Role of prostaglandins in acute phase proteins in inflammation

Anbalagan, Karthik; Sadique, J.

doi:10.1016/0006-2944(84)90028-0

Cited by 24 publications

(18 citation statements)

References 16 publications

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“…The effectiveness of W. somnifera in a variety of rheumatologic conditions may be, in part, due to its antiinflammatory (Anbalagan & Sadique, 1981, 1984Begum & Sadique, 1988) and antioxidant properties (Bhattacharya et al, 1997;Dhuley, 1998;Mishra et al, 2000;Prithviraj et al, 2013;Singh et al, 2010) which are likely to contribute to the chemoprevention action (Prakash et al, 2002). Rasool et al (2000) and Rasool and Varalakshmi (2006), by using the adjuvant induced arthritic rat model, have also demonstrated the immunomodulatory role and antiinflammatory activity of W. somnifera roots.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of anti-inflammatory effect ofWithania somniferaroot on collagen-induced arthritis in rats

Gupta

Singh

2013

Pharmaceutical Biology

101

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Context: Withania somnifera (Linn.) Dunal (Solanaceae) has long been used as an herb in Ayurvedic and indigenous medicine and has received intense attention in recent years for its chemopreventive properties. Objective: The present study focuses on the effect of W. somnifera root powder on the behavioral and radiological changes in collagen-induced arthritic rats. Materials and methods: The rats were randomly divided into five groups: normal control, arthritic control, arthritic rats treated with W. somnifera root powder (at dose levels 600 and 800 mg kg À1) and arthritic rats treated with methotrexate (at dose level 0.3 mg kg À1). The treatment with W. somnifera (daily) and methotrexate (weekly) was initiated from the 20th day post collagen immunization and continued up until the 45th day. Arthritis was assessed macroscopically by measuring paw thickness, ankle size and body weight. Arthritic pain was assessed by toe-spread and total print length of the affected paw. Functional recovery due to the oral treatment of W. somnifera and methotrexate was assessed by sciatic functional index and rota rod activity. Results: Administration of W. somnifera root powder (600 mg kg À1) to the arthritic rats significantly decreased the severity of arthritis by effectively suppressing the symptoms of arthritis and improving the functional recovery of motor activity and radiological score. Discussion and conclusion: W. somnifera root has a protective effect against collagen-induced arthritis (CIA) in rats. The results suggest that W. somnifera root powder acts as an antiinflammatory and antioxidant agent in decreasing the arthritic effects in collagen-induced arthritic rats.

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Section: Discussionmentioning

confidence: 99%

Evaluation of anti-inflammatory effect ofWithania somniferaroot on collagen-induced arthritis in rats

Gupta

Singh

2013

Pharmaceutical Biology

101

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“…PGE 2 has previously been shown to mimic the action of IL-6 as an inhibitor of the glucagon-elicited induction of the key gluconeogenetic enzyme phosphoenolpyruvate carboxykinase via the G i -linked EP3-R. 45 This inhibition of the glucagoninduced transcription of the phosphoenolpyruvate carboxykinase gene may represent the hepatocyte' s strategy to economize its resources for the acute phase response. 46 PGE 2 has also been shown to increase the ␣ 2 -MG formation in unstimulated hepatocytes 21 via an as yet unidentified receptor. These actions of PGE 2 indicate that it may be considered an enhancer of the acute phase reaction.…”

Section: G S -Coupled Prostanoid Receptors In Hepatocytesmentioning

confidence: 99%

Induction by interleukin 6 of Gs-coupled prostaglandin E2 receptors in rat hepatocytes mediating a prostaglandin E2–dependent inhibition of the hepatocyte's acute phase response

2000

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“…Anti inflammatory properties of WS root powder have been widely investigated in animal models (5)(6)(7)(11)(12)(13)(14), however its role in SLE still needs attention. The data observed in the present study revealed antiinflammatory activity of the WS root powder in the mice model of this complex autoimmune disorder.…”

Section: Discussionmentioning

confidence: 99%

“…Pertaining to side effects of these drugs, herbal product(s) having the same properties would be beneficial to patients. Anti-inflammatory properties of WS root powder have been investigated in animal models of arthritis (11)(12)(13)(14) in order to authenticate its use as a treatment drug. In a clinical study, WS in herbal formulation proved to be effective against rheumatoid arthritis, proposing its role in this autoimmune disorder (15).…”

Section: Introductionmentioning

confidence: 99%

Prophylactic effect of <i>Withania somnifera</i> on inflammation in a non-autoimmune prone murine model of lupus

Minhas

Minz

Bhatnagar

2011

DD&T

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The immunosuppressive properties of an aqueous suspension of Withania somnifera (WS) root powder were investigated in a pristane induced female Balb/c model of a systemic lupus erythematosus (SLE) like disease. The course of disease is initiated by peritoneal inflammation caused by pristane which results in development of SLE like symptoms, i.e. autoantibody production, proteinuria, and nephritis within a period of five to six months. The model of SLE was established by injecting 0.5 mL of pristane intraperitoneally into female Balb/c mice (12-18 weeks old). WS root powder (500 mg and 1,000 mg per kg body weight) was administered orally from one month prior to disease induction and for the following 6 months. Parameters of inflammation like nitric oxide (NO), Interleukin 6 and tumour necrosis factor-α and reactive oxygen species (ROS) in serum and/or ascitic fluid were measured. Prophylactic administration of WS root powder (500 mg and 1,000 mg per kg body weight) potently inhibits the proinflammatory cytokines, NO, and ROS in the ascitic fluid as well as in serum. Therefore, our results indicate a preventive effect of WS root powder on the mouse model of lupus.

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Role of prostaglandins in acute phase proteins in inflammation

Cited by 24 publications

References 16 publications

Evaluation of anti-inflammatory effect ofWithania somniferaroot on collagen-induced arthritis in rats

Evaluation of anti-inflammatory effect ofWithania somniferaroot on collagen-induced arthritis in rats

Induction by interleukin 6 of Gs-coupled prostaglandin E2 receptors in rat hepatocytes mediating a prostaglandin E2–dependent inhibition of the hepatocyte's acute phase response

Prophylactic effect of <i>Withania somnifera</i> on inflammation in a non-autoimmune prone murine model of lupus

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