Role of Protein Z and Protein C in Neonates with Respiratory Distress Syndrome in Egypt (Experience of One Centre)

Abstract

The aim of this study is to evaluate Protein Z (PTZ) and protein C (PTC) levels in newborns suffering from RDS, healthy preterm and full term newborns and to compare PTZ serum levels in RDS preterm infants with healthy preterm before and after recovery. Sixty newborn infants, recruited from the neonatal unit, were enrolled in the study and divided into 3 groups: Group (I): 20 preterm with RDS, Group (II): 20 healthy preterm control newborns (CPT) and Group (III): 20 healthy full term control newborns (CFT). Protein Z and C were measured using ELISA kits. The results of the study showed lower levels of protein Z were obtained in RDS group compared to preterm controls whose levels were significantly lower than in full-term controls. A significant increase in PTZ levels in RDS' group after recovery, when compared to preterm controls. In RDS, no significant correlations existed between PTZ levels (before and after recovery) and routine investigations except for a significant negative correlation with platelets count. No significant differences were found in PTC levels between the 3 studied groups. To conclude: premature newborns suffering from RDS showed decreased serum protein Z levels than normal preterm control newborns with further increase in its pattern after recovery. Further studies are recommended to evaluate the role of PTZ on outcome in premature newborns with RDS and to evaluate the relationship between protein PTZ and PTC and other coagulation factors incriminated in the development of RDS.

Study of Plasma Protein Z level in Neonates with Respiratory Distress Syndrome Compared with Healthy Neonates

“…This was in agreement with other researchers (16) who showed no effect of weight, APGAR score, hemoglobin %, TLCs on PTZ levels. Also, our results were in agreement with other researchers (21) , who noted no effect of weight on PTZ levels.…”

“…They suggested that the reduction of PZ in RDS may contribute to the prothrombotic condition. Our results also were in agreement with the results of a study done by other researchers(16) who found lower levels of protein Z (PZ) in newborns suffering from RDS than in healthy newborns.…”