Role of serum matrix metalloproteinase-2 and -9 to predict breast cancer progression

Patel, Suprava; Sumitra, G.; Koner, Bidhan Chandra; Saxena, Alpana

doi:10.1016/j.clinbiochem.2011.04.019

Cited by 91 publications

(80 citation statements)

References 27 publications

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“…Even though MMP-2 is weakly inducible, it is aberrantly up-regulated in the tumor microenvironment and serum concentration is, then, dramatically high (Colotti et al, 2007): this last aspect has been addressed for the MMP-2 screening as a relevant diagnostic and prognostic marker (Patel et al, 2011). Epidemiologic studies suggest MMP-2 quantification as prognostic marker in patients with colorectal cancer, ovarian cancer and thyroid cancer (Kwon et al, 2011;Rajoria et al, 2011).…”

Section: Biological Aspectsmentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

205

212

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a b s t r a c tHuman matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to their cellular compartmentalization and/or cellular type where they are expressed. An extensive review of the different MMPs structural and functional features is integrated with their pathological role in several types of diseases, spanning from cancer to cardiovascular diseases and to neurodegeneration. It emerges a very complex and crucial role played by these enzymes in many physiological and pathological processes.

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Section: Biological Aspectsmentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

205

212

View full text Add to dashboard Cite

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“…It has been reported that LCRMP-1 promotes the migration and invasion of NSCLC cells (8,9). In addition, increased expression of N-cadherin and MMPs following LCRMP-1 upregulation has confirmed that LCRMP-1 has a significant role in the migration, invasion and metastasis of tumor cells, as N-cadherin and MMPs are involved in epithelial-mesenchymal transition and remodelling of the extracellular matrix (19,20). In the present study, overexpression of LCRMP-1 was detected in OS cell lines.…”

Section: Discussionmentioning

confidence: 85%

Long form collapsin response mediator protein-1 promotes the migration and invasion of osteosarcoma cells

et al. 2016

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Abstract. It has been reported that long form collapsin response mediator protein-1 (LCRMP-1) promotes the metastasis of non-small cell lung cancer. Osteosarcoma (OS) is a human cancer with a high potential for metastasis. The present study aimed to investigate the role of LCRMP-1 in OS metastasis. The expression of LCRMP-1 in OS specimens and cell lines was evaluated using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. Furthermore, the migration and invasion of OS cells with LCRMP-1-knockdown was investigated to examine the role of LCRMP-1 in OS metastasis. In addition, the expression of N-cadherin and matrix metalloproteinases (MMPs), which are involved in cell migration, was evaluated using RT-qPCR. Increased expression of LCRMP-1 was observed in the OS tissues and cell lines, accompanied by the enhanced migration and invasion of the OS cells. LCRMP-1-knockdown resulted in a significant decrease in the expression of N-cadherin and MMPs, as well as inhibition of the migration and invasion of the OS cells. Overexpression of LCRMP-1 promoted OS metastasis. Therefore, LCRMP-1 may be a promising target for the effective treatment of OS.

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“…Each method has its own application characteristics. Immunoassay, such as ELISA kit method, is sensitive and specific, but it requires costly antibody proteins and tedious separation/washing operations [17]. Gel electrophoresis-based zymography is suitable for qualitative but not for quantitative determination [18].…”

Section: Traditional Detection Methods Of Mmpsmentioning

confidence: 99%

Noninvasive Detection and Imaging of Matrix Metalloproteinases for Cancer Diagnosis

et al. 2017

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Role of serum matrix metalloproteinase-2 and -9 to predict breast cancer progression

Cited by 91 publications

References 27 publications

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Long form collapsin response mediator protein-1 promotes the migration and invasion of osteosarcoma cells

Noninvasive Detection and Imaging of Matrix Metalloproteinases for Cancer Diagnosis

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