Role of Renin–Angiotensin-converting Enzyme Level and ACE Gene Polymorphism in Patients with Nonalcoholic Fatty Liver Disease

Abstract

IntroductionIn this study, we aimed to investigate the histological and clinical effect of angiotensin-converting enzyme (ACE) and ACE gene polymorphism in nonalcoholic fatty liver disease (NAFLD) and their roles in the progression of the disease.Materials and methodsLiver function tests, body mass index, waist circumference, lipid parameters, fasting blood glucose (FBG), hemoglobin A1c (HbA1c), homeostasis model assessment-IR (HOMA-IR), ACE, and ACE gene polymorphism were evaluated in the NAFLD group and control group. The study group was evaluated by dividing the group into four subgroups by ACE gene polymorphism (D/D homozygous, I/I homozygous, D/I heterozygous, I/D heterozygous). Liver biopsies were evaluated according to Brunt Classification.ResultsA total of 31 patients who were diagnosed with NAFLD and 40 healthy individuals were included in the study. The ACE level was found to be 11.69 ± 1.99 in the NAFLD group and 11.52 ± 1.72 in the control group (p = 0.70). There was a negative correlation between ACE levels and HOMA-IR levels (p = 0.008, r= −0.512). Biochemical parameters were not different among ACE gene polimorphism subgroups, except FBG (between D/D, I/D and D/I, I/D; p = 0.02). When the ACE levels were compared in terms of grade and stage, no significant difference was found (for stage and grade p = 0.68). The ACE gene polymorphism subgroups did not differ by histopathologic findings; grade and stage (for grade p = 0.42, for stage p = 0.92).ConclusionIn this study, we could not find a correlation of ACE and ACE gene polymorphism with metabolic risk factors and the disease severity in NAFLD.How to cite this articleTekatas DD, Bahcecioglu IH, Ispiroglu M, Sahin A, Ilhan N, Yalniz M, Demirel U. Role of Renin–Angiotensin-converting Enzyme Level and ACE Gene Polymorphism in Patients with Nonalcoholic Fatty Liver Disease. Euroasian J Hepato-Gastroenterol 2016;6(2):137-142.

The resistance to methoxy polyethylene glycol-epoetin beta in anemic patients of end-stage renal disease

“…[ 19 ] who showed no marked influence of the ACE I/D polymorphism on EP necessity in hemodialysis individuals. On the other hand, our findings contradict two recent studies that included continuous ambulatory peritoneal dialysis people and found that the ACE II/ID genotypes are linked to inadequate EP response [ 20 , 21 ]. These findings' variances are attributed to the ethnic differences between people.…”

Effect of angiotensin converting enzyme gene studies in nonalcoholic fatty liver disease subjects

“…Till now, the complete pathogenesis is not confirmed (Zhang et al, 2019). There are limited studies have been recorded with NAFLD in the global population and showed both significant and non-significant association (Güçlü et al, 2010;Tekatas et al, 2016;Sydorchuk et al, 2018). Our study is also in agreement with the previous studies, which showed a negative association (P>0.05).…”

“…The ACE gene insertion/deletion (I/D) polymorphism denotes the appearance or disappearance of 287bp of Alu sequence present at the intron 16 region (Khan et al, 2014). Limited studies have been documented in the NAFLD with ACE gene I/D polymorphism (Tekatas et al, 2016;Sydorchuk et al, 2018;Güçlü et al, 2010). There are no documented studies have been stated in the Saudi population between I/D polymorphism in the ACE gene.…”