Role of red blood cells “annexin V” and platelets “P-selectin” in patients with thalassemia

Abstract

The mean expression of platelets P-selectin in patients with thalassemia major and thalassemia intermedia was significantly higher than that in controls and patients with thalassemia minor. However, its expression was significantly higher in patients with thalassemia intermedia than in those with thalassemia major. Annexin V also showed a positive correlation with P-selectin, and both markers positively correlated with regularity of blood transfusion.

Stroke propensity in the Th3+/ mouse model of β-thalassemia intermedia

“…2B ). These results are consistent with the report of increased pro-coagulant properties of RBCs and platelets in β-thalassemia patients ( Helley et al, 1996 ; Goldschmidt et al, 2008 ; Mahdi et al, 2019 ).…”

“…Since splenectomized β-thalassemia patients may have reduced clearance of abnormal RBCs, future studies are warranted to test the thrombogenic properties of RBCs in β-thalassemia ( Mannucci, 2010 ). The finding of more platelet-RBC-leukocyte aggregates in Th3/+ mice may be caused in part by increased P-selectin exposure in platelets, as has been reported in β-thalassemia patients ( Massberg et al, 1998 ; Merten and Thiagarajan, 2000 ; Mahdi et al, 2019 ; Yokoyama et al, 2005 ; Polanowska-Grabowska et al, 2010 ).…”

Sonoclot Versus conventional coagulation parameter for assessment of hemostasic abnormalities in children with β- Thalassemia: Egyptian center study

“…[20] In the current study, we found that platelet function via clot retraction was abnormal higher in thrombotic patients compared to all patients studied. This could be attributed to chronic activation of platelets either due to the reduced NO levels, which is a major guardian of endothelial integrity and smooth muscle tone regulator, promoting platelet activation and vasoconstriction [21], or due to the pro-coagulant RBC thalassemic membrane stimulating thrombin, which is a strong platelet agonist, that enhance platelet activation [22].…”

The in vitro red blood cell microvesiculation exerts procoagulant activity of blood cell storage in Southeast Asian ovalocytosis

“…Subjects with SAO were recruited based on the presence of ovalocytosis and theta cells (RBCs with two stomas showing a transverse bar/slit in the middle of the cells) on blood smear examination and an age range of 18–60 years. Previous reports showed that some RBC membrane defects (such as spherocytosis and elliptocytosis) and hematological disorders (e.g., thalassemia and hemoglobinopathies) exert hypercoagulable state [ 27 , 28 ]. Therefore, these anomalies were excluded to prevent the interference of procoagulant activity.…”