Role of Serotonin in Systemic Impairment of Motor Function of the Digestive Tract

Lychkova, A. E.

doi:10.1007/s10517-009-0519-x

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Several research studies involving patients with musculoskeletal pain have examined the correlation between these two nosological entities, although more focus has been given to the central nervous system structures involved in pain perception and colonic stimulation [39]. There is no scientific evidence to explain the frequent occurrence of this nosological entity in patients with myofascial pain, although several studies have indicated the occurrence of constipation in patients with musculoskeletal pain [11,40,41]. However, to establish constipation in our study we employed a method subjective evaluation tool (Roma III), but internationally validated and recognized for considering the effort to defecate, frequency and consistency (shape) of feces, classified by Bristol Fecal Shape Scale (EBFF) [34].…”

Section: Discussionmentioning

confidence: 99%

Constipation in patients with myofascial pain syndrome as important aspect for clinical and nutritional treatment: A case-control study

et al. 2017

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A B S T R A C T ObjectiveTo identify the occurrence of constipation in patients with myofascial pain syndrome and to correlate these disorders with the clinical and nutritional variables. MethodsThis report describes a case-control study performed with 98 adults of both sexs, including 49 patients and 49 individuals without pain. The intensity of the reported pain was evaluated using the Pain Visual Analog Scale, which provided a simple and efficient measurement of pain intensity consisting of a 10cm horizontal line with Revista de NutriçãoRev. Nutri., Campinas, 30(5):567-581, set./out., 2017 https://doi.org/10.1590/1678-98652017000500003 568 JA BARROS-NETO et al.the ends marked "absence of pain" and "worst possible pain". The occurrence of constipation was evaluated using the Rome III criteria. A multivariate linear regression was proposed to investigate risk factors between the frequency of bowel movements per week and independent variables this study. ResultsThe mean ages of the patients and controls were 45.9 (7.6) years and 41.2 (12.2) years, respectively. The intensity of the reported pain showed a mean of 7.3 (1.6) points. The likelihood of exhibiting constipation was 4.5 times higher in the patients than in the controls (p=0.001). The number of stools per week was negatively correlated with the intensity of the reported pain (r=-0.613, p<0.001). The use of benzodiazepines was negatively correlated with the frequency of bowel movements per week, while the use of muscle relaxants appeared to increase the frequency of defecation when combined with the use of benzodiazepines and adjusted for the intake of fiber, water and sexs (p=0.037). ConclusionConstipation was a frequent nosological entity in this patient population and the persistence of a change in intestinal motility showed a significant correlation with the pain intensity and low water intake. The reduction of the number of stools per week seems to be associated with the use of benzodiazepines.Keywords: Chronic pain. Constipation. Myofascial pain syndromes. (r=-0,613, p<0,001 R E S U M O Objetivo Identificar a ocorrência de constipação em pacientes com síndrome dolorosa miofascial e correlacionar essa desordem da motilidade intestinal com variáveis clínicas e nutricionais. Métodos Trata-se de um estudo de caso-controle, realizado com 98 indivíduos adultos de ambos os sexos I N T R O D U C T I O NChronic pain is considered a serious and growing public health problem worldwide. Affected people require medical attention approximately five times more frequently than the rest of the population. These patients have impaired physical, mental and social wellbeing, resulting in disability and work absenteeism [1,2].Myofascial Pain Syndrome (MPS) is characterized by regional chronic muscle pain located in a single muscle or in muscle groups.Revista de Nutrição Rev. Nutri., Campinas, 30(5):567-581, set./out., 2017 CONSTIPATION IN PATIENTS WITH MYOFASCIAL PAIN SYNDROME 569

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Section: Discussionmentioning

confidence: 99%

Constipation in patients with myofascial pain syndrome as important aspect for clinical and nutritional treatment: A case-control study

et al. 2017

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“…Outro importante neurotransmissor associado ao processo de transmissão dolorosa é a serotonina (5-HT), amina biogênica que tem sua taxa de síntese dependente da disponibilidade de triptofano livre no plasma. A 5-HT é secretada por diversos neurônios no núcleo da rafe e atua como inibidora das vias de transmissão dolorosa na medula, estando relacionada com as alterações de comportamento, de humor, ansiedade, depressão, sono, fadiga, supressão do apetite, além de estar envolvida na regulação da motilidade do trato gastrointestinal (CAMILLERI, 2006;LYCHKOVA, 2009;RAIMUNDO et al, 2009). Estudos in vivo revelaram que alterações no metabolismo da 5-HT, com a diminuição na sua síntese e liberação, implicam na redução da atividade do sistema inibidor de dor, com uma consequente elevação da resposta dolorosa a estímulos algogênicos (LYCHKOVA, 2009;RAIMUNDO et al, 2009).…”

Section: A Nocicepção Dolorosaunclassified

“…A 5-HT é secretada por diversos neurônios no núcleo da rafe e atua como inibidora das vias de transmissão dolorosa na medula, estando relacionada com as alterações de comportamento, de humor, ansiedade, depressão, sono, fadiga, supressão do apetite, além de estar envolvida na regulação da motilidade do trato gastrointestinal (CAMILLERI, 2006;LYCHKOVA, 2009;RAIMUNDO et al, 2009). Estudos in vivo revelaram que alterações no metabolismo da 5-HT, com a diminuição na sua síntese e liberação, implicam na redução da atividade do sistema inibidor de dor, com uma consequente elevação da resposta dolorosa a estímulos algogênicos (LYCHKOVA, 2009;RAIMUNDO et al, 2009). Evidências científicas provenientes de estudos em modelos animais demonstraram que as citocinas poderiam induzir a dor por diversos mecanismos.…”

Section: A Nocicepção Dolorosaunclassified

Comprometimento da integridade intestinal na fibromialgia e sindrome dolorosa miofascial: uma revisão

Neto¹,

Machado²,

Kraychete³

et al. 2011

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Fibromialgia e dor crônica miofascial são condições muito frequentes na clínica da dor e podem representar uma das maiores causas de sofrimento humano. A fisiopatologia dessas doenças vem sendo relacionada com a presença de substâncias proinflamatórias produzidas em resposta a mecanismos estressores. Diversos fatores têm sido comumente encontrados em associação a presença dessas síndromes dolorosas, entre eles, alterações e comprometimento da integridade intestinal tem sido frequentemente relatados. O presente estudo teve como meta revisar artigos publicados em periódicos nacionais e internacionais de 2001 a 2011, cujos objetivos foram avaliar o comprometimento da integridade intestinal e as dores crônicas musculoesqueléticas do tipo fibromialgia e dor crônica miofascial, enfatizando a síntese e liberação das citocinas proinflamatórias nessas situações clínicas.

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Role of Serotonin in Systemic Impairment of Motor Function of the Digestive Tract

Cited by 2 publications

References 6 publications

Constipation in patients with myofascial pain syndrome as important aspect for clinical and nutritional treatment: A case-control study

Constipation in patients with myofascial pain syndrome as important aspect for clinical and nutritional treatment: A case-control study

Comprometimento da integridade intestinal na fibromialgia e sindrome dolorosa miofascial: uma revisão

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