“…Most intracellular antiapoptotic factors are under transcriptional control of NF-B, which therefore plays a major role in prevention of cell death (30). NF-B activation is induced by whole neisseriae and neisserial porins in various cell systems (5,13,21,23,27,35,59,77); in particular, PorB induces NF-B activation in a manner dependent on TLR2 (46,48,52), a receptor that is not present in HeLa cells (78). To determine whether PorB could induce TLR2-independent NF-B activation in these cells, multiple approaches were used.…”