Role of serum levels of intraoperative brain natriuretic peptide for predicting acute kidney injury in living donor liver transplantation

Chae, Min Suk; Park, Hyunjoon; Choi, Ho Joong; Park, Misun; Chung, Hyun Sik; Hong, Sang Hyun; Park, Chul Soo; Choi, Jong Ho; Lee, Hyung Mook

doi:10.1371/journal.pone.0209164

Cited by 6 publications

(13 citation statements)

References 48 publications

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“…However, we adopted the 2012 KIDIGO definition of AKI in our study, which is still based on increases in serum creatinine concentrations. New biomarkers of kidney injury, such as serum cystatin C (ScysC) Neutrophil Gelatinase-Associated Lipocalin (NGAL) and brain natriuretic peptide (BNP) may facilitate earlier detection of renal injury, and thus early intervention aimed at limiting the associated morbidity and mortality [ 18 – 20 ].…”

Section: Discussionmentioning

confidence: 99%

Postoperative anemia is a risk factor for acute kidney injury after open aorta and vena cava surgeries

Cui

Shao

et al. 2020

PLoS ONE

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Open aorta and vena cava surgeries are usually associated with substantial blood loss which may result in postoperative acute kidney injury (AKI). The present study is designed to investigate the prevalence, outcome and risk factors of postoperative AKI associated with open aorta and vena cava surgeries, with a focus on the role of anemia in these conditions. A retrospective review of medical records of Peking Union Medical College Hospital was conducted. Patients who underwent open aorta and vena cava surgeries during January 1, 2010 and June 30, 2014 were included in this study. The primary analysis was between patients underwent open aorta and vena cava surgeryies, with or without postoperative AKI. Multivariable logistic regression models were used to determine risk factors of postoperative AKI. The study included 79 patients (63.3% male) with a mean age of 52.5±17.3 years (range, 17-81 years). Postoperative AKI occurred in 23/79 (29.1%) of the patients. Anemia was present in 11/79 (16%) at baseline, and increased to 45/79 (52%) postoperatively. After adjustment for various risk factors, postoperative anemia (OR, 5.202; 95% CI 1.403-19.285) was independently associated with postoperative AKI. AKI is a common complication in patients who undergo open aorta and vena cava surgeries, and postoperative anemia was the most relevant predictive factor of AKI. Strategies to minimize bleeding and anemia for all patients may be advisable. Further studies are needed to assess the impact of AKI on long term outcome and to examine preventive strategies to address potentially modifiable risk factors.

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Section: Discussionmentioning

confidence: 99%

Postoperative anemia is a risk factor for acute kidney injury after open aorta and vena cava surgeries

Cui

Shao

et al. 2020

PLoS ONE

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“…Furthermore, a close correlation between serum levels of BNP and diastolic parameters on echocardiography, such as tissue Doppler imaging, is present so that high serum levels of BNP (> 100 pg/mL) are reflected by increased left ventricular filling pressure [38,39]. In previous LT studies, high serum levels of BNP were significantly associated with poor postoperative outcomes, such as graft dysfunction, kidney injury, and patient survival [24,29,40]. In our study, patients with normal diastolic function experienced a significant decrease in the proportion of high BNP level (> 100 pg/mL) through the surgical phases; however, this finding was not evident in the patients with diastolic dysfunction according to both recommendations.…”

Section: Discussionmentioning

confidence: 99%

“…According to our hospital LDLT protocol that was described previously in detail [24,25], the piggyback surgical procedure was applied using the right lobe from the living donor that was larger than 40% of the recipient’s standard liver volume or 0.8% of the recipient’s body weight [26]. After completing the hepatic vascular anastomosis, intact hepatic circulation was demonstrated using Doppler ultrasonography.…”

Section: Methodsmentioning

confidence: 99%

“…Intraoperative BNP levels were evaluated three times, such as in the preanhepatic phase (i.e., immediately after inducing anesthesia); in the anhepatic phase (i.e., starting at the portal venous anastomosis); and in the neohepatic phase (i.e., starting at peritoneal closure) [24,29]. BNP levels were investigated via enzyme-linked immunosorbent assay using a Siemens ADVIA Centaur (Siemens Healthcare Diagnostics, Erlangen, Germany).…”

