Role of Presenilin-1 in Modulating Glycogen Synthase Kinase 3 β Expression in the Pathogenesis of Alzheimer’s Disease

Abstract

Results: The PI3K/Akt signaling pathway will untangle the link between PS-1, β -catenin and GSK3β, acting as a phosphorylation "switch" to regulate the downstream effects of its substrates and to provide a module for neuroprotection in AD. Conclusions: The present review intended to unravel the prospective role of presenilin -1 in modulatingGSK3β and to further exploit this link in implicating newer therapeutic interventions.