2017
DOI: 10.4149/gpb_2017031
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Role of S-adenosylmethionine cycle in carcinogenesis

Abstract: Abstract. Alterations in enzymatic activities underlying the cellular capacity to maintain functional S-adenosylmethionine (SAM) cycle are associated with modified levels of its constituents. Since SAM is the most prominent donor of methyl group for sustaining the methylation pattern of macromolecules by methyltransferases, its availability is an essential prerequisite for sustaining the methylation pattern of nucleic acids and proteins. In addition, increased intracellular concentrations of S-adenosylhomocyst… Show more

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Cited by 20 publications
(14 citation statements)
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“…SAM is also metabolized through the methionine salvage pathway, wherein SAM is first decarboxylated and then recycled with the by guest on October 30, 2020 http://www.jbc.org/ Downloaded from release of methionine, adenosine and polyamines (29). In the deregulated MTHFR mutant, we observed a 2.5 fold increase in the amount of spermine suggesting that the pathway is indeed active in the mutant.This possibly also explains why arginine, which is a precursor for spermine, is also observed at significantly lower levels in the deregulated mutant.…”
Section: Discussionmentioning
confidence: 70%
“…SAM is also metabolized through the methionine salvage pathway, wherein SAM is first decarboxylated and then recycled with the by guest on October 30, 2020 http://www.jbc.org/ Downloaded from release of methionine, adenosine and polyamines (29). In the deregulated MTHFR mutant, we observed a 2.5 fold increase in the amount of spermine suggesting that the pathway is indeed active in the mutant.This possibly also explains why arginine, which is a precursor for spermine, is also observed at significantly lower levels in the deregulated mutant.…”
Section: Discussionmentioning
confidence: 70%
“…MAT1A belongs to a family of methyltransferases that contribute to methylation of a variety of molecules including DNA and histones, via synthesis of SAM [18]. In cancer research, MAT1A has been mostly described in the context of hepatocellular carcinoma (HCC), where it was previously shown that a switch in gene expression from MAT1A to MAT2A (M1-M2 switch) promoted cancer invasion and metastasis.…”
Section: Discussionmentioning
confidence: 99%
“…The high extracellular ATP concentration characteristic of neoplastic cells is also related to the elevated presence of exADO, according to the expression and activity of various ectonucleotidases. In this context, the nucleoside ADO has been recognized as a pro-tumoral factor [128]. For example, in non-small cell cancer tissues and cancer-associated fibroblast, antagonists for A2AR (ZM241385 and SCH5826) inhibited cellular proliferation and the human tumor xenograft in mice [129].…”
Section: Warburg Effect and Purinergic Signalingmentioning
confidence: 99%