Role of serotonin and noradrenaline in the acute itch processing in mice

Miyahara, Yu; Funahashi, Hideki; Naono-Nakayama, Rumi; Haruta-Tsukamoto, Ayaka; Nishimori, Toshikazu; Ishida, Yoshiteru

doi:10.1016/j.ejphar.2019.02.013

Cited by 13 publications

(7 citation statements)

References 35 publications

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“…Historically, the noradrenergic and serotonergic pathways were known to alleviate thermal, mechanical, and neuropathic pain in animal models ( 32 ). However, recent research has indicated their involvement in acute ( 35 ) and chronic itch ( 36 ). A study by Koga et al ( 37 ) suggested that descending noradrenergic signalling inhibits acute and chronic itch, supporting our findings that yohimbine, an α1/α2 receptor antagonist, suppressed the anti-alloknesis activity of antipruritics.…”

Section: Discussionmentioning

confidence: 99%

Model of Chronic Itch in Aged Mice: Beneficial Effects of Drugs Affecting Descending Modulatory Systems

Kojima,

Komiya,

Honda

et al. 2024

Acta Derm Venereol

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Pruritus in the elderly, particularly those cases without skin dryness or other identifiable causes, makes treatment challenging due to the lack of evidence regarding the therapeutic effects of antipruritics. This study proposes an age-related alloknesis mouse model for an evaluation system for such cases, and aimed to investigate the effectiveness and mechanisms of action of several drugs commonly used as antipruritics in Japan, utilizing this model. Mice 69–80 weeks old were used as aged mice, and the level of mechanical alloknesis was counted as the number of scratching behaviours in response to innocuous stimuli. Bepotastine, neurotropin, pregabalin, baricitinib, and abrocitinib were used as antipruritics, and yohimbine and methysergide as inhibitors of the descending inhibitory pathway. The findings suggest that mechanical alloknesis in aged mice is a suitable animal model for assessing pruritus in the elderly without xerosis, and pregabalin, neurotropin, baricitinib, and abrocitinib may be effective antipruritics in the elderly through activating both the noradrenergic and serotonergic descending inhibitory pathways. These findings may be useful for the selection of antipruritics for pruritus in the elderly without skin lesions or dryness.

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Section: Discussionmentioning

confidence: 99%

Model of Chronic Itch in Aged Mice: Beneficial Effects of Drugs Affecting Descending Modulatory Systems

Kojima,

Komiya,

Honda

et al. 2024

Acta Derm Venereol

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“…Since venlafaxine is an SNRI that exerts antipruritic effects, serotonin and noradrenaline receptors appear to be involved in the pruritic process. 16 …”

Section: Discussionmentioning

confidence: 99%

“…Since venlafaxine is an SNRI that exerts antipruritic effects, serotonin and noradrenaline receptors appear to be involved in the pruritic process. 16 Venlafaxine exerted antidepressant, antinociceptive, and antipruritic effects in a patient with depression, migraine and chronic pruritus; however, the relationship between the onset times of these effects has not yet been elucidated. In our patient, the treatment with venlafaxine exerted antipruritic effects before the amelioration of migraine and depressive symptoms, indicating that the onset time of antipruritic effects after the treatment with venlafaxine was faster than those of antinociceptive and antidepressant effects.…”

Section: Discussionmentioning

confidence: 99%

Time course of effects of venlafaxine on migraine and generalized pruritus in a patient with depression

Miyahara

Funahashi

Haruta-Tsukamoto

et al. 2021

Clinical Case Reports

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“…The administration of 5-HT produces membrane hyperpolarization in about 50% of dorsal horn neurons, while NE hyperpolarizes more than 80% of them, suggesting the need to augment both NE and 5-HT concentrations in order to suppress algesia. Neither atomoxetine (selective noradrenaline reuptake inhibitor) nor an SSRI alone have such a marked effect ( Miyahara et al, 2019 ).…”

Section: Pain: a Simplified Modelmentioning

confidence: 99%

Neuropathic pain: Mechanisms and therapeutic strategies

Petroianu

Aloum

Adem

2023

Front. Cell Dev. Biol.

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The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The number of pharmacodynamically distinct and clinically available medications is low and the successes achieved modest. Pain Medicine practitioners are confronted with the ethical dichotomy imposed by Hippocrates: On one hand the mandate of primum non nocere, on the other hand, the promise of heavenly joys if successful divinum est opus sedare dolorem. We briefly summarize the concepts associated with nociceptive pain from nociceptive input (afferents from periphery), modulatory output [descending noradrenergic (NE) and serotoninergic (5-HT) fibers] to local control. The local control is comprised of the “inflammatory soup” at the site of pain origin and synaptic relay stations, with an ATP-rich environment promoting inflammation and nociception while an adenosine-rich environment having the opposite effect. Subsequently, we address the transition from nociceptor pain to neuropathic pain (independent of nociceptor activation) and the process of sensitization and pain chronification (transient pain progressing into persistent pain). Having sketched a model of pain perception and processing we attempt to identify the sites and modes of action of clinically available drugs used in chronic pain treatment, focusing on adjuvant (co-analgesic) medication.

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Role of serotonin and noradrenaline in the acute itch processing in mice

Cited by 13 publications

References 35 publications

Model of Chronic Itch in Aged Mice: Beneficial Effects of Drugs Affecting Descending Modulatory Systems

Model of Chronic Itch in Aged Mice: Beneficial Effects of Drugs Affecting Descending Modulatory Systems

Time course of effects of venlafaxine on migraine and generalized pruritus in a patient with depression

Neuropathic pain: Mechanisms and therapeutic strategies

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