Role of reduced flavin in dehalogenation reactions

Sobrado, Pablo

doi:10.1016/j.abb.2020.108696

Archives of Biochemistry and Biophysics

2021

DOI: 10.1016/j.abb.2020.108696

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Role of reduced flavin in dehalogenation reactions

Pablo Sobrado

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Cited by 5 publications

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The Reactivity of α‐Fluoroketones with PLP Dependent Enzymes: Transaminases as Hydrodefluorinases

et al. 2021

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A chemical method for the treatment of harmful halogenated compounds that has recently become of interest is the reductive dehalogenation of carbon-halogen bonds. In the case of a fluorine atom, this process is called hydrodefluorination. While many transition metal-based approaches now exist to reductively defluorinate aromatic fluoroarenes, the cleavage of CÀ F bonds in aliphatic compounds is not so well-developed.Here we propose a biocatalytic approach exploiting a promiscuous activity exhibited by transaminases (TAs). Hence, a series of α-fluoroketones have been defluorinated with excellent conversions using Chromobacterium violaceum and Arthrobacter sp. TAs under mild conditions and in aqueous medium, using a stoichiometric amount of an amine (e. g. 2-propylamine) as reagent and formally releasing its oxidized form (e. g. acetone), with ammonia and hydrogen fluoride as by-products. It is also demonstrated that this process can be performed in a regio-or stereoselective fashion.

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The Reactivity of α‐Fluoroketones with PLP Dependent Enzymes: Transaminases as Hydrodefluorinases

et al. 2021

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Current topics in flavins and flavoproteins (Proceedings of the 20th nternational symposium on flavins and flavoproteins)

Macheroux

2021

Archives of Biochemistry and Biophysics

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Wastewater treatment with nanomaterials for the future: A state-of-the-art review

Zahmatkesh

Hajiaghaei–Keshteli

Bokhari

et al. 2023

Environmental Research

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Role of reduced flavin in dehalogenation reactions

Cited by 5 publications

References 73 publications

The Reactivity of α‐Fluoroketones with PLP Dependent Enzymes: Transaminases as Hydrodefluorinases

The Reactivity of α‐Fluoroketones with PLP Dependent Enzymes: Transaminases as Hydrodefluorinases

Current topics in flavins and flavoproteins (Proceedings of the 20th nternational symposium on flavins and flavoproteins)

Wastewater treatment with nanomaterials for the future: A state-of-the-art review

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