Role of Ribavirin in Membranoproliferative Glomerulonephritis Associated with Hepatitis C Virus Infection Refractory to Alpha-Interferon

Pérez-Calvo, Juan Ignacio; Moros, Manuel; Íñigo, Pablo

doi:10.1159/000063289

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…Recently, hepatitis C virus infection has been increasingly implicated as a cause of type I MPGN, [19][20][21][22] and the association of type I MPGN with human immunodeficiency virus (HIV) or other viruses, such as Epstein-Barr virus, BK type polyoma virus, hepatitis G virus, or parvovirus B 19, have also been described in patients after renal transplantation. [23][24][25][26][27] Although serological tests for hepatitis C virus (HCV) antibody were negative in both cases, we did not test for HCV RNA and other viruses.…”

Section: Discussionmentioning

confidence: 99%

Steroid resistance in prolonged type I membranoproliferative glomerulonephritis and accelerated disease remission after steroid withdrawal

et al. 2005

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Two cases of severe proteinuria and hypocomplementemia were referred to our out patient clinic for continuous follow-up. Initial onset of clinical symptoms was at the age of 15 years in both cases. They had already been diagnosed as type I membranoproliferative glomerulonephritis (type I MPGN) by renal biopsy when oral prednisolone administration had been initiated. Several courses of steroid pulse therapy were performed for the flares of the disease, resulting in only temporary amelioration of renal symptoms. Percutaneous renal biopsy was performed during admission on both cases, showing severe glomerular and tubulointerstitial damages, in addition to typical type I MPGN findings such as mesangial cells and matrix interposition and subendothelial deposits. Because the continuous administration of steroid for more than 10 years did not ameliorate the clinical symptoms, steroid was markedly reduced or stopped in these cases. Such withdrawal from steroid therapy accelerated the amelioration of renal symptoms, including decrease in proteinuria, elevation of plasma protein and complement levels, and disappearance of generalized edema. The clinical courses of these cases indicate clinical choice of withdrawal from steroid therapy as one of the treatments in prolonged type I MPGN, which presents in childhood and shows steroid resistance.

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Section: Discussionmentioning

confidence: 99%

Steroid resistance in prolonged type I membranoproliferative glomerulonephritis and accelerated disease remission after steroid withdrawal

et al. 2005

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“…These findings were similar in several other small studies that also examined the effect of interferon-α in MPGN, but sample size was small and no trial had a control group. Isolated cases have also been reported of MPGN in association with HCV, where the MPGN was effectively treated only with the combination of interferon with ribavirin [27], but there have been no larger series or controlled studies. The aggregate of the data on interferon-based treatment for HCV-associated MPGN still lacks long-term outcomes on the benefits to renal function.…”

Section: Renal Associationsmentioning

confidence: 99%