Role of Propranolol in the Management of Periocular Hemangiomas

Propranolol induces apoptosis of human umbilical vein endothelial cells through downregulation of CD147

“…20 Propranolol can also induce apoptosis in human gastric adenocarcinoma cell lines and hepatocytes. 17,18 In the current study, we found that propranolol can downregulate CD147 expression in a concentration-dependent manner in HUVECs. We speculate that the use of propranolol to treat IHs might function by inhibiting cell proliferation and ⁄or by inducing cell apoptosis.…”

“…6 Propranolol was also reported to reduce angiogenesis through inhibition of cell proliferation, migration and differentiation in human umbilical vein endothelial cells (HUVECs). 17,18 Furthermore, studies have demonstrated that propranolol can induce apoptosis of different cell types, including capillary endothelial cells 19 and pancreatic carcinoma cells. Previous studies reported that CD147 was enriched on the surface of various malignant tumour cells, such as malignant melanoma cells 8 and human oral squamous carcinoma cells.…”

Systemic Beta-Blockers May Reduce the Need for Repeated Intravitreal Injections in Patients With Wet Age-Related Macular Degeneration Treated by Bevacizumab

“…20 Systemic BABA are frequently used in the clinical practice to treat cardiac arrhythmia, hypertension, migraine, and hyperthyroidism among other conditions. Propanolol has been used to treat neovascular conditions such as infantile capillary hemangiomas [21][22][23][24][25][26][27][28][29][30][31] and retinopathy of prematurity 32 ; clinical trials are underway to elucidate the effect of these therapies.…”

The use of propranolol in the management of periocular capillary haemangioma—a systematic review

“…26 It is used at a lower dose for treatment of periocular IHs. A 40-year review of propranolol toxicity in children found no cases of mortality, 28 and in all cases, adverse effects resolved either spontaneously or when the drug was stopped. 37 The known side effects of propranolol include bronchospasm, 14 hypoglycaemia, 16,21,38 mood disturbances, somnolence, 39 bradycardia, and hypotension.…”