Role of probiotics in the management of cervical cancer: An update

Kusuma, Kandati; Belagal, Praveen; Nannepaga, John Sushma; Viswanath, Buddolla

doi:10.1016/j.clnesp.2022.02.017

Cited by 11 publications

(7 citation statements)

References 91 publications

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“…Probiotics mainly enhance the immune process of the body, promote the production of cytokines, and inhibit the proliferation of monocytes. Recent studies have shown that probiotics such as Lactobacillus casei and Lactobacillus rhamnosus play an anticancer role by activating the maturation of NK cells and dendritic cells ( Li et al., 2020 ; Kandati et al., 2022 ). Lactobacillus can also affect cellular and humoral immunity, promote the proliferation and differentiation of thymus derived cells, and further promote the immune recognition and proliferation of bone marrow-derived cells ( Medina-Contreras et al., 2020 ).…”

Section: Probiotics and Cervical Cancermentioning

confidence: 99%

The role of probiotics in vaginal health

Mei¹,

2022

Front. Cell. Infect. Microbiol.

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Probiotics have been widely used in the treatment of intestinal diseases, but the effect of probiotics on female reproductive tract health is still controversial. Lactobacillus is the most abundant microorganism in the vagina, which is related to the vaginal mucosal barrier. Lactobacillus adheres to the vaginal epithelium and can competitively antagonize the colonization of pathogens. The factors produced by Lactobacillus, such as bacteriocin and hydrogen peroxide (H2O2), can inhibit the growth of pathogenic microorganisms and maintain the low pH environment of the vagina. Probiotics play an important role in maintaining the stability of vaginal microenvironment, improving immune defense and blocking the progression of cervical cancer. We review the research progress of probiotics represented by Lactobacillus in gynecological diseases such as human papilloma virus (HPV) infection, bacterial vaginosis (BV) and Genitourinary Syndrome of Menopause (GSM), so as to provide basis for further exerting the role of probiotics in women’s health.

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Section: Probiotics and Cervical Cancermentioning

confidence: 99%

The role of probiotics in vaginal health

Mei¹,

2022

Front. Cell. Infect. Microbiol.

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“…10 The noisy sequences of raw tags were filtered through the QIIME (v1.9.1) pipeline using specific filtering conditions to obtain high-quality clean tags. 11 The labels were then clustered into operational taxonomic units (OTUs) using the USEARCH (v 7.0.1090) software script, with a similarity threshold of 97%. 12 Taxonomic classification of representative OTU sequences was performed using the Ribosome Database Project classifier v.2.2, which was trained on the Greengenes database.…”

Section: Sequencing Data Analysismentioning

confidence: 99%

Different effects of CO₂ laser and estrogen treatment on vaginal mucosa microbiota and function in genitourinary syndrome of menopause patients

Qi,

Mo,

Wang

et al. 2024

J of Obstet and Gynaecol

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AimTo characterize the effects of CO2 laser treatment and estrogen treatment on vaginal microbiota in patients with genitourinary syndrome of menopause (GSM).MethodsSixty‐four patients with genitourinary syndrome were divided into the estrogen group, the CO2 laser group, and the control group. The control group did not receive any treatment. Vaginal mucosa was collected after 3 and 12 months of treatment. The former was used for 16S rRNA sequencing, and the latter was used for pathological evaluation. Vaginal health and voiding function were assessed using the vaginal health index (VHI) scale and the UDI‐6 scale at 3 and 12 months after treatment.ResultsThe results showed that both treatments reduced alpha diversity in the vaginal flora. Additionally, the abundance of 65 genera differed significantly between the treatment and control groups, with an increase in potentially beneficial bacteria such as Lactobacillus, IheB3_7, Mycoplasma urealyticum, and Streptococcus. In addition, the VHI and UDI‐6 scores improved in both treatment groups compared to the control group after 3 months. Whereas VHI and UDI‐6 scores were close to baseline in the estrogen group, and remained significantly improved in the CO2 laser group after 12 months. Pathological results showed that both methods improved the vaginal health status of patients with GSM after 12 months of treatment. However, the CO2 group exhibited a more significant increase in type III collagen.ConclusionsBoth CO2 laser and estrogen therapies can regulate the vaginal flora imbalance of GSM and improve the corresponding symptoms. However, the long‐term efficacy of CO2 laser therapy is superior compared to estrogen therapy.

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“…Different studies suggest that the main causes of cancer in India are a combination of various factors, including tobacco use (both smoking and smokeless forms), unhealthy diet and lifestyle, exposure to environmental pollution, and infections such as human papillomavirus (HPV) and hepatitis B and C viruses (HBV and HCV). [13][14][15] Therefore, prevention strategies that address these risk factors are crucial in reducing the burden of cancer in India.…”

Section: Factors Contributing Cancer In Indian Populationmentioning

confidence: 99%

“…Modern epidemiological as well as experimental studies have shown a striking association between higher probiotic intake and slowed cancer development, and Lactobacilli have been demonstrated to have the capacity to suppress the growth of numerous types of cervical cancer cells. 15 It's crucial to note that probiotics cannot replace conventional cancer treatments such as chemotherapy, surgery, and radiation. However, they may have potential as adjunctive therapy to improve the efficacy of cancer treatments and reduce side effects.…”

Section: Cervical Cancermentioning

confidence: 99%

Antioncogenic potential of probiotics: Challenges and future prospective

Chattaraj

Mitra²,

Chattaraj³

et al. 2023

IJMR

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Probiotics are beneficial microorganisms that have shown to possess numerous health benefits. Recently, there has been budding interests in the utilization of probiotics as a prospective weapon for cancer deterrence and management. The antioncogenic attributes of probiotics were provided through various mechanisms such as immune modulation, production of anticancer compounds, and regulation of intestinal microbiota. The current study shed light on the antioncogenic probiotic strains and explored their anticancer mechanisms. However, the use of probiotics for cancer prevention and treatment also poses several challenges, including the identification of specific strains with the most potent antioncogenic effects, the optimal dosage and duration of treatment, and the hazards allied with the implementation of live microorganisms. Additionally, the heterogeneity of cancer types and patients' microbiomes further complicate the selection of probiotics for clinical applications. Hence, future study should concentrate on the development of alternative approaches such as the use of microbial-derived components, genetically modified probiotics, and synthetic biology to overcome these challenges and enhance the antioncogenic potential of probiotics.

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Role of probiotics in the management of cervical cancer: An update

Cited by 11 publications

References 91 publications

The role of probiotics in vaginal health

The role of probiotics in vaginal health

Different effects of CO₂ laser and estrogen treatment on vaginal mucosa microbiota and function in genitourinary syndrome of menopause patients

Antioncogenic potential of probiotics: Challenges and future prospective

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Role of probiotics in the management of cervical cancer: An update

Cited by 11 publications

References 91 publications

The role of probiotics in vaginal health

The role of probiotics in vaginal health

Different effects of CO2 laser and estrogen treatment on vaginal mucosa microbiota and function in genitourinary syndrome of menopause patients

Antioncogenic potential of probiotics: Challenges and future prospective

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Product

Resources

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Different effects of CO₂ laser and estrogen treatment on vaginal mucosa microbiota and function in genitourinary syndrome of menopause patients