Role of Regulatory T cells in Airway Inflammation in Asthma

Kawayama, Tomotaka; Kinoshita, Takashi; Matsunaga, Kazuko; Naito, Yoshiko; Sasaki, Jun; Tominaga, Yoshikazu; Hoshino, Tomoaki

doi:10.2739/kurumemedj.ms6430001

Cited by 13 publications

(10 citation statements)

References 46 publications

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“…4,5,6,7 La inflamación característica está mediada principalmente por el perfil Th2, en el que IL4, IL5 e IL13 promueven la activación, migración y proliferación de eosinófilos y células cebadas para la síntesis de IgE. 8 Por otra parte, el perfil Th1 (IFN-γ, interferón gamma) activa fagocitos, producción de opsoninas y estimula la respuesta inmune celular. 9 Los componentes liberados por ambos perfiles producen broncoconstricción, inflamación y engrosamiento del músculo liso.…”

Section: Antecedentesunclassified

Flujometría versus espirometría para el diagnóstico de asma en adultos

Herrera-Sánchez

Álvarez-Chávez

Castillo‐Hernandez

et al. 2019

RAM

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Antecedentes: El diagnóstico de asma se confirma con espirometría: VEF1 (volumen espiratorio forzado del primer segundo)/CVF (capacidad vital forzada) < 80 %, con reversibilidad (VEF1 >12 % o 200 mL) tras utilizar salbutamol. El flujómetro es barato y fácil de utilizar, mide el flujo espiratorio forzado, cuya reversibilidad > 20 % sugiere asma.Objetivo: Conocer sensibilidad, especificidad y valores predictivos positivos y negativo del flujómetro.Métodos: Estudio transversal, observacional, comparativo. Se incluyó a individuos > 18 años sin contraindicaciones para espirometría, quienes fueron sometidos a espirometría y flujometría y se les aplicó el Asthma Control Test. Se calculó sensibilidad, especificidad y valores predictivos positivo y negativo de la flujometría. Se realizó curva ROC para conocer el punto de corte de mayor sensibilidad y especificidad.Resultados: De 150 pacientes, 66 % fue del sexo masculino; la mediana de edad fue de 38 años. Conforme los criterios de Global Initiative for Asthma 2018, 58.7 % estaba controlado. La sensibilidad de la flujometría fue de 47 %, la especificidad de 87 %, valor predictivo positivo de 54.8 % y negativo de 84 %. La flujometría mostró mayor especificidad con VEF1 < 59 %. El punto de corte de mayor sensibilidad y especificidad fue una reversibilidad de 8 %, con área bajo la curva de 0.70.Conclusiones: El flujómetro tiene mayor sensibilidad en obstrucciones de vía aérea; es de utilidad cuando no se cuenta con un espirómetro.

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Section: Antecedentesunclassified

Flujometría versus espirometría para el diagnóstico de asma en adultos

Herrera-Sánchez

Álvarez-Chávez

Castillo‐Hernandez

et al. 2019

RAM

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“…At the beginning of the formation of inflammation, the mechanisms do not depend on the type of the damage (allergic, infectious, etc.) and have general signs of action of cytokine complexes [10][11][12][13]. Several proinflammatory (IL1, IL-6, IL-8, TNF-α, www.journals.viamedica.pl GM-CSF) and anti-inflammatory cytokines (IL-4, IL-10, IL-13, TGF-b) are synthesized [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Are Level of IL-13 and IL-4 Predictive for Formation of Chronic Inflammation in Children with Asthma?

Makieieva

Vasylchenko

Tsymbal

2020

Advances in Respiratory Medicine

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Introduction: Asthma diagnosis in young children may represent a clinical challenge. There are no standard prognostic and diagnostic methods. The aim of the study was to evaluate the clinical and prognostic assessment of IL-4 and IL-13 concentrations in children with recurrent wheezing. Material and methods: The study included 96 children with recurrent wheezing. 81 patients were diagnosed as transient wheezing, 15 patients with asthma, and 25 healthy children were selected as controls. The concentrations of IL-4 and IL-13 were analyzed in exhaled breath condensate (EBC) using an enzyme-linked immunosorbent assay (ELISA). Data analysis was performed using Statsoft Statistica Version 8 (Tulsa, OK) and the statistical program MedCalc version 17.2. Results: Both IL-4 and IL-13 concentrations were significantly higher in DDA (21.13 pg/mL, 26.13 pg/mL, respectively) and TW (13.86 pg/mL, 18.3 pg/mL, respectively) groups as compared to healthy controls (3.37 pg/mL, 16.35 pg/mL, respectively; p < 0.001), and the highest rates were observed in children with diagnosed asthma (p < 0.001, DDW vs TW, respectively). IL-4 concentration higher than 18.45 pg/mL (with sensitivity 86.7% and specificity 80%) and IL-13 concentration higher than 20.17 pg/ /mL (with sensitivity 100% and specificity 76.7%) in EBC in children with wheezing recurrence can be considered as a possible predictor of asthma development. Conclusions: The concentration of the anti-inflammatory cytokines IL-4 and IL-13 were significantly increased in children with recurrent wheezing and the highest rates were found in asthma developing children. The concentrations of IL-4 and IL-13 in children with wheezing can be considered as a possible predictor of asthma development.

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“…Epidemiological studies show that colonization of the neonatal respiratory tract with S. pneumoniae , Haemophilus influenzae , or Moraxella catarrhalis significantly increases the risk of asthma in the first 5 years of life [3, 4]. Asthma, characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and remodeling, is one of the most common chronic airway diseases among children worldwide [5, 6]. AHR, which is largely attributed by airway structural changes including airway smooth muscle (ASM) hypertrophy/hyperplasia, has long been considered a cardinal feature of asthma [7, 8].…”

Section: Introductionmentioning

confidence: 99%

Neonatal Streptococcus pneumoniae Pneumonia Induces an Aberrant Airway Smooth Muscle Phenotype and AHR in Mice Model

Peng

Kong

et al. 2019

BioMed Research International

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Our previous study showed that neonatal S. pneumoniae infection aggravated airway inflammation and airway hyperresponsiveness (AHR) in an OVA-induced allergic asthma model. As airway smooth muscle (ASM) plays a pivotal role in AHR development, we aim to investigate the effects of neonatal S. pneumoniae pneumonia on ASM structure and AHR development. Non-lethal neonatal pneumonia was established by intranasally infecting 1-week-old BALB/C mice with the S. pneumoniae strain D39. Five weeks after infection, the lungs were collected to assess the levels of α-SMA and the contractile proteins of ASM. Our results indicate that neonatal S. pneumoniae pneumonia significantly increased adulthood lung α-SMA and SMMHC proteins production and aggravated airway inflammatory cells infiltration and cytokines release. In addition, the neonatal S. pneumoniae pneumonia group had significantly higher Penh values compared to the uninfected controls. These data suggest that neonatal S. pneumoniae pneumonia promoted an aberrant ASM phenotype and AHR development in mice model.

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Role of Regulatory T cells in Airway Inflammation in Asthma

Cited by 13 publications

References 46 publications

Flujometría versus espirometría para el diagnóstico de asma en adultos

Flujometría versus espirometría para el diagnóstico de asma en adultos

Are Level of IL-13 and IL-4 Predictive for Formation of Chronic Inflammation in Children with Asthma?

Neonatal Streptococcus pneumoniae Pneumonia Induces an Aberrant Airway Smooth Muscle Phenotype and AHR in Mice Model

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