Role of RpoS in Regulating Stationary Phase Salmonella Typhimurium Pathogenesis-Related Stress Responses under Physiological Low Fluid Shear Force Conditions

Abstract

Bacterial pathogens respond dynamically to a variety of stresses in the infected host, including physical forces of fluid flow (fluid shear) across their surfaces. While pathogens experience wide fluctuations in fluid shear during infection, little is known about how these forces regulate microbial pathogenesis.

Antibiofilm mechanism of peppermint essential oil to avert biofilm developed by foodborne and food spoilage pathogens on food contact surfaces

“…Pfs expression is required for several metabolic pathways and limits the production of autoinducer‐2, a molecule proposed to play a central role in interspecies quorum sensing (Kim et al., 2006), and CsgA is an essential protein for the development of the rdar phenotype, biofilm formation, and cell invasion in E. coli (Uhlich et al., 2009). In Salmonella , RpoS is the master regulator of the general stationary‐phase stress response and protects the bacteria against a variety of harmful conditions encountered both in the infected host and the environment (Meléndez et al., 2022). The hilA gene encodes an OmpR/ToxR family transcriptional regulator that activates the expression of invasion genes in response to both environmental and genetic regulatory factors (Boddicker et al., 2003).…”