Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis

Asner, Sandra; Waters, Valerie; Solomon, Melinda; Yau, Yvonne; Richardson, Susan E.; Grasemann, Hartmut; Gharabaghi, Farhad; Tran, Dat

doi:10.1016/j.jcf.2012.04.006

Cited by 84 publications

(103 citation statements)

References 24 publications

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“…269,270 Exacerbations in which a virus is identified are associated with worse clinical severity compared with viral exacerbations. 274 As sensitive viral detection methods like real-time PCR become increasingly available and identify a broader range of viruses, 275 the role played by other viral pathogens (eg, coronavirus and human metapneumovirus) in CF exacerbations will be further elucidated.…”

Section: Iiib3 Respiratory Virusesmentioning

confidence: 99%

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

339

378

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The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline for CF. During the past decade, new knowledge and new challenges provided the following rationale to develop updated IP&C strategies for this unique population:1. The need to integrate relevant recommendations from evidence-based guidelines published since 2003 into IP&C practices for CF. These included guidelines from the Centers for Disease Control and Prevention (CDC)/Healthcare Infection Control Practices Advisory Committee (HICPAC), the World Health Organization (WHO), and key professional societies, including the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). During the past decade, new evidence has led to a renewed emphasis on source containment of potential pathogens and the role played by the contaminated healthcare environment in the transmission of infectious agents. Furthermore, an increased understanding of the importance of the application of implementation science, monitoring adherence, and feedback principles has been shown to increase the effectiveness of IP&C guideline recommendations.2. Experience with emerging pathogens in the non-CF population has expanded our understanding of droplet transmission of respiratory pathogens and can inform IP&C strategies for CF. These pathogens include severe acute respiratory syndrome coronavirus and the 2009 influenza A H1N1. Lessons learned about preventing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant gram-negative pathogens in non-CF patient populations also can inform IP&C strategies for CF.

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Section: Iiib3 Respiratory Virusesmentioning

confidence: 99%

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

339

378

View full text Add to dashboard Cite

show abstract

“…Viruses have been identified in up to 60% of CF related pulmonary exacerbations with a higher prevalence in children [2][3][4][5]. FLIGHT et al [4] identified viruses in 40% of exacerbations in adult patients with CF; viral PCR was performed on nasal, throat, and sputum specimens.…”

Section: Pathogenicity Of Individual Rhinovirus Species During Exacermentioning

confidence: 99%

“…Diaphragm pacing is an alternative to mechanical ventilation in patients with high cervical cord damage (>C4 dermatome). It brings clinical benefits and reduces health costs [1][2][3]. It is also indicated in certain cases of central hypoventilation [4].…”

Section: Pathogenicity Of Individual Rhinovirus Species During Exacermentioning

confidence: 99%

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Pathogenicity of individual rhinovirus species during exacerbations of cystic fibrosis

et al. 2015

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“…It is estimated that 31-61% of pulmonary exacerbations in CF patients are triggered by respiratory viruses [1,2]. The most predominant viruses exacerbating CF lung disease are human rhinoviruses (RVs), which are detected in up to 70% of virus-induced CF exacerbations [3,4].…”

Section: Introductionmentioning

confidence: 99%

Novel antiviral properties of azithromycin in cystic fibrosis airway epithelial cells

et al. 2014

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Virus-associated pulmonary exacerbations, often associated with rhinoviruses (RVs), contribute to cystic fibrosis (CF) morbidity. Currently, there are only a few therapeutic options to treat virus-induced CF pulmonary exacerbations. The macrolide antibiotic azithromycin has antiviral properties in human bronchial epithelial cells. We investigated the potential of azithromycin to induce antiviral mechanisms in CF bronchial epithelial cells.Primary bronchial epithelial cells from CF and control children were infected with RV after azithromycin pre-treatment. Viral RNA, interferon (IFN), IFN-stimulated gene and pattern recognition receptor expression were measured by real-time quantitative PCR. Live virus shedding was assessed by assaying the 50% tissue culture infective dose. Pro-inflammatory cytokine and IFN-β production were evaluated by ELISA. Cell death was investigated by flow cytometry.RV replication was increased in CF compared with control cells. Azithromycin reduced RV replication seven-fold in CF cells without inducing cell death. Furthermore, azithromycin increased RV-induced pattern recognition receptor, IFN and IFN-stimulated gene mRNA levels. While stimulating antiviral responses, azithromycin did not prevent virus-induced pro-inflammatory responses.Azithromycin pre-treatment reduces RV replication in CF bronchial epithelial cells, possibly through the amplification of the antiviral response mediated by the IFN pathway. Clinical studies are needed to elucidate the potential of azithromycin in the management and prevention of RV-induced CF pulmonary exacerbations. @ERSpublications Azithromycin reduces rhinovirus load in CF bronchial cells, possibly through the induction of the interferon pathway

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Role of respiratory viruses in pulmonary exacerbations in children with cystic fibrosis

Abstract: Compared to non-viral exacerbations, viral-related exacerbations were associated with worse severity and quality of life scores but similar pulmonary inflammation.

Cited by 84 publications

References 24 publications

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Pathogenicity of individual rhinovirus species during exacerbations of cystic fibrosis

Novel antiviral properties of azithromycin in cystic fibrosis airway epithelial cells

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