Role of SDF-1/CXCR4 system in survival and migration of bone marrow stromal cells after transplantation into mice cerebral infarct

Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion

“…Thus, knockdown of Cxcr4 in BMSCs not only blocked the migration of BMSCs to DRGs, but also shortened the duration of BMSC-induced analgesia. This is consistent with a previous report that BMSCs from Cxcr4-KO mice exhibited reduced migration to the brain subjected to permanent middle cerebral artery occlusion and impaired functional recovery (47). It is noteworthy that we observed many BMSCs in lumbar DRGs even 8 weeks after injection of BMSCs into CCI mice.…”

“…Interestingly, CXCL12 (also named SDF-1) and its receptor CXCR4 were not only involved in neuropathic pain (46), but were also implicated in BMSC trafficking (47). CCI caused a marked increase in CXCL12 levels in L4-L6 DRGs compared with those in sham control mice ( Figure 8B).…”

Mesenchymal stem cells as a treatment for neonatal ischemic brain damage

“…In response to HI brain injury, stromal cell-derived factor-1α expression is upregulated near the lesion site and expressed for at least 14 d after induction of the injury (36). MSCs that express CXCR4 migrate to the lesioned area in the brain after intravenous transplantation, whereas MSCs derived from CXCR4 knockout mice do not migrate to the lesion (37). Furthermore, in response to in vitro culturing of MSCs with ischemic brain extract, MSCs increase the expression of CXCR4 on their membrane (32) and could thereby increase their migration toward the lesion site.…”

Mesenchymal Stem Cells: A Future Option for Intervening Disease Management

“…The mechanism through which the MSC-mediated tissue regeneration may vary from type of injury or tissues involved. For an instance, the increased expression of stromal cell-derived factor 1 (SDF-1) at the site of injury can attract the MSCs to the injured tissue [63,64]. The expression of C-X-C chemokine receptor type 4 (CXCR4) by MSCs regulates the adhesion of MSCs to endothelial cells.…”

“…This has been shown to be a critical step for MSCs to migrate to the target tissue. Thus, the expression of the CD184 (Fusin) is important to expedite the interaction between SDF-1 and CXCR4 system, which play an important role in the survival and migration of bone marrow stromal cells after transplantation into mice cerebral infarct [64]. MSCs can enhance the angiogenesis at the injured tissue, where the level of TGF-β1 is dramatically increased.…”