Role of reactive oxygen species in cell signalling pathways

Hancock, John T.; Desikan, Radhika; Neill, Steven J.

doi:10.1042/bst0290345

Cited by 632 publications

(309 citation statements)

References 9 publications

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“…The mechanisms of induction of stress response genes are similar among various organisms examined. Similarities in stress-induced changes in gene expression have been observed for a variety of stressors (3,(6)(7)(8). Some that have been studied in detail include radiation, thermal shock, pathogenic infections, anaerobiosis, trauma, photostress, physical wounding, oxidative stress, water stress, and heavy metals.…”

Section: Gene Responsesmentioning

confidence: 79%

Oxidative stress: molecular perception and transduction of signals triggering antioxidant gene defenses

2005

Braz J Med Biol Res

964

470

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Molecular oxygen (O 2 ) is the premier biological electron acceptor that serves vital roles in fundamental cellular functions. However, with the beneficial properties of O 2 comes the inadvertent formation of reactive oxygen species (ROS) such as superoxide (O 2 •-), hydrogen peroxide, and hydroxyl radical (OH • ). If unabated, ROS pose a serious threat to or cause the death of aerobic cells. To minimize the damaging effects of ROS, aerobic organisms evolved non-enzymatic and enzymatic antioxidant defenses. The latter include catalases, peroxidases, superoxide dismutases, and glutathione S-transferases (GST). Cellular ROS-sensing mechanisms are not well understood, but a number of transcription factors that regulate the expression of antioxidant genes are well characterized in prokaryotes and in yeast. In higher eukaryotes, oxidative stress responses are more complex and modulated by several regulators. In mammalian systems, two classes of transcription factors, nuclear factor κB and activator protein-1, are involved in the oxidative stress response. Antioxidant-specific gene induction, involved in xenobiotic metabolism, is mediated by the "antioxidant responsive element" (ARE) commonly found in the promoter region of such genes. ARE is present in mammalian GST, metallothioneine-I and MnSod genes, but has not been found in plant Gst genes. However, ARE is present in the promoter region of the three maize catalase (Cat) genes. In plants, ROS have been implicated in the damaging effects of various environmental stress conditions. Many plant defense genes are activated in response to these conditions, including the three maize Cat and some of the superoxide dismutase (Sod) genes. Correspondence

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Section: Gene Responsesmentioning

confidence: 79%

Oxidative stress: molecular perception and transduction of signals triggering antioxidant gene defenses

2005

Braz J Med Biol Res

964

470

View full text Add to dashboard Cite

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“…It has been observed that physiological levels of ROS are necessary for normal regulation of cell growth and development (Hancock et al 2001). The MnSOD is an important enzyme involved in protection against ROS.…”

Section: Discussionmentioning

confidence: 99%

Differences in developmental competence and gene expression profiles between buffalo (Bubalus bubalis) preimplantation embryos cultured in three different embryo culture media

et al. 2016

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The objective of this study was to compare effects of in vitro culture systems on embryonic development and expression patterns of developmentally important genes in preimplantation buffalo embryos. After IVM/IVF presumptive zygotes were cultured in one of three systems: undefined TCM-199, mCR2aa medium supplemented with 10 % FBS and defined PVA-myo-inositol-phosphate-EGF medium. No (P [ 0.05) differences at 2-cell, 4-cell and 8-cell to 16-cell stages were observed among the three cultured media used, however, increased (P \ 0.05) blastocyst yield, cell number and hatching rate were found in defined medium compared to undefined media. The expression patterns of genes implicated in embryo metabolism (GLUT-1), anti-apoptosis (BCL-2), imprinting (IGF-2R), DNA methylation (DNMT-3A) and maternal recognition of pregnancy (IFNT) were increased (P \ 0.05) in hatched blastocysts derived from defined medium compared to undefined media. In conclusion, serum-free, defined medium improved developmental competence of in vitro cultured buffalo embryos. Whether these differences in morphological development and gene expression have long-term effects on buffalo calves born after embryo transfer remains unknown. However, it is possible that early adaptations of the preimplantation embryo to its environment persist during fetal and post-natal development.

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“…H 2 O 2 is considered to be an important reactive oxidant species and causes cell death via either apoptosis or necrosis. 24 HEK293 cells remained intact following exposure for 24 and 72 h to OA at concentrations of 20 and 80 μmol L À1 , indicating that OA does not cause DNA damage in kidney cell lines. Similar results were obtained for the MDBK cells (results not shown).…”

Section: Cell Culture Studiesmentioning

confidence: 98%

The Effects ofSyzygium aromaticum-Derived Oleanolic Acid on Kidney Function of Male Sprague–Dawley Rats and on Kidney and Liver Cell Lines

et al. 2012

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Studies indicate that Syzygium spp-derived oleanolic acid (OA) enhances renal function of streptozotocin (STZ)-induced diabetic rats as evidenced by its reversal of the previously reported inability of the kidney to excrete Na þ in these animals. We postulated that OA influences Na þ excretion in the proximal tubule, the site where two-thirds of filtered NaCl is reabsorbed through a process mediated by transport proteins. Therefore, the study investigated the effects of OA on proximal tubular Na þ handling in male Sprague-Dawley rats using renal lithium clearance (C Li ). Renal C Li has been used widely in animal and clinical studies to assess proximal tubular function. Sub-chronic doses of OA were administered to rats twice every third day for 5 weeks. Rats treated with deionized water served as control animals. Cytotoxicity of OA on kidney and liver cell lines was assessed by the MTT and comet assays. OA increased Na þ excretion of conscious male Sprague-Dawley rats from week 3 to week 5. By the end of the 5-week experimental period, OA treatment significantly reduced (p < 0.05) plasma creatinine concentration of STZ-induced diabetic rats with a concomitant elevation in glomerular filtration rate (GFR). Acute OA infusion was also associated with increases in fractional excretion of sodium (FE Na ) and lithium (FE Li ) in anesthetized rats in the absence of significant changes in GFR. The MTT assay studies demonstrated that OA increased the metabolic activity of kidney and liver cell lines. Taken together with previous observations, this study implicates the proximal tubule in OA-evoked increases in urinary Na þ output.

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Role of reactive oxygen species in cell signalling pathways

Cited by 632 publications

References 9 publications

Oxidative stress: molecular perception and transduction of signals triggering antioxidant gene defenses

Oxidative stress: molecular perception and transduction of signals triggering antioxidant gene defenses

Differences in developmental competence and gene expression profiles between buffalo (Bubalus bubalis) preimplantation embryos cultured in three different embryo culture media

The Effects ofSyzygium aromaticum-Derived Oleanolic Acid on Kidney Function of Male Sprague–Dawley Rats and on Kidney and Liver Cell Lines

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