Role of saliva in the caries experience and calculus formation of young patients undergoing hemodialysis

Andrade, Márcia Rejane Thomas Canabarro; Salazar, Sabrina Loren A.; Sá, Leandro Figueira Reis de; Portela, Maristela Barbosa; Ferreira‐Pereira, Antônio; Soares, R. Félix; Leão, Anna Thereza Thomé; Primo, Laura Guimarães

doi:10.1007/s00784-015-1441-4

Cited by 25 publications

(46 citation statements)

References 37 publications

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“…As stated previously, prophylactic antibiotic therapy is therefore indicated for transplant patients before invasive dental procedures are performed. 45 Moreover, prolonged corticosteroid therapy may necessitate the administration of a supplementary dose in stressful situations, for example, during dental procedures, to prevent an adrenal crisis. The most recent guidelines recommend a dose of 25 mg of hydrocortisone via the intravenous route prior to an intervention.…”

Section: Dental Protocols In Uremic Patientsmentioning

confidence: 99%

Oral manifestations in chronic uremia patients

et al. 2015

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The incidence of chronic renal failure (CRF) is approximately 200 cases per million people in different Western countries. Recent data indicate that the incidences of these pathologies are increasing. Ninety percent of patients with CRF report oral signs and symptoms that affect both the bone and soft tissues. A broad range of lesions may be observed in chronic uratemia patients, including the following: gingival hyperplasia, enamel hypoplasia, petechiae, gingival bleeding, and others lesions. These patients require various types of treatment ranging from dietary and lifestyle changes to dialysis and kidney transplantation. CRF often leads to multiple oral manifestations that are difficult for dentists to manage. The present study examined the characteristics of this disease, the existing therapeutic options and the relevant considerations for dental professionals.

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Section: Dental Protocols In Uremic Patientsmentioning

confidence: 99%

Oral manifestations in chronic uremia patients

et al. 2015

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“…Due to the multi-stage character of the ion exchange, the mineral groups and complexes (phosphates) should be retained for a long time within the oral cavity and should be in contact with the dental enamel [1,6,[48][49][50]. As shown, this could be realised only under an endogenous supply of the ions [34,35,51].…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that excessive levels of calcium and phosphates in mixed saliva result in a rapid deposition of calcium phosphates in the form of mineral phases on the surface of enamel, which hinders normal remineralisation [6]. A short-term increase in the concentration over the standard values stipulates the deposition and formation of foreign calcium phosphates resulting in the limited permeability of substances through the biofilm, the origin of dental deposit, and enhanced enamel solubility.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, there is no information in literature regarding the comparative analysis of changes in the mixed saliva molecular composition when using different caries preventive drugs since this issue requires an interdisciplinary approach. The significance of this information for explaining the processes proceeding at the tentative boundary between plaque fluid and mixed saliva is indisputable, as confirmed by a number of investigations [6,8,29,30]. Therefore, the aim of this study is to investigate the changes in the molecular composition of human mixed saliva with the use of endogenous and exogenous methods for caries prevention and to determine the duration of these changes in relation to the initial state of the oral fluid.…”

Section: +mentioning

confidence: 91%

“…The significance of the changes in the molecular composition of mixed saliva has been previously shown in diabetes, oncology and pathologies of the oral cavity [4][5][6][7][8][9]. Considerable deviation of the molecular composition in the oral fluid can have an influence on the content of mineral complexes in plaque fluid and thus, impact on the process of enamel remineralisation [1,[10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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Does dentifrice provide the necessary saturation of ions in oral fluids to favour remineralisation?

Seredin¹,

Goloshchapov²,

Yuri³

et al. 2018

Russ Open Med J

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Background -Changes in the molecular composition of mixed human saliva using endogenous and exogenous methods of caries prevention were studied and the duration of these changes in relation to the initial state of the oral fluid was determined. Material and Methods -In total, 200 European healthy, addiction-free, university-educated males and females, aged 22-30 were recruited for the study. Participants collected their mixed saliva samples after the use of a multi-mineral toothpaste (exogenous prevention) and after three days of taking a calcium glycerophosphate tablet (endogenous prevention). In the first stage of the study, samples of mixed saliva were analysed by infrared (IR) lab spectrometer and equipment of infrared microspectroscopy beamline at the Australian Synchrotron (Victoria, Australia) was used in the second stage of study. Results -Based on the experimental data obtained by IR-spectroscopy technique, the mineral/organic and carbon/phosphate ratios were calculated. The changes in the organic mineral balance of the oral cavity induced by these two preventive methods were analysed. The statistical significance of the results for the confidence level of p is indicated. The data shows that changes in the molecular composition of mixed saliva when using an exogenous method of caries prevention only provides a short-term effect, continuing for the first 30 minutes after the preceding prevention. Moreover, calcium glycerophosphate tablets can change the organic-mineral balance in mixed saliva, increasing the content of mineral groups and complexes. The content of endogenous, biologically accessible phosphate groups and complexes in the mixed saliva exceeds by approximately 12% that of the mixed saliva before the use of the prevention agents. Conclusion -Use of calcium glycerophosphate tablets in combination with brushing (a combination of endogenous and exogenous prevention methods) leads to the long-term presence of high concentrations of ions, mineral complexes and groups (phosphates) in the oral fluid.

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