Role of serum procalcitonin in the diagnosis and monitoring of treatment response in treatment-naïve subjects with chronic pulmonary aspergillosis

Sehgal, Inderpaul Singh; Dhooria, Sahajal; Sachdeva, Naresh; Rudramurthy, Shivaprakash M; Prasad, Kuruswamy Thurai; Muthu, Valliappan; Aggarwal, Ashutosh N.; Garg, Mandeep; Chakrabarti, Arunaloke; Agarwal, Ritesh

doi:10.1016/j.heliyon.2023.e15356

Cited by 4 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conversely, PCT exhibits a slight increase in fungal infections, but studies on its role are limited. In chronic pulmonary aspergillosis, the diagnostic and monitoring efficacy of PCT is modest ( Sehgal et al., 2023 ). Our study linked elevated PCT levels to the need for assisted ventilation and extended hospital stays.…”

Section: Discussionmentioning

confidence: 99%

Improved diagnostic markers for invasive pulmonary aspergillosis in COPD patients

Long,

Li,

et al. 2024

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

BackgroundThe prevalence of invasive pulmonary aspergillosis (IPA) among patients with chronic obstructive pulmonary disease (COPD) is steadily increasing, leading to high mortality. Although early diagnosis can significantly reduce mortality, the efficacy of current diagnostic methods is limited. Consequently, there is a need for novel approaches for early IPA detection.MethodsThis retrospective study involved 383 hospitalized COPD patients with GOLD stages III and IV. The IPA group (67 patients) and non-IPA group (316 patients) were identified at the First Affiliated Hospital of Guangzhou Medical University between January 2016 and February 2022. We analyzed common serological indicators in our hospital to identify predictive indicators for the early diagnosis of IPA in COPD patients.ResultsThe sensitivity and specificity of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), lactate dehydrogenase (LDH), and ceruloplasmin (CER) for diagnosing IPA in COPD patients were as follows: CRP (91.2%, 57.7%), ESR (77.5%, 73.0%), PCT (60.5%, 71.4%), LDH (50.0%, 88.8%), and CER (60.7%, 74.3%). Combinations of biomarkers, such as CRP-ESR, CRP-LDH, ESR-LDH, ESR-CER, and LDH-CER, showed promising diagnostic potential, with larger area under the curve (AUC) values for IPA diagnosis in COPD patients. However, no statistically significant difference was observed between the diagnostic efficacy of single biomarkers and combined biomarkers. Notably, compared to those in the unassisted ventilation group, the patients in the assisted ventilation group (including noninvasive ventilation and tracheal intubation/incision-assisted ventilation group) exhibited significantly greater PCT and LDH levels, while the CER significantly decreased (p=0.021). There were no significant differences in biomarker levels between the ICU group and the non-ICU group. CRP (p<0.01), ESR (p=0.028), PCT (p<0.01), and CER (p<0.01) were positively correlated with hospitalization duration, whereas LDH was not correlated with hospitalization duration.ConclusionOur study highlights the diagnostic potential of CRP, ESR, PCT, LDH, and CER for IPA in COPD patients. CRP and LDH can also initially predict the need for assisted ventilation, while CRP can initially estimate the length of hospitalization. This study represents the first report of the potential of CER for diagnosing IPA, suggesting its significance for further research.

show abstract

Section: Discussionmentioning

confidence: 99%

Improved diagnostic markers for invasive pulmonary aspergillosis in COPD patients