Section: Methodsmentioning

confidence: 99%

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The 2016 ASE/EACVI recommendations may be able to more accurately identify patients at risk for diastolic dysfunction in living donor liver transplantation

et al. 2019

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Background The aim of this study was to compare the prevalence of diastolic dysfunction between the 2016 American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging and 2009 ASE/European Association of Echocardiography recommendations in patients undergoing living-donor liver transplantation (LDLT). Patients and methods A total of 312 adult patients who underwent LDLT at our hospital from January 2010 to December 2017 were retrospectively analyzed. Exclusion criteria were systolic dysfunction, arrhythmia, myocardial ischemia, and mitral or aortic valvular insufficiency. Results The study population was largely male (68.3%), and the median age was 54 (49–59) years. The median model for end-stage liver disease score was 12 (6–22) points. A predominant difference in the prevalence rates of diastolic dysfunction was observed between the two recommendations. The prevalence rates of diastolic dysfunction and indeterminate diastolic function were lower according to the 2016 recommendations than the 2009 recommendations. The level of concordance between the two recommendations was poor. The proportion of patients with a high brain natriuretic peptide level (> 100 pg/mL) decreased significantly during surgery in the normal and indeterminate groups according to the 2009 recommendations; however, only the normal group showed an intraoperative decrease in the proportion according to the 2016 recommendations. Patients with diastolic dysfunction showed a poorer overall-survival rate than those with normal function according to both recommendations. However, there was a difference in the survival rate in the indeterminate group between the two recommendations. A significant difference in patient survival rate was observed between the dysfunction and indeterminate groups according to the 2009 recommendations; however, the difference was not significant in the 2016 recommendations. Conclusions The 2016 classification may be better able to identify patients with a risk for diastolic dysfunction. Particularly, patients in the 2016 indeterminate group seemed to require a cardiac diastolic functional evaluation more frequently during and after surgery than those in the 2009 indeterminate group.

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“…Previous studies have found elevated concentrations of B-type natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with ACS and have a prognostic value in patients with ACS [ 18 , 19 ]. Moreover, some studies have found that levels of BNP or NT-proBNP are higher in patients with AKI [ 20 – 22 ], especially for those who are diagnosed with ACS and undergo coronary angiography or PCI [ 23 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

Brain Natriuretic Peptide for Predicting Contrast-Induced Acute Kidney Injury in Patients with Acute Coronary Syndrome Undergoing Coronary Angiography: A Systematic Review and Meta-Analysis

Liu

Mao

et al. 2020

Journal of Interventional Cardiology

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Objective. To assess the diagnostic value of B-type natriuretic peptide (BNP) or N-terminal pro-B-type natriuretic peptide (NT-proBNP) for contrast-induced acute kidney injury (CI-AKI) in patients with acute coronary syndrome (ACS) undergoing coronary angiography. Background. ACS remains a major cause of death worldwide. Patients with ACS undergoing coronary angiography are more likely to develop CI-AKI, which correlates highly with poor clinical outcomes. Early diagnosis of CI-AKI remains a challenge. Many recent studies have suggested that BNP or NT-proBNP may be a useful biomarker for the early diagnosis of CI-AKI. Methods. We searched databases (PubMed, EMBASE, and Cochrane Library) to identify eligible studies. Two authors independently screened the studies and extracted data. We used the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) criteria to assess the methodological quality of the included studies and STATA to perform all statistical analyses. Results. Nine studies including 2832 patients were identified. The pooled sensitivity of 0.73 (95% CI 0.65–0.79), specificity of 0.79 (95% CI 0.70–0.85), and area under the summary receiver operating characteristic curve of 0.81 (95% CI 0.77–0.84) suggested that BNP or NT-proBNP had a good diagnostic value for CI-AKI in patients with ACS undergoing coronary angiography. Conclusions. Our findings suggest that BNP or NT-proBNP may be an effective predictive marker for CI-AKI. However, additional high-quality studies are required to find the optimal cutoff value and the diagnostic value of BNP or NT-proBNP in combination with other biomarkers.

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Role of serum levels of intraoperative brain natriuretic peptide for predicting acute kidney injury in living donor liver transplantation

Cited by 6 publications

References 48 publications

Postoperative anemia is a risk factor for acute kidney injury after open aorta and vena cava surgeries

Postoperative anemia is a risk factor for acute kidney injury after open aorta and vena cava surgeries

The 2016 ASE/EACVI recommendations may be able to more accurately identify patients at risk for diastolic dysfunction in living donor liver transplantation

Brain Natriuretic Peptide for Predicting Contrast-Induced Acute Kidney Injury in Patients with Acute Coronary Syndrome Undergoing Coronary Angiography: A Systematic Review and Meta-Analysis

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