Role of quantitative intravoxel incoherent motion parameters in the preoperative diagnosis of nodal metastasis in patients with rectal carcinoma

Abstract

An IVIM sequence may be helpful in diagnosing metastatic lymph nodes of rectal carcinoma. Average D and ADC values are more sensitive than f and D* values in this differentiation. J. MAGN. RESON. IMAGING 2016;44:1031-1039.

Higher‐order diffusion MRI characterization of mesorectal lymph nodes in rectal cancer

“…The diffusion parameters obtained in this analysis for the ADC, IVIM, and Kurtosis models, i.e. higher ADC and D and lower D* and k in malignant nodes, are consistent with 2 recent studies employing IVIM and Kurtosis, respectively, to image lymph nodes in patients with rectal cancer, however, in contradiction to the IVIM results from Ref. 29, in which the diffusivity in the malignant nodes is lower.…”

“…To separate the effects of tissue perfusion and diffusion, the intravoxel incoherent motion (IVIM) captures the fast signal decay at low b ‐values due to flow effects, and in many cases it provided better tumor characterization compared to ADC . For rectal cancer, IVIM also improved lymph node differentiation, although the results are not consistent between the 2 studies. Combining IVIM and kurtosis can provide insight into both perfusion and non‐Gaussian diffusion effects and has shown potential for differentiating various tumors as well as lymph nodes in the head and neck region; however, to our knowledge it has not been employed thus far to image lymph nodes involved in rectal cancer.…”

Diffusion kurtosis imaging in identifying the malignancy of lymph nodes during the primary staging of rectal cancer

“…D app and ADC values of metastatic LNs were significantly greater than those of benign LNs. An earlier study from another group also demonstrated that the D and ADC values from intravoxel incoherent motion were significantly higher in metastatic LNs [18]. The greater D value of metastatic nodes in the earlier study might be accounted for by low cellular density, and the heterogeneity of metastatic nodes may be partly caused by the presence of necrotic tissue in the nodes [19].…”

A preliminary exploration of the intravoxel incoherent motion applied in the preoperative evaluation of mediastinal lymph node metastasis of lung cancer

“…As one of the latest MRI technologies, IVIM is more and more widely applied in the study of various human organs. In recent years, some studies have used IVIM to identify benign and malignant tumours (14,15), and the peritoneal lymph node metastasis of rectal cancer (16,17). However, the application of IVIM in the diagnosis of mediastinal lymph node metastasis of lung cancer has not been reported.…”