Long,

Li,

et al. 2024

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…(2) presence of systemic (fever, weight loss, anorexia, malaise and fatigue) or respiratory (cough, expectoration, dyspnea, chest pain and hemoptysis) symptoms for at least 3 months; (3) evidence of Aspergillus infection (≥2 sputum cultures or one bronchoalveolar lavage fluid showing Aspergillus species, A. fumigatus-specific IgG ≥27 mgA/L, or elevated serum (≥1.7) or bronchoalveolar lavage fluid (≥2.6) galactomannan); 2,15,16 (4) presence of progressive or persistent changes on chest computed tomography (CT) (one or more cavities, pulmonary fibrosis, fungal ball, pleural thickening, nodules and others); and (5) exclusion of pulmonary disorders with similar presentations (tuberculous and non-tuberculous mycobacterial infection, chronic necrotizing pneumonias, pulmonary malignancies and others, Figure 1).…”

Section: Casesmentioning

confidence: 99%

“…have updated these estimates to an annual incidence of >300,000 new cases and >40,000 deaths due to CPA‐PTLA in India alone 1 . At our centre, PTLA is the most prevalent underlying condition for developing CPA 4–6 …”

Section: Introductionmentioning

confidence: 99%

“…1 At our centre, PTLA is the most prevalent underlying condition for developing CPA. [4][5][6] CPA develops in up to 25% of patients with PTLA. [7][8][9] It remains to be seen why only a proportion of PTLA patients develop CPA despite similar environmental and pathogen-related factors.…”

mentioning

confidence: 99%

“…Subjects with CPA were more symptomatic than the diseased controls. The median (IQR) time following antituberculosis therapy (ATT) was 8(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) years in those with CPA and was significantly different from controls. All subjects with CPA…”

mentioning

confidence: 99%

See 2 more Smart Citations

Innate and adaptive immune responses in subjects with CPA secondary to post‐pulmonary tuberculosis lung abnormalities

Chirumamilla,

Arora,

Kaur

et al. 2024

Mycoses

Self Cite

View full text Add to dashboard Cite

BackgroundPost‐tuberculosis lung abnormality (PTLA) is the most common risk factor for chronic pulmonary aspergillosis (CPA), and 14%–25% of the subjects with PTLA develop CPA. The pathogenesis and the host immune response in subjects with PTLA who develop CPA need to be better understood.MethodsWe prospectively compared the innate and adaptive immune responses mounted by patients of PTLA with or without CPA (controls). We studied the neutrophil oxidative burst (by dihydrorhodamine 123 test), classic (serum C3 and C4 levels) and alternative (mannose‐binding lectin [MBL] protein levels) complement pathway, serum immunoglobulins (IgG, IgM and IgA), B and T lymphocytes and their subsets in subjects with PTLA with or without CPA.ResultsWe included 111 subjects (58 CPA and 53 controls) in the current study. The mean ± SD age of the study population was 42.6 ± 15.7 years. The cases and controls were matched for age, gender distribution and body weight. Subjects with CPA had impaired neutrophil oxidative burst, lower memory T lymphocytes and impaired Th‐1 immune response (lower Th‐1 lymphocytes) than controls. We found no significant difference between the two groups in the serum complement levels, MBL levels, B‐cell subsets and other T lymphocyte subsets.ConclusionSubjects with CPA secondary to PTLA have impaired neutrophil oxidative burst and a lower Th‐1 response than controls.

show abstract

Characterization of Treatment Response Outcomes in Chronic Pulmonary Aspergillosis: CPAnet Definitions Versus the Existing Criteria

Sehgal¹,

Arora²,

Cornely³

et al. 2023

Mycopathologia

View full text Add to dashboard Cite

Role of serum procalcitonin in the diagnosis and monitoring of treatment response in treatment-naïve subjects with chronic pulmonary aspergillosis

Cited by 4 publications

References 26 publications

Improved diagnostic markers for invasive pulmonary aspergillosis in COPD patients

Improved diagnostic markers for invasive pulmonary aspergillosis in COPD patients

Innate and adaptive immune responses in subjects with CPA secondary to post‐pulmonary tuberculosis lung abnormalities

Characterization of Treatment Response Outcomes in Chronic Pulmonary Aspergillosis: CPAnet Definitions Versus the Existing Criteria

Contact Info

Product

Resources

About