Role of Prolactin in the Regulation of Bicarbonates Biodynamics in Female Rat Model of Cholestasis of Pregnancy

Abstract

We studied possible involvement of prolactin in the regulation of bicarbonate biodynamics using female rat model of cholestasis of pregnancy induced by transplantation of the donor pituitary under the renal capsule of a recipient (hyperprolactinemia) and bile duct ligation (cholestasis). The concentration of bicarbonates in the bile and blood, their excretion, clearance, and reabsorption, as well as glomerular filtration rate and excretion of sodium ions were assessed. It was found that the main effect of prolactin was directed to the kidney-regulated pool of bicarbonates and consisted in stimulation of their clearance and inhibition of reabsorption, which led to a decrease in bicarbonate blood concentration. Parallel influence of prolactin on the clearance of bicarbonates and sodium ions was observed.

Molecular Pathogenesis of Intrahepatic Cholestasis of Pregnancy

“…Last, Bulaeva et al showed that in ICP rat models, the main effect of prolactin was stimulation of bicarbonate clearance and inhibition of reabsorption, which led to a decrease in bicarbonate blood concentration [ 41 ]. How this effect of prolactin contributes to the pathogenesis of ICP still needs more clinical research studies.…”