Role of probiotics in the prevention and treatment of meticillin-resistant Staphylococcus aureus infections

Sikorska, Hanna; Smoragiewicz, Wanda

doi:10.1016/j.ijantimicag.2013.08.003

Cited by 131 publications

(111 citation statements)

References 73 publications

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“…L. acidophilus is already known for its antimicrobial activity against S. aureus and E. coli [28], but the antibiofilm property has been demonstrated only in co-culture with S. aureus [29]. Unlike S. boulardii, the antimicrobial effects of L. acidophilus, L. lactis, L. casei and L. reuteri, mediated by direct cell competitive exclusion, as well as the production of acids or bacteriocin-like inhibitors against S. aureus, are already extensively studied [30]. The capacity of L. acidophilus CFS to inhibit the production of the virulence factor lipase by planktonic and sessile S. aureus has been reported, but no information are available about the biofilm mass.…”

Section: Discussionmentioning

confidence: 99%

Antibiofilm and Antiadhesive Activities of Different Synbiotics

Stefania¹,

Mir²,

Diana³

et al. 2017

J Prob Health

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Synbiotics are a combination of probiotic bacteria and the growth promoting prebiotic ingredients that purport "synergism".Probiotics are well known for their ability to restore a healthful balance of commensal microbes supporting the repair of hyper-permeable epithelial barriers and interfering with infection. The present research was designed to evaluate the anti-virulence role of cell-free supernatants of synbiotic cultures.The effect of prebiotics fructo-oligosaccharide, inulin and isomaltose on probiotic Lactobacillus acidophilus, Lactococcus lactis, Lactobacillus casei, Lactobacillus reuteri and Saccharomyces boulardii growth, fermentation products has been investigated. Cell-free supernatants of synbiotics cultures have been studied for their antimicrobial, antibiofilm and anti-adhesion properties. Results highlight that prebiotics can enhance the antimicrobial and anti-virulence activities of probiotics against potential pathogens Staphylococcus aureus and Escherichia coli.The present research supports, for the first time, the value of anti-virulence activity of metabolites produced by synbiotics suggesting their use as a suitable adjuvant in antibacterial treatment.

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Section: Discussionmentioning

confidence: 99%

Antibiofilm and Antiadhesive Activities of Different Synbiotics

Stefania¹,

Mir²,

Diana³

et al. 2017

J Prob Health

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“…2009; Luerce et al. 2014), antimicrobial (Sikorska and Smoragiewicz 2013; Nami et al. 2014), and antiallergy (Rutten et al.…”

Section: Discussionmentioning

confidence: 99%

Daikenchuto (TU‐100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K

Hasebe

Ueno

Musch

et al. 2016

Pharmacology Res & Perspec

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Many pharmaceutical agents not only require microbial metabolism for increased bioavailability and bioactivity, but also have direct effects on gut microbial assemblage and function. We examined the possibility that these actions are not mutually exclusive and may be mutually reinforcing in ways that enhance long‐term of these agents. Daikenchuto, TU‐100, is a traditional Japanese medicine containing ginseng. Conversion of the ginsenoside Rb1 (Rb1) to bioactive compound K (CK) requires bacterial metabolism. Diet‐incorporated TU‐100 was administered to mice over a period of several weeks. T‐RFLP and 454 pyrosequencing were performed to analyze the time‐dependent effects on fecal microbial membership. Fecal microbial capacity to metabolize Rb1 to CK was measured by adding TU‐100 or ginseng to stool samples to assess the generation of bioactive metabolites. Levels of metabolized TU‐100 components in plasma and in stool samples were measured by LC‐MS/MS. Cecal and stool short‐chain fatty acids were measured by GC‐MS. Dietary administration of TU‐100 for 28 days altered the gut microbiota, increasing several bacteria genera including members of Clostridia and Lactococcus lactis. Progressive capacity of microbiota to convert Rb1 to CK was observed over the 28 days administration of dietary TU‐100. Concomitantly with these changes, increases in all SCFA were observed in cecal contents and in acetate and butyrate content of the stool. Chronic consumption of dietary TU‐100 promotes changes in gut microbiota enhancing metabolic capacity of TU‐100 and increased bioavailability. We believe these findings have broad implications in optimizing the efficacy of natural compounds that depend on microbial bioconversion in general.

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“…These results showed that L. fermentum -secreted compound(s) inhibited both growth and biofilm formation of several S. aureus and P. aeruginosa strains. 127 Finally, L. plantarum has been demonstrated to be topically effective in preventing skin wound infections in mice 128 , not only against P. aeruginosa 124 but also against S. aureus .…”

Section: Competition and Interference Of Probiotics With Wounds Biofilmmentioning

confidence: 99%

Probiotics to counteract biofilm-associated infections: promising and conflicting data

2014

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Altered bowel flora is currently thought to play a role in a variety of disease conditions, and the use of Bifidobacterium spp. and Lactobacillus spp. as probiotics has been demonstrated to be health-promoting, even if the success of their administration depends on the applied bacterial strain(s) and the targeted disease. In the last few decades, specific probiotics have been shown to be effective in the treatment or the prevention of acute viral gastroenteritis, pediatric post-antibiotic-associated diarrhea, some pediatric allergic disorders, necrotizing enterocolitis in preterm infants, inflammatory bowel diseases and postsurgical pouchitis. The potential application of probiotics is continuously widening, with new evidence accumulating to support their effect on the prevention and treatment of other disease conditions, including several oral diseases, such as dental caries, periodontal diseases and oral malodor, as well as genitourinary and wound infections. Considering the increasingly widespread ability of pathogens to generate persistent biofilm-related infections, an even more attractive proposal is to administer probiotics to prevent or counteract biofilm development. The response of biofilm-based oral, intestinal, vaginal and wound infections to probiotics treatment will be reviewed here in light of the most recent results obtained in this field.

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Role of probiotics in the prevention and treatment of meticillin-resistant Staphylococcus aureus infections

Cited by 131 publications

References 73 publications

Antibiofilm and Antiadhesive Activities of Different Synbiotics

Antibiofilm and Antiadhesive Activities of Different Synbiotics

Daikenchuto (TU‐100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K

Probiotics to counteract biofilm-associated infections: promising and conflicting data

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