Role of RIN1 on telomerase activity driven by EGF-Ras mediated signaling in breast cancer

Zhang, W.; Veisaga, Maria‐Luisa; Barbieri, M. Alejandro

doi:10.1016/j.yexcr.2020.112318

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…RIN1 plays a crucial role in the proliferative response to epidermal growth factors (EGF). Low levels of RIN1 are associated with impaired cell proliferation in response to EGF [ 21 ]. The activation of Rab5 by RIN1 is therefore important in the control of the signaling pathway of EGFR.…”

Section: Discussionmentioning

confidence: 99%

Expression of RAS and RAB interactor 1 (RIN1) in head and neck tumors at selected hospital in Ghana

Osei Saahene,

Barnes,

Yeboah

et al. 2024

PLoS ONE

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Background Head and neck tumors (HNT) are tumors of the paranasal sinuses, the salivary glands and the upper aerodigestive tract. RIN1 is a Ras effector protein regulating epithelial cell properties and has been implicated in a number of cancers. Method The aim of this study was to investigate the expression of RIN1 in head and neck tumors. RIN1 expression was assessed using quantitative real-time PCR (qRT-PCR) and immunohistochemical staining on archival head and neck tissue samples between 2014 and 2020. Results RIN1 expression was low in tissue samples as compared with the normal head and neck tissues. High and low RIN1 levels were compared with ages ≤40, >40 in the head and neck tumors of p-value 0.02. There was a significant difference with p-values of 0.001 when poor and well-moderate malignant tumors were compared. Conclusion Our data suggests that RIN1may play an important role in head and neck tumor progression and that its expression may provide baseline data to facilitate identification of new molecular targeted therapeutics.

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Section: Discussionmentioning

confidence: 99%

Expression of RAS and RAB interactor 1 (RIN1) in head and neck tumors at selected hospital in Ghana

Osei Saahene,

Barnes,

Yeboah

et al. 2024

PLoS ONE

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“…In addition, c-MYC is an important target for STAT3 to exert oncogenic effects [ 81 ]. In MDA-MB-231 cells, RIN1 has been shown to inhibit hTERT expression, potentially attributable to the downregulation of c-MYC, Ets2, and STAT3 activities [ 82 ]. In MCF-7 cells, leptin enhances the interaction between STAT3 and the hTERT promoter, thereby resulting in the upregulation of hTERT transcription [ 83 ].…”

Section: Htert Regulation Mechanism In Breast Cancermentioning

confidence: 99%

Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer

Yang,

Han,

Guan

et al. 2023

Cell Commun Signal

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Telomerase reverse transcriptase (TERT/hTERT) serves as the pivotal catalytic subunit of telomerase, a crucial enzyme responsible for telomere maintenance and human genome stability. The high activation of hTERT, observed in over 90% of tumors, plays a significant role in tumor initiation and progression. An in-depth exploration of hTERT activation mechanisms in cancer holds promise for advancing our understanding of the disease and developing more effective treatment strategies. In breast cancer, the expression of hTERT is regulated by epigenetic, transcriptional, post-translational modification mechanisms and DNA variation. Besides its canonical function in telomere maintenance, hTERT exerts non-canonical roles that contribute to disease progression through telomerase-independent mechanisms. This comprehensive review summarizes the regulatory mechanisms governing hTERT in breast cancer and elucidates the functional implications of its activation. Given the overexpression of hTERT in most breast cancer cells, the detection of hTERT and its associated molecules are potential for enhancing early screening and prognostic evaluation of breast cancer. Although still in its early stages, therapeutic approaches targeting hTERT and its regulatory molecules show promise as viable strategies for breast cancer treatment. These methods are also discussed in this paper.

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“…Zhang ve ark. (2020) RIN1'in (Ras and Rab interactor 1) aşırı eksprese olduğu zaman, telomeraz aktivitesini ve hTERT ekspresyonunu bloke ettiğini göstermişlerdir (23). Mathiyazhagan ve Muthukaliannan (2020) MCF7 hücre hatlarına Zingiber officinale (ZO) ve Terminalia chebula (TC) maddelerini uygulayarak, hücre proliferasyonunda rol oynayan mTOR ve hTERT genlerinin ekspresyon seviyesini aşağı yönde etkilediklerini bildirmişlerdir (24).…”

Section: Sağlıklı Ve Kanserli öRneklerdeki Htert Geni Ekspresyonun Dağılımıunclassified

Meme Kanseri Hastalarında hTERT Gen Ekspresyonunun Klinikopatolojik Önemi

Dirican

Kankaya

Tatar

2022

Sağlık Bilimlerinde Değer

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Bu çalışma, meme kanserinde insan telomeraz ters transkriptaz (hTERT) genin mRNA ekspresyonunun klinik önemini incelemeyi ve klinikopatolojik rolünü araştırmayı amaçlamıştır. hTERT geni hücre proliferasyonu, apoptoz ve hücre invazyonu gibi olaylarda rol almaktadır. Yüksek hTERT mRNA ekspresyonunun meme kanseri, mide, akciğer, glioblastoma, baş ve boyun gibi solid tümörlerde kötü prognoz ile ilişkili olduğu bildirilmektedir. Gereç ve Yöntemler: 59 meme kanser ve sağlıklı kan örneklerinin RNA izolasyonları gerçekleştirildi. hTERT geni mRNA ekspresyonu Gerçek Zamanlı Polimeraz Zincir Reaksiyonu (RT-PZR) yöntemi ile analiz edildi. mRNA ekspresyon sonuçları 2 -∆∆ct metoduyla kanserli ve sağlıklı örneklerde değerlendirildi. Klinik veriler toplandı ve bu verilerin hTERT gen ekspresyonu ile ilişkisi istatiksel olarak değerlendirildi. Bulgular: Meme kanser hastalarında hTERT geni mRNA ekspresyonu sağlıklı örneklere kıyasla anlamlı derecede yüksekti (p=0,0211). Düşük hTERT geni ekspresyonu östrojen reseptör (ÖR) (+) ve insan epidermal büyüme faktör reseptörü 2 (HER 2) (+) olan hastalarda anlamlı derecede ilişkiliydi (sırasıyla p=0,0464; p=0,0080). hTERT geni ekspresyonu histolojik derece (grade) 3 hastalarda derece 2'ye kıyasla yüksek anlamlı bulundu (p=0,0389). Bununla birlikte hTERT ekspresyonun bazal benzeri histolojik tipte luminal A ve luminal B'ye kıyasla anlamlı derecede yüksek olduğu gösterildi (sırasıyla p=0,0160; p=0,0008). Sonuç: Çalışmamızın bulguları, meme kanser hastalarında hTERT gen ekspresyonunun sağlıklı örneklere göre anlamlı olarak daha yüksek olduğunu gösterdi. Anormal hTERT gen ekspresyonu kanserojenez veya teşhiste önemli bir rol oynayabilir.

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Role of RIN1 on telomerase activity driven by EGF-Ras mediated signaling in breast cancer

Cited by 4 publications

References 44 publications

Expression of RAS and RAB interactor 1 (RIN1) in head and neck tumors at selected hospital in Ghana

Expression of RAS and RAB interactor 1 (RIN1) in head and neck tumors at selected hospital in Ghana

Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer

Meme Kanseri Hastalarında hTERT Gen Ekspresyonunun Klinikopatolojik Önemi

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