Role of serum melatonin and oxidative stress in childhood atopic dermatitis: A prospective study

Devadasan, Shanthy; Sarkar, Rashmi; Barman, Krishna Deb; Kaushik, Smita

doi:10.4103/idoj.idoj_77_20

Cited by 12 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, a study on 30 patients with AD aged 6 to 12 years and 30 healthy individuals evaluated serum levels of melatonin, SOD, and GPx and showed that melatonin levels were higher in AD group compared to the control group. However, it should be noted that the levels of GPx and SOD were also higher in AD cases, although the observed difference was not statistically significant [86].…”

Section: Melatoninmentioning

confidence: 69%

Antioxidant Agents for Treatment and Prevention of Patients with Atopic Dermatitis

Simoni¹,

Candelora²,

Belleggia³

et al. 2023

Preprint

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by itching, impaired epidermal barrier function and unbalanced inflammatory response. The pathophysiology involves immune dysregulation, with a predominance of T-helper 2 cells. AD is triggered by many known and unknown factors, including oxidative stress. Reactive oxygen species (ROS) contribute to AD pathogenesis by causing cellular damage and inflammation. Moreover, increased oxidative stress in AD leads to hyperactivation of the MAP kinase pathway, extracellular signal-regulated kinase (ERK) and p38, with DNA damage and subsequent skin barrier dysfunction. This narrative review provides a comprehensive overview of the role of natural antioxidant compounds, highlighting their potential therapeutic value in AD management. They include vitamin D, vitamin E, pyridoxine (vitamin B6), Vitamin C, carotenoids and melatonin, in AD. Despite some studies have shown an association between vitamin D, vitamin E, vitamin C and carotenoids levels and AD course, conflicting results exist. Pyridoxine supplementation has shown mixed results, and melatonin has demonstrated antioxidant and anti-inflammatory properties in AD; in fact, melatonin treatment resulted in a decrease in symptoms in patients with AD, although no significant correlation with changes in sleep latency was reported. In addition, iron and zinc (Zn) supplementation can also improve AD symptoms. Further research is needed to elucidate the optimal use of these natural antioxidants in AD treatment

show abstract

Section: Melatoninmentioning

confidence: 69%

Antioxidant Agents for Treatment and Prevention of Patients with Atopic Dermatitis

Simoni¹,

Candelora²,

Belleggia³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In children with AD and elevated levels of oxidant factors, a compensatory mechanism to counteract the action of oxidant products could be melatonin production. The mean serum melatonin levels in these patients were found to be higher, which could contribute to the reduction in skin inflammation [31]. Melatonin levels have also been studied in correlation with MDA.…”

Section: Role Of Oxidative Stress In Admentioning

confidence: 91%

An Overview on Atopic Dermatitis, Oxidative Stress, and Psychological Stress: Possible Role of Nutraceuticals as an Additional Therapeutic Strategy

Alessandrello,

Sanfilippo,

Minciullo

et al. 2024

IJMS

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a chronic inflammatory skin condition with a considerable impact on patients’ quality of life. Its etiology is multifactorial and, among the predisposing factors, a role is played by oxidative stress. Pollution, recurrent infections, and psychological stress contribute to oxidative stress, amplifying the production of proinflammatory cytokines and worsening barrier damage. There are various oxidative stress mechanisms involved in the pathogenesis of AD. Moreover, AD often appears to be associated with psychological disorders such as alexithymia, depression, and anxiety due to severe itching and related insomnia, as well as social distress and isolation. The increasing incidence of AD requires the evaluation of additional therapeutic approaches in order to reduce the psychological burden of this condition. Our review aims to evaluate the role of some nutraceuticals in AD treatment and its related psychological comorbidities. The combination of some natural compounds (flavonoids, alkaloids, terpenes, isothiocyanates) with traditional AD treatments might be useful in improving the effectiveness of therapy, by reducing chronic inflammation and preventing flare-ups, and in promoting corticosteroid sparing. In addition, some of these nutraceuticals also appear to have a role in the treatment of psychological disorders, although the underlying oxidative stress mechanisms are different from those already known for AD.

show abstract

Section: Antioxidant Agentsmentioning

confidence: 98%

Role of antioxidants supplementation in the treatment of atopic dermatitis: a critical narrative review

De Simoni,

Candelora,

Belleggia

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by itching, epidermal barrier dysfunction, and an unbalanced inflammatory reaction. AD pathophysiology involves a dysregulated immune response driven by T helper-2 cells. Many factors, including reactive oxygen species (ROS), are involved in AD pathogenesis by causing cellular damage and inflammation resulting in skin barrier dysfunction. This narrative review aims to provide a comprehensive overview of the role of natural molecules and antioxidant compounds, highlighting their potential therapeutic value in AD prevention and management. They include vitamin D, vitamin E, pyridoxine, Vitamin C, carotenoids, and melatonin. Some studies report a statistically significant association between antioxidant levels and improvement in AD, however, there are conflicting results in which antioxidant supplementation, especially Vitamin D, did not result in improvement in AD. Therefore, the clinical efficacy of these dietary nutritional factors in the treatment of AD needs to be further evaluated in clinical trials. Meanwhile, antioxidants can be incorporated into the management of AD patients in a personalized manner, tailored to the severity of the disease, comorbidities, and individual needs.

show abstract

Role of serum melatonin and oxidative stress in childhood atopic dermatitis: A prospective study

Cited by 12 publications

References 21 publications

Antioxidant Agents for Treatment and Prevention of Patients with Atopic Dermatitis

Antioxidant Agents for Treatment and Prevention of Patients with Atopic Dermatitis

An Overview on Atopic Dermatitis, Oxidative Stress, and Psychological Stress: Possible Role of Nutraceuticals as an Additional Therapeutic Strategy

Role of antioxidants supplementation in the treatment of atopic dermatitis: a critical narrative review

Contact Info

Product

Resources

About