load and autophagy-related genes polymorphisms with hepatitis B virus pre-core/core mutations in chronic hepatitis B virus Iraqi patients

Jwaziri,

Esghaei,

Karbalaie Niya

et al. 2023

Immunopathol Persa

View full text Add to dashboard Cite

Introduction: Chronic hepatitis B (CHB) is a global concern due to its association with cirrhosis and hepatocellular carcinoma (HCC) development. The interplay between viral load, the immune system, and host factors is critical in tumorigenesis. Autophagy is a significant contributor to immune system function, since vitamin D plays an important role in this context. Objectives: The objective of this study was to assess the association between ATG5 (rs506027 and rs510432) and ATG16L1 (rs2241880 and ATG16 rs2241879) polymorphisms, viral load, and vitamin D with HBV pre-C/C mutations in Iraqi patients with CHB. Patients and Methods: In this cross-sectional study, a total of 134 CHB patients were evaluated for ATG polymorphisms, viral load, and vitamin D levels. Blood samples were collected after obtaining ethical consent, and the mutations were analyzed using polymerase chain reaction (PCR) followed by Sanger sequencing. Serum samples from CHB patients were used for viral load and vitamin D assessment. Results: The evaluation of patients revealed that 67 (44.6%) were male and 83 (55.4%) were female, with a mean age of 36±12.7 years and a mean duration of infection of 5.2±4.8 years. Mutations in pre-C/C were observed in 20% (27/134) of the patients. There was a significant association between all evaluated ATG polymorphisms and pre-C/C mutants (P<0.05). Furthermore, there was an association between viral load and mutations in pre-C/C (P=0.03), while no statistically significant difference was found between vitamin D levels and pre-core/core mutants or viral load. Conclusion: Our study demonstrates a higher frequency of ATG5 (rs506027 and rs510432) and ATG16L1 (rs2241880 and ATG16 rs2241879) polymorphisms, as well as a higher viral load in Iraqi CHB patients with HBV pre-C/C mutations.

show abstract

Section: Vitamin D and Viral Loadmentioning

confidence: 99%

Association of viral load and autophagy-related genes polymorphisms with hepatitis B virus pre-core/core mutations in chronic hepatitis B virus Iraqi patients

Jwaziri,

Esghaei,

Karbalaie Niya

et al. 2023

Immunopathol Persa

View full text Add to dashboard Cite

show abstract

“…Moreover, numerous challenges still remain in HCV treatment, such as barriers to screening, linkage to care, access to medication, and high pharmaceutical costs. In a study conducted on Egyptian HCV-infected patients receiving DAAs, a direct association was shown between prognostic markers such as interlukin-13, vitamin D, and the expression of miR-135a with treatment failure and hepatocellular carcinoma (HCC) development (Ali et al) [ 7 ].…”

mentioning

confidence: 99%