Role of Real-Time Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in the Diagnosis and Mediastinal Staging of Lung Cancer

Abstract

A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Real-time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive new diagnostic tool used for diagnosis and mediastinal staging of lung cancer. The aim of this study is to evaluate the role of real-time EBUS-TBNA for diagnosis of lymph nodes in patients with suspected lung cancer who had mediastinal and/or hilar lymph nodes. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Between April 2009 and January 2011, 52 patients with mediastinal and/or hilar lymphadenopathy suspected for lung cancer referred for TBNA were enrolled in the study. R Re es su ul lt ts s: : Of 97 lymph node biopsy specimens, 94 were eligible for diagnosis. Of three patients with malignancy negative lymph node biopsy specimens, two gave their consents and underwent mediastinoscopy. The result of one patient was negative, and the other one was positive for malignancy. The third patient was accepted to have a non malignant disease since the positron emission tomography of lymph node was negative for malignancy and remained stable and non-malignant during the follow-up. The sensitivity and specificity of EBUS-TBNA in the diagnostic evaluation of mediastinal and/or hilar lymph nodes of patients with suspected for lung cancer were 98.9% and 100%, respectively. Twelve N3 lymph nodes were diagnosed as positive for malignancy. Twenty three patients without endobronchial lesions on conventional bronchoscopy were diagnosed as lung cancer by real-time EBUS-TBNA. No complications were recorded during the procedures. C Co on nc cl lu us si io on n: : Real-time EBUS-TBNA is an effective and reliable diagnostic procedure. Moreover, it is a very useful tool for diagnosis of lesions which cannot be reached with the conventional bronchoscope.K Ke ey y W Wo or rd ds s: : Lung neoplasms; lymph nodes; diagnosis Ö ÖZ ZE ET T A Am ma aç ç: : Eş zamanlı endobronşiyal ultrason kılavuzlu transbronşiyal iğne aspirasyonu (EBUS-TBNA) akciğer kanserinin teşhisi ve mediastinal evrelemesi için kullanılıp minimal invaziv olan yeni bir teşhis yöntemidir. Bu çalışmanın amacı akciğer kanseri olarak şüphelenilen ve mediastinal ve/veya hiler lenf nodları olan hastalarda lenf nodlarının teşhisi için eş zamanlı EBUS-TBNA'nın rolünü değerlendirmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Nisan 2010-Ocak 2011 arasında akciğer kanseri şüphesi ve mediastinal ve/veya hiler lenf nodları nedeniyle transbronşial biyopsi önerilen 52 hasta çalışmaya alındı. B Bu ul lg gu ul la ar r: : Doksan yedi lenf nodu biyopsi örneğinden 94'ü teşhis için uygundu. Lenf nodu biyopsi örneği malignite negatif olarak raporlanan üç hastanın ikisine rıza göstermeleri üzerine mediastinoskopi uygulandı. Bunlardan biri malignite pozitifti. Üçüncü hasta lenf nodunun pozitron emisyon tomografisinin malignensi için negatif olmasından dolayı non-malign olarak kabul edildi ve takip boyunca stabil ve non-malign olarak kaldı. Akciğer kanseri için şüphelenilen hastaların mediastinal ve/veya hil...

Endobronchial ultrasound-guided transbronchial needle aspiration in diagnosing intrathoracic tuberculous lymphadenitis.

“…It is well documented that EBUS-TBNA is an important tool in staging lung cancer [9,23]. The complications reported are no more than few case reports.…”