Role of prophylactic antibiotics in endoscopic gynaecological surgery; a consensus proposal

Minas, Vasileios; Gul, Nahid; Rowlands, David J.

doi:10.1007/s10397-014-0841-9

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…The present study will use a randomized, double-blind design to assess SSI rates, and includes a placebo group. Minas et al in another recent review of literature concluded that there is a paucity of evidence to address the use of antibiotic prophylaxis in gynecologic hysteroscopy, laparoscopy and robotic surgery [28]. Morrill et al concluded that antibiotic prophylaxis for laparoscopic surgery does not provide a significant benefit and questioned the applicability of studies that were published some time ago [9].…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Prophylaxis in Gynecologic Laparoscopy: Study Protocol for a Randomized Controlled Trial

Campos¹

2014

J Clin Trials

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Background: Laparoscopy is a surgical procedure indicated for most gynecological pathologies. It presents numerous advantages over laparotomy; among these are lower rates of surgical site infection and less febrile comorbidity. Despite this, the use of antibiotic prophylaxis is widely accepted and performed by most gynecologists. However, no evidence exists in the literature to support the routine use of antibiotics in the prophylaxis of wound infection in laparoscopic pelvic surgery.Objective: This study aims to assess the surgical site infection rates for gynecological laparoscopies, not involving the opening of hollow viscera, among patients receiving or not antibiotic prophylaxis.Methods: This is a clinical, prospective, double-blind, randomized study. A total of 216 women with gynecological pathologies, undergoing laparoscopic surgical approach, will be consecutively selected. The patients will be randomly allocated to either the placebo group (n=108), to receive 10 mL of intravenous sterile saline, or to the antibiotic group (n=108), to receive 1 g of intravenous cefazolin 30 minutes before the surgery. To evaluate the incidence of surgical site infection, criteria of the Centers for Disease Control and Prevention (CDC) will be used. The patients will be evaluated weekly for 30 days. Discussion:The CDC "Guideline for Prevention of Surgical Site Infection" provides recommendations for the prevention of surgical site infections. However, for some practices, no recommendations are offered, due to a lack of consensus or insufficient evidence on the effectiveness of preventative measures. Interventions to reduce the incidence of surgical site infections are essential to reduce not only morbidity, but also costs to patients and society.

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Section: Discussionmentioning

confidence: 99%