Role of Probiotics in Managing of Helicobacter Pylori Infection: A Review

Kafshdooz, Taiebeh; Akbarzadeh, Abolfazl; Seghinsara, Abbas Majdi; Pourhassan, Moghadam; Nasrabadi, Hamid Tayefi; Milani, Morteza

doi:10.1055/s-0042-116441

Cited by 19 publications

(18 citation statements)

References 61 publications

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“…The combined use of antibiotics and probiotics has recently been shown to improve the eradication rate for certain infections (Kafshdooz et al, 2017 ). However, there is yet insufficient data to assess the safe use of probiotic bacteria in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Adaptive Amoxicillin Resistance of Lactobacillus casei Zhang by Proteomic Analysis

et al. 2018

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Amoxicillin is one of the most commonly prescribed antibiotics for bacterial infections and gastrointestinal disorders. To investigate the adaptation of Lactobacillus (L.) casei Zhang to amoxicillin stress, an iTRAQ-based comparative proteomic analysis was performed to compare the protein profiles between the parental L. casei Zhang and its amoxicillin-resistant descendent strains. Our results revealed a significant increase in the relative expression of 38 proteins (>2.0-folds, P < 0.05), while the relative expression of 34 proteins significantly decreased (<−2.0-folds, P < 0.05). The amoxicillin-resistant descendent strain exhibited marked alterations in carbohydrate and amino acid metabolism. Moreover, certain components involving in membrane metabolism were activated. The differences in the proteomic profiles between the two strains might explain the enhanced stress resistance of the adapted bacteria.

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Section: Discussionmentioning

confidence: 99%

Characterization of the Adaptive Amoxicillin Resistance of Lactobacillus casei Zhang by Proteomic Analysis

et al. 2018

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“…The most important characterisics of a microorganism as a probiotic are: the ability to pass through the gastro-intestinal tract, tolerance to low pH and bile salt, auto-aggregation and co-aggregation, hydrophobicity, the presence of the genes encoding adhesion proteins, β-galactosidase production, survival in the presence of commercial drugs, and the absence of the genes encoding virulence factors. Studies indicate that L. Bulgaricus almost has all of the above mentioned characterisics [30][31][32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Lactobacilus Delbrueckii subsp. Bulgaricus Modulates the Secretion of Th1/Th2 and Treg Cell-Related Cytokines by PBMCs from Patients with Atopic Dermatitis

Sheikhi

Giti²,

Heibor

et al. 2017

Drug Res (Stuttg)

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Atopic dermatitis (AD) is an inflammatory skin disease which may be due to the imbalance between Th1-, Th2 and Treg cell-related immune responses. Evidences suggest that appropriate stimulation with probiotics may correct the skewed immune response in children with AD. The aim was to determine the effects of the yogurt culture on the secretion of Th1/Th2/Treg type cytokines by PBMCs from children with AD. was cultivated on MRS broth. The PBMCs from 20 children with AD were separated by Ficoll-Hypaque centrifugation and co-cultured with different concentrations of UV killed bacteria in RPMI-1640 plus 10% FCS for 48/72 h. The levels of IL-10, IL-4, IL-12 and IFN-γ were measured in supernatant of PBMCs by ELISA. significantly up-regulated the secretion of IL-10, IL-12 and IFN-γ, whereas decreased the secretion of IL-4 by PBMCs at both incubation times 48 h/72 h and both bacteria:PBMCs ratios 100:1/50:1, compared to control (p<0.05). There were no significant differences between incubation times 48 h and 72 h regarding the secretion levels of IL-12, IFN-γ and IL-4. However, the secretion of IL-10 by -stimulated PBMCs at incubation time 72 h and in the presence of bacteria:PBMCs ratio 100:1 was significantly higher than in incubation time 48 h and in the presence of bacteria:PBMCs ratio 50:1 (P<0.000 and P<0.00, respectively). These data show that may modulate the secretion of Th1-, Th2-Treg-related cytokines in AD patients. Therefore, the possible potential therapeutic of for treatment of AD should be consider in further investigation.

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“…In theory, prebiotics, probiotics, and symbiotics can reestablish the gut microbiota, competing for nutrients with pathogenic bacteria, inhibiting the activity of toxins, and performing immunomodulatory functions (162) . Experimental animal studies have shown that surface proteins in probiotic strains limit the colonization of the stomach by HP (163) . Strains of Lactobacillus salivarius and L. casei may inhibit HP urease activity (by producing lactic acid) and synthesize cytokines, which are involved in inflammatory processes (164) .…”

Section: Level Of Evidence: 4 Grade Of Recommendation: Cmentioning

confidence: 99%

Ivth Brazilian Consensus Conference on Helicobacter Pylori Infection

Coelho

Marinho

Genta

et al. 2018

Arq. Gastroenterol.

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Significant progress has been obtained since the III Brazilian Consensus Conference on H. pylori infection held in 2012, in Bento Gonçalves, Brazil, and justify a fourth meeting to establish updated guidelines on the current management of H. pylori infection. Therefore, the Núcleo Brasileiro para Estudo do Helicobacter pylori e Microbiota (NBEHPM), association linked to Brazilian Federation of Gastroenterology (FBG) held its fourth meeting again in Bento Gonçalves, RS, Brazil, on August 25-27, 2017. Twenty-six delegates, including gastroenterologists, endoscopists, and pathologists from the five regions of Brazil as well as one international guest from the United States, participated in the meeting. The participants were invited based on their knowledge and contribution to the study of H. pylori infection. The meeting sought to review different aspects of treatment for infection; establish a correlation between infection, dyspepsia, intestinal microbiota changes, and other disorders with a special emphasis on gastric cancer; and reassess the epidemiological and diagnostic aspects of H. pylori infection. Participants were allocated into four groups as follows: 1) Epidemiology and Diagnosis, 2) Dyspepsia, intestinal microbiota and other afections, 3) Gastric Cancer, and, 4) Treatment. Before the consensus meeting, participants received a topic to be discussed and prepared a document containing a recent literature review and statements that should be discussed and eventually modified during the face-to-face meeting. All statements were evaluated in two rounds of voting. Initially, each participant discussed the document and statements with his group for possible modifications and voting. Subsequently, during a second voting in a plenary session in the presence of all participants, the statements were voted upon and eventually modified. The participants could vote using five alternatives: 1) strongly agree; 2) partially agree; 3) undecided; 4) disagree; and 5) strongly disagree. The adopted consensus index was that 80% of the participants responded that they strongly or partially agreed with each statement. The recommendations reported are intended to provide the most current and relevant evidences to management of H. pylori infection in adult population in Brazil.

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Role of Probiotics in Managing of Helicobacter Pylori Infection: A Review

Cited by 19 publications

References 61 publications

Characterization of the Adaptive Amoxicillin Resistance of Lactobacillus casei Zhang by Proteomic Analysis

Characterization of the Adaptive Amoxicillin Resistance of Lactobacillus casei Zhang by Proteomic Analysis

Lactobacilus Delbrueckii subsp. Bulgaricus Modulates the Secretion of Th1/Th2 and Treg Cell-Related Cytokines by PBMCs from Patients with Atopic Dermatitis

Ivth Brazilian Consensus Conference on Helicobacter Pylori Infection

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