Role of Radiotherapy in the Treatment of Renal Cell Cancer: Updated and Critical Review

Fusco, Vincenzo; Parisi, Salvatore; D’Andrea, Barbara; Troiano, Michele; Clemente, Maria Antonietta; Morelli, Franco; Caivano, Rocchina; Guglielmi, Giuseppe

doi:10.5301/tj.5000640

Cited by 6 publications

(6 citation statements)

References 56 publications

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“…In the treatment of rectal cancer, radiotherapy and chemotherapy are often used in combination, as chemotherapy often induces systemic toxicity (31). As technology advances, modern radiation therapy technology enables a high degree of conformity, including the use of computed tomography images to provide high precision and precise treatment, optimizing treatment planning (32,33); however, the limitation of radiation exposure remains an issue with radiotherapy. Therefore, the present study focused on increasing the sensitivity of cells to chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative and pro‑apoptotic effects of Cyclocarya�paliurus polysaccharide and X‑ray irradiation combination on SW480 colorectal cancer cells

Jin

Jiang

2019

Mol Med Report

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The anti-hyperglycemic effects of Cyclocarya paliurus polysaccharide (CPP) have attracted increasing attention; however, limited research has been conducted on the potential effects of CPP on inhibiting tumor growth. The present study aimed to investigate the functions of CPP in combination with X-ray irradiation on colorectal cancer cells and the underlying mechanisms. SW480 cells were treated with various concentrations of CPP for 24, 48 and 72 h to determine cell viability using a Cell Counting Kit-8 assay. Then, the cells were divided into four groups as follows: Control, CPP (100 µmol/l), 8 Gy and CPP + 8 Gy. The proliferation and apoptosis, and colony formation of cells were detected using flow cytometry and plate clone formation assays, respectively. Reverse transcription-quantitative PCR and western blot analyses were conducted to determine the expression of proliferation and apoptosis-associated, and PI3K/Akt signaling-associated genes. Treatment with 75 µmol/l CPP for 48 h significantly decreased cell viability compared with untreated cells. CPP in combination with 8 Gy X-ray treatment significantly promoted the induction of apoptosis, and suppressed cell proliferation and clone formation compared with the control, CPP and 8 Gy groups. The detection of mRNA and protein expression levels by reverse transcription-PCR and western blotting demonstrated that CPP in combination with 8 Gy not only significantly decreased the expression of proliferation marker protein Ki-67, p53 and Bcl-2, but also upregulated the expression of cleaved caspase-3 and Bax, compared with the control. In addition, CPP and 8 Gy combined significantly attenuated the phosphorylation of PI3K and Akt. The present study demonstrated that the combination of CPP with X-ray irradiation suppressed SW480 cell proliferation and promoted cell apoptosis compared with the control, CPP and 8 Gy groups. The underlying mechanisms may involve inhibition of PI3K/Akt signaling.

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Section: Discussionmentioning

confidence: 99%

Antiproliferative and pro‑apoptotic effects of Cyclocarya�paliurus polysaccharide and X‑ray irradiation combination on SW480 colorectal cancer cells

Jin

Jiang

2019

Mol Med Report

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“…Only 16.7% (n = 26) of patients stayed on pazopanib for the duration of the study. The investigator-assessed PFS in the Phase III COM-PAZ trial (10.5 months) and the global prospective observational PRINCIPLE study (10.3 months) were both 10.8 months (Fusco et al, 2017;Grünwald, 2016;.…”

Section: Pazopanibmentioning

confidence: 99%

Comparison of small molecules VEGFR inhibitors in the treatment of renal cell carcinoma

Priefer

2023

Pharmaciana

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Vascular endothelial growth factors receptors (VEGFR) inhibitors play a vital role in the treatment of renal cell carcinoma. These are small molecules that predominantly exhibit anti-angiogenesis activity in conjunction with other anti-tumor effects. These drug therapies are approved for the use in patients as frontline agents or adjuvant therapy in renal cell carcinoma. However, VEGFR inhibitors are associated with undesirable adverse events, with some having a more manageable toxicity profile compared to others. As a result, choice of treatment poses a challenge for healthcare providers and patients. Nonetheless, these agents demonstrate improved disease/progression free survival (DFS/PFS) values and remain a critical component in the treatment of kidney cancer.

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“…However, a study from Rotterdam found that preoperative radiotherapy had no overall survival advantage over surgery. 24,25 Outcomes of radiotherapy after radical nephrectomy were evaluated in both prospective and retrospective studies. The latest stereotactic body radiotherapy (SBRT) technique uses multi-angle projection and focused beam technologies, which allow the targeting of specific tissues with a high dose of radiation without causing damage to normal tissues, meaning it can be applied to metastatic tumors that are relatively insensitive to radiotherapy.…”

Section: Treatmentmentioning

confidence: 99%

Research progress on advanced renal cell carcinoma

Song

Tian²,

et al. 2020

J Int Med Res

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Renal cell carcinoma (RCC) is a malignant tumor and the third most common urinary disease. It was estimated that RCC affected over 350,000 individuals in 2013, and there are nearly 140,000 deaths annually due to this disease. The initial masses in RCC patients are mostly confined to a single organ. However, due to the metastatic spread of cancer cells through the circulatory system, more than 30% of RCC patients relapse after surgery. The appearance of distant metastases often means that patients enter the advanced stage of cancer with low quality of life and a short expected survival time. This review aims to describe the extant research on advanced RCC, including its pathophysiology, heterogeneity, diagnosis, treatment, and prospects. We try to highlight the most suitable means of treating advanced RCC patients, focusing on comprehensive personalized treatments.

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Role of Radiotherapy in the Treatment of Renal Cell Cancer: Updated and Critical Review

Abstract: In the coming years, new studies will be published to confirm and increase the indications for use of RT.

Cited by 6 publications

References 56 publications

Antiproliferative and pro‑apoptotic effects of Cyclocarya�paliurus polysaccharide and X‑ray irradiation combination on SW480 colorectal cancer cells

Antiproliferative and pro‑apoptotic effects of Cyclocarya�paliurus polysaccharide and X‑ray irradiation combination on SW480 colorectal cancer cells

Comparison of small molecules VEGFR inhibitors in the treatment of renal cell carcinoma

Research progress on advanced renal cell carcinoma

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